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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Effects of High-Fat and High-Fat/High-Sucrose Diet-Induced Obesity on PVAT Modulation of Vascular Function in Male and Female Mice

Texto completo
Autor(es):
Victorio, Jamaira A. [1] ; Guizoni, Daniele M. [1] ; Freitas, Israelle N. [1] ; Araujo, Thiago R. [2] ; Davel, Ana P. [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, Lab Vasc Biol, Campinas - Brazil
[2] Univ Estadual Campinas, Obes & Comorbid Res Ctr OCRC, Inst Biol, Dept Struct & Funct Biol, Campinas - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: FRONTIERS IN PHARMACOLOGY; v. 12, SEP 10 2021.
Citações Web of Science: 1
Resumo

Increased adiposity in perivascular adipose tissue (PVAT) has been related to vascular dysfunction. High-fat (HF) diet-induced obesity models are often used to analyze the translational impact of obesity, but differences in sex and Western diet type complicate comparisons between studies. The role of PVAT was investigated in small mesenteric arteries (SMAs) of male and female mice fed a HF or a HF plus high-sucrose (HF + HS) diet for 3 or 5 months and compared them to age/sex-matched mice fed a chow diet. Vascular responses of SMAs without (PVAT-) or with PVAT (PVAT+) were evaluated. HF and HF + HS diets increased body weight, adiposity, and fasting glucose and insulin levels without affecting blood pressure and circulating adiponectin levels in both sexes. HF or HF + HS diet impaired PVAT anticontractile effects in SMAs from females but not males. PVAT-mediated endothelial dysfunction in SMAs from female mice after 3 months of a HF + HS diet, whereas in males, this effect was observed only after 5 months of HF + HS diet. However, PVAT did not impact acetylcholine-induced relaxation in SMAs from both sexes fed HF diet. The findings suggest that the addition of sucrose to a HF diet accelerates PVAT dysfunction in both sexes. PVAT dysfunction in response to both diets was observed early in females compared to age-matched males suggesting a susceptibility of the female sex to PVAT-mediated vascular complications in the setting of obesity. The data illustrate the importance of the duration and composition of obesogenic diets for investigating sex-specific treatments and pharmacological targets for obesity-induced vascular complications.</p> (AU)

Processo FAPESP: 18/16505-8 - Disfunção e inflamação do tecido adiposo perivascular na obesidade: papel do receptor de mineralocorticoides
Beneficiário:Ana Paula Couto Davel
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/07607-8 - CMPO - Centro Multidisciplinar de Pesquisa em Obesidade e Doenças Associadas
Beneficiário:Licio Augusto Velloso
Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 18/00543-8 - Papel do receptor de mineralocorticoides endoteliais e de macrófagos na resposta inflamatória e função anticontrátil do tecido adiposo perivascular de machos e fêmeas obesos
Beneficiário:Jamaira Aparecida Victorio
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado