| Texto completo | |
| Autor(es): |
Tanaka, Jean Lucas
[1, 2]
;
Costa-Orlandi, Caroline Barcelos
[3]
;
Burd, Betina Sayeg
[1]
;
Pegorin, Giovana Sant'Ana
[1]
;
da Silva, Thaina Venancio
[1]
;
Guerra, Nayrim Brizuela
[4]
;
Soares Mendes-Giannini, Maria Jose
[3]
;
Fusco-Almeida, Ana Marisa
[3]
;
Herculano, Rondinelli Donizetti
[1, 2]
;
de Barros, Natan Roberto
[1, 5]
Número total de Autores: 10
|
| Afiliação do(s) autor(es): | [1] Sao Paulo State Univ UNESP, Bioengn & Biomat Grp, Sch Pharmaceut Sci, Km01 Araraquara Jau Rd, Araraquara, SP - Brazil
[2] Sao Paulo State Univ UNESP, Dept Biotechnol & Bioproc Engn, Sch Pharmaceut Sci, Km01 Araraquara Jau Rd, Araraquara, SP - Brazil
[3] Sao Paulo State Univ UNESP, Dept Clin Anal, Sch Pharmaceut Sci, Km01 Araraquara Jau Rd, Araraquara, SP - Brazil
[4] Univ Caxias do Sul UCS, Area Exact Sci & Engn, 1130 Francisco Getulio Vargas St, Caxias Do Sul, RS - Brazil
[5] Terasaki Inst Biomed Innovat TIBI, 1018 Westwood Blvd, Los Angeles, CA 90024 - USA
Número total de Afiliações: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | International Journal of Biological Macromolecules; v. 189, p. 597-606, OCT 31 2021. |
| Citações Web of Science: | 1 |
| Resumo | |
Millions of people are burned worldwide every year and 265,000 of the cases are fatal. The development of burn treatment cannot consist only of the administration of a single drug. Due to the infection risk, antibiotics are used in conjunction with gels and damp bandages. In this work, an inexpensive curative based on silver sulfadiazine (SS) and natural rubber latex (NRL) was developed to treat burn wounds. It was produced by the casting method. The infrared spectrum presented no interaction between drug and biopolymer. At the same time, electronic micrographs showed that the SS crystals are inserted on the polymeric dressing surface. Mechanical properties after the drug incorporation were considered suitable for dermal application. About 32.4% of loaded SS was released in 192 h by the dressings that also inhibited the growth of Candida albicans and Candida parapsilosis at 75.0 and 37.5 mu g.mL- 1, respectively. The curative proved to be biocompatible when applied to fibroblast cells, in addition to enhancing cellular proliferation and, in the hemocompatibility test, no hemolytic effects were observed. The good results in mechanical, antifungal and biological assays, combined with the average bandage cost of \$0.10, represent an exciting alternative for treating burn wounds. (AU) | |
| Processo FAPESP: | 17/19603-8 - Desenvolvimento de um novo adesivo à base de látex natural reforçado com barbatimão e suas frações e estudo das vias de sinalização do reparo dérmico |
| Beneficiário: | Rondinelli Donizetti Herculano |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 11/17411-8 - Avaliação da liberação controlada de fármacos utilizando membranas de látex natural como carreador |
| Beneficiário: | Rondinelli Donizetti Herculano |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 17/18388-6 - O papel do biofilme na patogênese das dermatofitoses e desenvolvimento de estratégias de combate |
| Beneficiário: | Caroline Barcelos Costa Orlandi |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 14/17526-8 - Desenvolvimento de um novo sistema empregando o látex natural como liberador de extratos vegetais reforçados por nanopartículas: caracterização física, química e biológica |
| Beneficiário: | Rondinelli Donizetti Herculano |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |