Natural rubber dressing loaded with silver sulfadiazine for the treatment of burn wounds infected with Candida spp.

Author(s)

Tanaka, Jean Lucas ^{[1, 2]} ; Costa-Orlandi, Caroline Barcelos ^[3] ; Burd, Betina Sayeg ^[1] ; Pegorin, Giovana Sant'Ana ^[1] ; da Silva, Thaina Venancio ^[1] ; Guerra, Nayrim Brizuela ^[4] ; Soares Mendes-Giannini, Maria Jose ^[3] ; Fusco-Almeida, Ana Marisa ^[3] ; Herculano, Rondinelli Donizetti ^{[1, 2]} ; de Barros, Natan Roberto ^{[1, 5]}

Affiliation

^[1] Sao Paulo State Univ UNESP, Bioengn & Biomat Grp, Sch Pharmaceut Sci, Km01 Araraquara Jau Rd, Araraquara, SP - Brazil

^[2] Sao Paulo State Univ UNESP, Dept Biotechnol & Bioproc Engn, Sch Pharmaceut Sci, Km01 Araraquara Jau Rd, Araraquara, SP - Brazil

^[3] Sao Paulo State Univ UNESP, Dept Clin Anal, Sch Pharmaceut Sci, Km01 Araraquara Jau Rd, Araraquara, SP - Brazil

^[4] Univ Caxias do Sul UCS, Area Exact Sci & Engn, 1130 Francisco Getulio Vargas St, Caxias Do Sul, RS - Brazil

^[5] Terasaki Inst Biomed Innovat TIBI, 1018 Westwood Blvd, Los Angeles, CA 90024 - USA

• Document type: Journal article
• Source: International Journal of Biological Macromolecules; v. 189, p. 597-606, OCT 31 2021.
• Web of Science Citations: 1

Abstract

Millions of people are burned worldwide every year and 265,000 of the cases are fatal. The development of burn treatment cannot consist only of the administration of a single drug. Due to the infection risk, antibiotics are used in conjunction with gels and damp bandages. In this work, an inexpensive curative based on silver sulfadiazine (SS) and natural rubber latex (NRL) was developed to treat burn wounds. It was produced by the casting method. The infrared spectrum presented no interaction between drug and biopolymer. At the same time, electronic micrographs showed that the SS crystals are inserted on the polymeric dressing surface. Mechanical properties after the drug incorporation were considered suitable for dermal application. About 32.4% of loaded SS was released in 192 h by the dressings that also inhibited the growth of Candida albicans and Candida parapsilosis at 75.0 and 37.5 mu g.mL- 1, respectively. The curative proved to be biocompatible when applied to fibroblast cells, in addition to enhancing cellular proliferation and, in the hemocompatibility test, no hemolytic effects were observed. The good results in mechanical, antifungal and biological assays, combined with the average bandage cost of \$0.10, represent an exciting alternative for treating burn wounds. (AU)

• FAPESP's process: 17/19603-8 - Development of a novel patch containing latex and barbatimam e fractions and study of signaling pathways in cutaneous wound repair
• Grantee: Rondinelli Donizetti Herculano
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/17411-8 - Evaluation of drugs delivery systems using natural rubber latex membranes as carrier
• Grantee: Rondinelli Donizetti Herculano
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/18388-6 - Role of biofilm in the pathogenesis of dermatophytosis and development of combat strategies
• Grantee: Caroline Barcelos Costa Orlandi
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 14/17526-8 - Development of a novel system employing natural rubber latex as releasing of vegetable extracts incorporated with nanoparticles: physical chemical and biological characterization
• Grantee: Rondinelli Donizetti Herculano
• Support Opportunities: Regular Research Grants