Incidence of thyroid diseases: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

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Bensenor, Isabela M. ^[1] ; Sgarbi, Jose Augusto ^[2] ; Janovsky, Carolina Castro Porto Silva ^[1] ; Pittito, Bianca Almeida ^[3] ; Diniz, Maria de Fatima Haueisen Sander ^[4] ; Almeida, Maria da Conceicao Chagas de ^[5] ; Alvim, Sheila Maria ^[6] ; Barreto, Sandhi M. ^[7] ; Giatti, Luana ^[7] ; Duncan, Bruce B. ^[8] ; Schmidt, Maria Ines ^[8] ; Fonseca, Maria de Jesus M. ^[9] ; Griep, Rosane H. ^[10] ; Molina, Maria del Carmen B. ^[11] ; Mill, Jose Geraldo ^[12] ; Santos, Itamar de Souza ^[1] ; Goulart, Alessandra C. ^[1] ; Lotufo, Paulo A. ^[1]

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^[1] Univ Sao Paulo, Ctr Pesquisa Clin & Epidemiol, Sao Paulo, SP - Brazil

^[2] Fac Med Marilia, Div Endocrinol, Marilia, SP - Brazil

^[3] Univ Fed Sao Paulo, Dept Med Prevent, Sao Paulo, SP - Brazil

^[4] Univ Fed Minas Gerais UFMG, Fac Med, Belo Horizonte, MG - Brazil

^[5] Fundacao Oswaldo Cruz Fiocruz, Inst Goncalo Moniz, Salvador, BA - Brazil

^[6] Univ Fed Bahia, Inst Saude Colet, Salvador, BA - Brazil

^[7] Univ Fed Minas Gerais, Med Prevent, Belo Horizonte, MG - Brazil

^[8] Univ Fed Rio Grande do Sul, Programa Posgrad Epidemiol, Porto Alegre, RS - Brazil

^[9] Fundacao Oswaldo Cruz, Escola Nacl Saude Publ, Dept Epidemiol & Metodos Quantitat, Rio De Janeiro, RJ - Brazil

^[10] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Educ Saude & Meio Ambiente, Rio De Janeiro, RJ - Brazil

^[11] Univ Fed Espirito Santo, Dept Nutr, Vitoria, ES - Brazil

^[12] Univ Fed Espirito Santo, Dept Ciencias Fisiol, Vitoria, ES - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF ENDOCRINOLOGY METABOLISM; v. 65, n. 4, p. 468-478, JUL-AUG 2021.
• Citações Web of Science: 0

Resumo

ABSTRACT Objective: To evaluate incidence of subclinical and overt hyperthyroidism and hypothyroidism. Subjects and methods: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a prospective cohort study of 15,105 civil servants, examined at baseline and over a 4-year follow-up. This analysis included 9,705 participants with normal thyroid function at baseline, follow-up information about thyroid function and with no report of using drugs that may interfere in the thyroid function. Thyroid function was defined by TSH/FT4 levels or routine use of thyroid hormones/anti-thyroid medications. Annual and cumulative (over 4-year) incidence rates were presented as percentages (95% Confidence Intervals). Results: The incidence of all overt and subclinical thyroid disease was 6.7% (1.73%/year): 0.19% for overt hyperthyroidism (0.048%/year), 0.54% for subclinical hyperthyroidism (0.14%/year), 1.98% for overt hypothyroidism (0.51%/year), and 3.99% for subclinical hypothyroidism (1.03%/year). The incidence of all thyroid diseases was higher in women, when compared to men, with a low women:men ratio (1.36). For Blacks the highest incidence was for overt hyperthyroidism, while for Whites, the highest incidence was for overt hypothyroidism. However, the highest incidence of overt hyperthyroidism was detected in Asian descendants. The presence of antithyroperoxidase antibodies at baseline was associated with higher incidence of overt thyroid diseases. Conclusion: These results showed a high incidence of hypothyroidism, which is compatible with a country with a more-than-adequate iodine intake. The low women:men ratio of the incidence of thyroid dysfunction highlights the importance of the diagnosis of thyroid diseases among men in Brazil. (AU)

• Processo FAPESP: 15/17213-2 - Incidência de doença tireoidiana clínica, subclínica e de anticorpos anti-tireoperoxidase no Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil)
• Beneficiário: Isabela Judith Martins Bensenor
• Modalidade de apoio: Auxílio à Pesquisa - Temático