Prevalence of new psychoactive substances (NPS) in Brazil based on oral fluid analysis of samples collected at electronic music festivals and parties

Autor(es)

da Cunha, Kelly Francisco ^{[1, 2]} ; Oliveira, Karina Diniz ^{[1, 2]} ; Cardoso, Marilia Santoro ^{[1, 2]} ; Furiozo Arantes, Ana Carolina ^{[1, 2]} ; Piras Coser, Pedro Henrique ^[1] ; Lima, Lucas de Noronha ^[1] ; Sampaio Maluf, Ana Cristhina ^{[1, 2, 3]} ; de Castro Comis, Maria Angelica ^[3] ; Huestis, Marilyn A. ^[4] ; Costa, Jose Luiz ^{[5, 2]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Fac Med Sci, UNICAMP, BR-13083859 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Campinas Poison Control Ctr, UNICAMP, BR-13083859 Campinas, SP - Brazil

^[3] Ctr Convivencia E de Lei, ResPire Harm Reduct Project, BR-01019020 Sao Paulo, SP - Brazil

^[4] Thomas Jefferson Univ, Inst Emerging Hlth Profess, Philadelphia, PA 19107 - USA

^[5] Univ Estadual Campinas, Fac Pharmaceut Sci, UNICAMP, BR-13083859 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: DRUG AND ALCOHOL DEPENDENCE; v. 227, OCT 1 2021.
• Citações Web of Science: 0

Resumo

Background: New psychoactive substances (NPS) use is a worldwide public health issue. Knowing the prevalence of NPS guides public health and legal policies to address the problem. The objective of this study was to identify NPS in Brazil through the analysis of oral fluid (OF) samples collected at parties and electronic music festivals. Methods: Anonymous questionnaires and oral fluid samples were collected from volunteers (>= 18 years) who reported the consumption of at least one illicit psychoactive substance in the last 24 h. Oral fluid sample collections occurred at eleven parties and two electronic music festivals over 16 months (2018-2020). Questionnaire answers were matched to oral fluid toxicological results. Results: Of 462 oral fluid samples, 39.2 % were positive for at least one NPS by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The most prevalent NPS was ketamine (29.4 %), followed by methylone (6.1 %) and N-ethylpentylone (4.1 %); however, MDMA was the most commonly identified (88.5 %) illicit psychoactive substance. More than one drug was identified in 79.9 % of samples, with two (34.2 %) and three (23.4 %) substances most commonly observed. Only 5 % of volunteers reported recent NPS consumption. Conclusion: MDMA is still the most common party and electronic music festival drug, although NPS were identified in more than one-third of oral fluid samples. (AU)

• Processo FAPESP: 17/02147-0 - Cromatografia líquida em uma gota e seu acoplamento com espectrometria de massas: estratégias instrumentais, desenvolvimento de materiais, automatização e aplicações analíticas
• Beneficiário: Fernando Mauro Lanças
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/11849-0 - A toxicologia das Novas Substâncias Psicoativas (NSP): epidemiologia do consumo através da análise de amostras de fluido oral e caracterização de seu metabolismo in vitro
• Beneficiário: Kelly Francisco da Cunha
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/00432-1 - A Toxicologia das Novas Substâncias Psicoativas (NSP): epidemiologia do consumo através da análise de amostras de cabelo e fluido oral
• Beneficiário: José Luiz da Costa
• Modalidade de apoio: Auxílio à Pesquisa - Regular