ympathetic nerve-adipocyte interactions in response to acute stres

Autor(es):Mostrar menos -

Santos, Gabryella S. P. ^[1] ; Costa, Alinne C. ^[1] ; Picoli, Caroline C. ^[1] ; Rocha, Beatriz G. S. ^[1] ; Sulaiman, Sheu O. ^[1] ; Radicchi, Debora C. ^[1] ; Pinto, Mauro C. X. ^[2] ; Batista, Jr., Miguel L. ^{[3, 4]} ; Amorim, Jaime H. ^[5] ; Azevedo, Vasco A. C. ^[6] ; Resende, Rodrigo R. ^[7] ; Camara, Niels O. S. ^[8] ; Mintz, Akiva ^[9] ; Birbrair, Alexander ^{[1, 9]}

Afiliação do(s) autor(es)

^[1] Univ Fed Minas Gerais, Dept Pathol, Belo Horizonte, MG - Brazil

^[2] Univ Fed Goias, Lab Neuropharmacol, Goiania, Go - Brazil

^[3] Boston Univ, Sch Med, Dept Biochem, Boston, MA 02118 - USA

^[4] Univ Mogi das Cruzes, Lab Adipose Tissue Biol, Mogi Das Cruzes, SP - Brazil

^[5] Fed Univ Western Bahia, Ctr Biol Sci & Hlth, Barreiras, BA - Brazil

^[6] Univ Fed Minas Gerais, Dept Genet Ecol & Evolut, Cellular & Mol Genet Lab, Belo Horizonte, MG - Brazil

^[7] Univ Fed Minas Gerais, Dept Biochem & Immunol, Belo Horizonte, MG - Brazil

^[8] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Lab Transplantat Immunobiol, Sao Paulo, SP - Brazil

^[9] Columbia Univ, Dept Radiol, Med Ctr, New York, NY 10032 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: JOURNAL OF MOLECULAR MEDICINE-JMM; v. 100, n. 2 NOV 2021.
• Citações Web of Science: 1

Resumo

Psychological stress predisposes our body to several disorders. Understanding the cellular and molecular mechanisms involved in the physiological responses to psychological stress is essential for the success of therapeutic applications. New studies show, by using in vivo inducible Cre/loxP-mediated approaches in combination with pharmacological blockage, that sympathetic nerves, activated by psychological stress, induce brown adipocytes to produce IL-6. Strikingly, this cytokine promotes gluconeogenesis in hepatocytes, that results in the decline of tolerance to inflammatory organ damage. The comprehension arising from this research will be crucial for the handling of many inflammatory diseases. Here, we review recent advances in our comprehension of the sympathetic nerve-adipocyte axis in the tissue microenvironment. (AU)

• Processo FAPESP: 18/20905-1 - TLR4 como crossroad da inflamação e metabolismo energético: Papel do tecido adiposo na síndrome de caquexia
• Beneficiário: Miguel Luiz Batista Junior
• Modalidade de apoio: Bolsas no Exterior - Pesquisa