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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

caling up xylitol bioproduction: Challenges to achieve a profitable bioproces

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Autor(es):
Queiroz, Sarah S. [1] ; Jofre, Fanny M. [1] ; Mussatto, I, Solange ; Felipe, Maria das Gracas A. [1]
Número total de Autores: 4
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Engn Sch Lorena, Dept Biotechnol, Estr Municipal Campinho S-N, Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: RENEWABLE & SUSTAINABLE ENERGY REVIEWS; v. 154, FEB 2022.
Citações Web of Science: 0
Resumo

Xylitol is a GRAS (Generally Recognized as Safe) polyol commonly used in the food industry and able to promote several benefits to the health. In addition, it can also be used as a building block molecule for the manufacture of different high-value chemicals. Currently, the commercial production of xylitol occurs by chemical route through the catalytic hydrogenation of xylose from lignocellulosic biomass. Since this is an expensive process due to the severe reactional conditions employed, the biotechnological route for xylitol production, which comprises the biological conversion of xylose into xylitol, emerges as a potential lower-cost alternative to obtain this polyol due to the milder process conditions required. However, the biotechnological route still presents important bottlenecks and challenges that impairs the process scaling up. Modern strategies and technologies that can potentially improve xylitol bioproduction include adaptive evolution of microbial strains to enhance their tolerance to inhibitors and the xylose uptake rate during the fermentation step; development of engineered microorganisms to result in higher xylose-to-xylitol bioconversion yields; as well as xylitol purification techniques to improve the recovery yields. Moreover, techno-economic analysis of the overall production chain is essential to identify the process viability for large-scale implementation as well as the steps requiring improvements. These are some key factors discussed in this review, which aims to provide insights for the development of a more economically competitive, less energy demanding and scalable new technology for xylitol production. (AU)

Processo FAPESP: 19/27092-9 - Biorrefinaria de produção de xilitol a partir de cana-de-açúcar: novas estratégias para viabilizar a rota biotecnológica
Beneficiário:Maria das Graças de Almeida Felipe
Modalidade de apoio: Auxílio à Pesquisa - Programa BIOEN - Regular