Bioadhesive liquid crystal systems for octyl methoxycinnamate skin delivery

Autor(es)

do Prado, Alice Haddad ^[1] ; Duarte, Jonatas Lobato ^[1] ; Di Filippo, Leonardo Delello ^[1] ; Victorelli, Francesca Damiani ^[1] ; de Abreu Fantini, Marcia Carvalho ^[2] ; Peccinini, Rosangela Gonacalves ^[1] ; Chorilli, Marlus ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, Rodovia Araraquara Jau, Km 1, BR-14801902 Araraquara, SP - Brazil

^[2] Univ Sao Paulo, Inst Phys, BR-05315970 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF MOLECULAR LIQUIDS; v. 345, JAN 1 2022.
• Citações Web of Science: 0

Resumo

Excessive exposure to ultraviolet radiation stemmed from sunlight can cause harm to human skin. An alternative to avoid and reduce the effects of ultraviolet radiation is the use of sunscreens. The sunscreen octyl methoxycinnamate (OMC) is one of the most used filters globally. Still, studies have indicated systemic absorption of this product and subsequent amendment and impaired functioning of the endocrine system. Surfactant systems as liquid crystals systems are used to improve the delivery and efficacy of active ingredients. The OMC incorporated into liquid crystals can have greater retention in the skin's outer layers and lower percutaneous absorption, avoiding their harmful systemic effects. This work aimed to develop and characterize surfactant-based systems for OMC skin delivery and evaluate the in vitro skin permeation and retention properties. Polarized light microscopy and SAXS showed that the selected formulations presented cubic mesophases. The formulations presented pseudoplastic behaviour and the Fl and Fl F formulations presented the highest viscosity of all formulations. The three formulations presented controlled release over time, being the F2F and F3F presenting high release rates when compared to Fl F. The formulation F3F presented the higher stratum corneum retention and lower epidermis and dermis retention when compared to Fl F and F2F. The formultions manteined the sun protecting factor of OMC, being similar to the finds in the literature for this sunscreen. Thus, the bioadhesive LCS developed in this work have great potential for OMC delivery to the skin. (C) 2021 Published by Elsevier B.V. (AU)

• Processo FAPESP: 16/24531-3 - Propriedades estruturais e biofísicas de lipoproteínas nativa e modificada
• Beneficiário: Antonio Martins Figueiredo Neto
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/22426-2 - Carreadores lipídicos nanoestruturados como potencial estratégia para incorporação do p-metoxicinamato de octila: desenvolvimento, caracterização físico-química e ensaios biológicos in vitro
• Beneficiário: Alice Haddad Do Prado
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 17/17844-8 - Sílica nanoestruturada como veículo protetor de vacinas e biomoléculas
• Beneficiário: Osvaldo Augusto Brazil Esteves Sant'Anna
• Modalidade de apoio: Auxílio à Pesquisa - Temático