Bioadhesive liquid crystal systems for octyl methoxycinnamate skin delivery

Author(s)

do Prado, Alice Haddad ^[1] ; Duarte, Jonatas Lobato ^[1] ; Di Filippo, Leonardo Delello ^[1] ; Victorelli, Francesca Damiani ^[1] ; de Abreu Fantini, Marcia Carvalho ^[2] ; Peccinini, Rosangela Gonacalves ^[1] ; Chorilli, Marlus ^[1]

Affiliation

^[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, Rodovia Araraquara Jau, Km 1, BR-14801902 Araraquara, SP - Brazil

^[2] Univ Sao Paulo, Inst Phys, BR-05315970 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: JOURNAL OF MOLECULAR LIQUIDS; v. 345, JAN 1 2022.
• Web of Science Citations: 0

Abstract

Excessive exposure to ultraviolet radiation stemmed from sunlight can cause harm to human skin. An alternative to avoid and reduce the effects of ultraviolet radiation is the use of sunscreens. The sunscreen octyl methoxycinnamate (OMC) is one of the most used filters globally. Still, studies have indicated systemic absorption of this product and subsequent amendment and impaired functioning of the endocrine system. Surfactant systems as liquid crystals systems are used to improve the delivery and efficacy of active ingredients. The OMC incorporated into liquid crystals can have greater retention in the skin's outer layers and lower percutaneous absorption, avoiding their harmful systemic effects. This work aimed to develop and characterize surfactant-based systems for OMC skin delivery and evaluate the in vitro skin permeation and retention properties. Polarized light microscopy and SAXS showed that the selected formulations presented cubic mesophases. The formulations presented pseudoplastic behaviour and the Fl and Fl F formulations presented the highest viscosity of all formulations. The three formulations presented controlled release over time, being the F2F and F3F presenting high release rates when compared to Fl F. The formulation F3F presented the higher stratum corneum retention and lower epidermis and dermis retention when compared to Fl F and F2F. The formultions manteined the sun protecting factor of OMC, being similar to the finds in the literature for this sunscreen. Thus, the bioadhesive LCS developed in this work have great potential for OMC delivery to the skin. (C) 2021 Published by Elsevier B.V. (AU)

• FAPESP's process: 16/24531-3 - Structural and biophysics properties of native and modified lipoproteins
• Grantee: Antonio Martins Figueiredo Neto
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 14/22426-2 - Nanostructured lipid carriers as a potential strategy for incorporation of octyl methoxycinnamate: development, physicochemical characterization and in vitro biological assays
• Grantee: Alice Haddad Do Prado
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 17/17844-8 - Nanostructured silica as a protective vehicle for vaccines and biomolecules
• Grantee: Osvaldo Augusto Brazil Esteves Sant'Anna
• Support Opportunities: Research Projects - Thematic Grants