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Nanostructured lipid carriers as a potential strategy for incorporation of octyl methoxycinnamate: development, physicochemical characterization and in vitro biological assays

Grant number: 14/22426-2
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2015
Effective date (End): February 29, 2016
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Marlus Chorilli
Grantee:Alice Haddad Do Prado
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

The human skin exposure to sunlight can cause damage such as erythema, cancer and premature aging of the skin. One of the ways to protect the skin and, consequently, decrease these effects, is the use of sunscreens, as the Octyl Methoxycinnamate (OMC) witch has been very used in photoprotective formulations because of their spectrum against Ultraviolet Radiation (UV) B. For action of sunscreen, it is extremely important to their permanence in the outer layers of the epidermis. However, some studies have detected the OMC in samples of blood, urine and milk after topical application of conventional formulations containing this filter, indicating systemic exposure.In this way, it becomes convenient the study an appropriate carrier which allow adequate dermal retention for this filter. Nanostructured lipid systems, such as Nanostructured Lipid Carriers (NLCs) are gaining notoriety as carriers for dermal administration due to its ability to interact with the stratum corneum, allowing greater retention of active substances. Thus, the incorporation of OMC in NLC may be convenient, in order to favor the persistence of this filter in the upper layers of the skin and hence promote greater protection against UV rays. In this project we intend to develop, characterize and evaluate the in vitro biological effects of incorporation of OMC in NLCs, in order to optimize its photoprotective effect and its preventive action against skin aging and cancer. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DO PRADO, ALICE HADDAD; DUARTE, JONATAS LOBATO; DI FILIPPO, LEONARDO DELELLO; VICTORELLI, FRANCESCA DAMIANI; DE ABREU FANTINI, MARCIA CARVALHO; PECCININI, ROSANGELA GONACALVES; CHORILLI, MARLUS. Bioadhesive liquid crystal systems for octyl methoxycinnamate skin delivery. JOURNAL OF MOLECULAR LIQUIDS, v. 345, JAN 1 2022. Web of Science Citations: 0.
DO PRADO, ALICE HADDAD; SOUSA ARAUJO, VICTOR HUGO; ELOY, JOSIMAR O.; FONSECA-SANTOS, BRUNO; PEREIRA-DA-SILVA, MARCELO A.; PECCININI, ROSANGELA GONCALVES; CHORILLI, MARLUS. Synthesis and Characterization of Nanostructured Lipid Nanocarriers for Enhanced Sun Protection Factor of Octyl p-methoxycinnamate. AAPS PHARMSCITECH, v. 21, n. 4 APR 29 2020. Web of Science Citations: 0.
PRADO, A. H.; BORGES, M. C.; ELOY, J. O.; PECCININI, R. G.; CHORILLI, M. An ultra-high performance liquid chromatography method to determine the skin penetration of an octyl methoxycinnamate-loaded liquid crystalline system. Pharmazie, v. 72, n. 10, p. 563-567, OCT 2017. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.