Desenvolvimento e caracterização de sistemas líquido-cristalinos contendo p-metoxicinamato de octila: avaliação da permeação e retenção cutânea in vitro

• Grant number: 13/00485-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): March 01, 2013
• Effective date (End): February 28, 2014
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Marlus Chorilli
• Grantee: Alice Haddad Do Prado
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Human skin exposure to sunlight can cause damage such as erythema, cancer, and premature aging of the skin. One of the ways to protect the skin and, consequently, decrease these effects, is the use of sunscreens, as octyl methoxycinnamate (OMC). The OMC is an organic sunscreen that has a spectrum against UVB rays and has been very used in photoprotective formulations. For the real action of sunscreen, it is extremely important to their permanence in the outer layers of the epidermis, in order to avoid systemic effects. Some studies have detected the OMC in samples of blood, urine, and milk after topical application of conventional semi-solid formulations, indicating systemic exposure. In this way, it becomes convenient the study an appropriate carrier for the OMC, to permit a high retention skin. Drug delivery systems based on nanotechnology, including liquid-crystalline systems, are able to increase the retention of the compound in the outer layers of the skin, which in turn will allow for greater protection against UV rays. The present work aims at the development of nanostructured systems consisting of silicones with OMC and evaluation of permeation and cutaneous retention of this compound in vitro. The expected of this study is to obtain a drug delivery system of nanostructural level for the OMC to increase its retention in the outer skin layers. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PRADO, A. H.; BORGES, M. C.; ELOY, J. O.; PECCININI, R. G.; CHORILLI, M.. An ultra-high performance liquid chromatography method to determine the skin penetration of an octyl methoxycinnamate-loaded liquid crystalline system. Pharmazie, v. 72, n. 10, p. 563-567, OCT 2017. (13/00485-4, 14/22426-2)