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Structural and biophysics properties of native and modified lipoproteins

Grant number: 16/24531-3
Support type:Research Projects - Thematic Grants
Duration: October 01, 2017 - September 30, 2022
Field of knowledge:Physical Sciences and Mathematics - Physics
Principal Investigator:Antonio Martins Figueiredo Neto
Grantee:Antonio Martins Figueiredo Neto
Home Institution: Instituto de Física (IF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Co-Principal Investigators:Cristiano Luis Pinto de Oliveira ; Nágila Raquel Teixeira Damasceno
Assoc. researchers: Alessandro Desideri ; Andrew John Masters ; Cassio Alves ; Daniel Erik Otzen ; Erol Akpinar ; Francisco Antonio Helfenstein Fonseca ; Giovanni Barbero ; Jan Skov Pedersen ; Luis Eduardo Soares Netto ; Maria Aparecida Neves Jardini ; Maria Cristina de Oliveira Izar ; Maria Helena Godinho ; Matthias Epple ; Nágila Raquel Teixeira Damasceno ; Nallet ; Prymak Oleg ; Roberto Kopke Salinas ; Samantha Cristina de Pinho ; Silvia Biocca ; Stefan K. Nilsson
Associated grant(s):19/00560-2 - A study on lyotropic biaxial chromonic nematic phases via polarising light microscopy, laser conoscopy and small-angle x-ray scattering, AV.EXT
19/03720-0 - 87th European atherosclerosis society Congress, AR.EXT
17/20992-9 - Multi user equipment approved in the grant 2016/24531-3: upgrade of the X-ray diffractometer of the laboratory, increasing the scattering vector modulus range and versatile source with three wavelengths controlled by software, AP.EMU
Associated scholarship(s):19/10433-8 - Simulation and structural modeling of oriented liquid crystals using small-angle scattering Methodsng, BP.PD
18/07340-5 - Structural characterisation of lipoproteins, BP.PD


This project joins researchers from different areas as Physics, Medicine, Odontology and Nutrition on the description of problems that needs multidisciplinary focus as the investigation of complex fluids and elastomers. Frontier knowledge will be obtained on the relationship of molecular and nanoparticle interactions which are directly related to the complex behavior of magnetic colloids, liquid crystals, elastomers and supramolecular assemblies of biologic and biochemical interest. The obtained results can provide the development of feed protocols and diagnostic methodologies of Arteriosclerosis and its relationship with Periodontitis and Diabetes. The team consists of researchers and collaborators with large experience on multidisciplinary work and joint publications. Several experimental techniques will be used covering linear and non-linear optics, x-ray diffraction and scattering and calorimetry. Our targets are self-assembly multicomponent systems on thermodynamic equilibrium as liquid crystals, magnetic colloids, micelles, protein-surfactant complexes and human lipoproteins and elastomers. In some cases, model systems on controlled conditions will be investigated in order to provide information on the intricate structure-function-dynamics relationship. The study of lipoproteins, on different in vivo conditions, may provide information on the oxidative processes and its implications on Atherosclerosis. The influence of pathologies like diabetes and periodontitis on the lipoproteins morphology and immune response will be investigated before and after specific interventions. The effect of omega-3 will be investigated on clinic trials in order to determine its influence on the health conditions of adults. The influence of periodontitis on the cardiovascular markers of patients with Diabetes Mellitus will be investigated. In addition, the benefits of the intake of biomass like green-banana by those patients will be evaluated and correlated to the characteristics of the lipoproteins. The research will be supported by nutritionist, who will determine the evolution of the lipid profile of each patient as well as the optic and structural properties of its lipoproteins will be determined before and after the intervention. Thermodynamic and structural characterization of amphiphilic systems and protein-surfactant complexes will be performed using calorimetry and spectroscopic techniques. An innovative approach is applied on these investigations and provides the basis for a quantitative description. Investigations on the interactions between lipids and small molecules will be performed. In this type of study it is necessary the determination of the binding affinity, absorption of the molecule on the lipid membrane as well as the induced structural changes on the overall structure. The study of proteins in directly in solution, which can be performed by x-ray scattering and light scattering, will permit the determination of structural parameters of the macromolecules close to native, in vivo, situation. The project proposes the investigation of physical, chemical and biological properties metallic nanoparticles with several sizes and shapes. The nanoparticles nucleation processes will be investigated and correlated to its general properties. One of our goals is to synthetize and characterizes new celluloid based materials with unique optical properties like the selective reflection of light. Those materials may have tunable photonic structure, either by the use of external electric field or temperature variation. Thermotropic liquid crystals molecules will be added to the celluloid based material in order to enhance structural and optical properties. New elastomeric materials will be synthetized based on PU/PBDO chains with and without the incorporation of magnetic nanoparticles. The mechanical and structural characteristics will be investigated with several experimental complementary techniques, in particular SAXS and DLS. (AU)

Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AKPINAR, EROL; GUNER, EMRE; DEMIR-ORDU, OZNUR; FIGUEIREDO NETO, ANTONIO MARTINS. Effect of head-group size of some tetradecylalkylammonium bromide surfactants on obtaining the lyotropic biaxial nematic phase. EUROPEAN PHYSICAL JOURNAL E, v. 42, n. 4 APR 2019. Web of Science Citations: 0.
AKPINAR, EROL; FIGUEIREDO NETO, ANTONIO MARTINS. Experimental Conditions for the Stabilization of the Lyotropic Biaxial Nematic Mesophase. CRYSTALS, v. 9, n. 3 MAR 19 2019. Web of Science Citations: 0.
PAREK, KINNARI; ESPINOSA, DANIEL H. G.; REIS, DENNYS; DE OLIVEIRA, CRISTIANO L. P.; WLYSSES, WAGNER; FIGUEIREDO NETO, ANTONIO MARTINS. Morphological metamorphosis of magnetic nanoparticles due to the presence of rare earth atoms in the spinel structure: From spheres to cubes. Materials Chemistry and Physics, v. 222, p. 217-226, JAN 15 2019. Web of Science Citations: 0.
DE QUEIROZ MELLO, ANA PAULA; ALBATTARNI, GHADEER; GARCIA ESPINOSA, DANIEL HUMBERTO; REIS, DENNYS; FIGUEIREDO NETO, ANTONIO MARTINS. Structural and Nonlinear Optical Characteristics of In Vitro Glycation of Human Low-Density Lipoprotein, as a Function of Time. Brazilian Journal of Physics, v. 48, n. 6, p. 560-570, DEC 2018. Web of Science Citations: 0.

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