Structural characterisation of lipoproteins

• Grant number: 18/07340-5
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: July 01, 2018
• End date: June 30, 2022
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Principal Investigator: Antonio Martins Figueiredo Neto
• Grantee: Zahra Lotfollahi
• Host Institution: Instituto de Física (IF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 16/24531-3 - Structural and biophysics properties of native and modified lipoproteins, AP.TEM

Abstract

Lipoproteins are essential biological structures for metabolism. They are divided into several classes depending on their size and density: VLDL (Very Low Density Lipoproteins), LDL (Low Density Lipoproteins), HDL (High Density Lipoproteins). These structures, typically of tens of nanometers, have several biological functions, one of the main ones being cholesterol transport, which is insoluble in aqueous medium, in the circulatory system. The quantification of LDL and HDL in the body, among other lipid indicators, is used as an indicator of the health of the individual. In addition, it is known that oxidation of LDL is related to the formation of atherosclerotic plaques, which in turn can lead to heart disease. Recently we have presented methodologies and protocols of analysis and modeling for X-ray scattering data at low angles and nonlinear lipoprotein optical experiments in solution for various medium conditions (oxidation levels, temperature, etc.). This approach, which is innovative in the literature, allows the obtaining of detailed structural information about these structures as well as indications of changes induced by oxidation. In this project we intend to optimize experimental data analysis and modeling data from the Z-scan (non-linear optical technique) in the millisecond time scale in order to allow the structural characterization of lipoproteins and their states of modification/aggregation. This aggregation, which can be induced by levels of oxidation, temperature or other agents, can serve as an indicator of atherosclerotic plaque formation processes in real systems. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TATIANE CAROLINE DE SOUZA RAMOS; MARIÉLLEN LONGO VILAS BOAS; CAMILLA MAGNONI MORETTO NUNES; CAMILA LOPES FERREIRA; CLÁUDIO MENDES PANNUTI; MAURO PEDRINE SANTAMARIA; MARIA APARECIDA NEVES JARDINI. Effect of systemic antibiotic and probiotic therapies as adjuvant treatments of subgingival instrumentation for periodontitis: a randomized controlled clinical study. Journal of Applied Oral Science, v. 30, 2022-03-23. (18/07340-5, 14/50983-3)

VIANA MIGUEL, MANUELA MARIA; MATHIAS-SANTAMARIA, INGRID FERNANDES; ROSSATO, AMANDA; FERREIRA FERRAZ, LAIS FERNANDA; FIGUEIREDO-NETO, ANTONIO MARTINS; DE MARCO, ANDREA CARVALHO; VIANA CASARIN, RENATO CORREA; WALLET, SHANNON MARGARET; TATAKIS, DIMITRIS N.; MATHIAS, MARCIO ANTONIO; et al. Microcurrent electrotherapy improves palatal wound healing: Randomized clinical trial. Journal of Periodontology, v. 92, n. 2, AUG 2020. (18/03353-5, 18/07340-5, 16/16102-5, 16/07528-9, 16/24531-3, 14/50983-3)

LOTFOLLAHI, ZAHRA; MELLO, ANA P. Q.; FONSECA, FRANCISCO A. H.; MACHADO, LUCIENE O.; MATHIAS, ANDRESSA F.; IZAR, MARIA C.; DAMASCENO, NAGILA R. T.; OLIVEIRA, CRISTIANO L. P.; NETO, ANTONIO M. F.. Changes in lipoproteins associated with lipid-lowering and antiplatelet strategies in patients with acute myocardial infarction. PLoS One, v. 17, n. 8, p. 19-pg., 2022-08-30. (12/51692-7, 16/24531-3, 18/07340-5)

NUNES, CAMILLA MAGNONI MORETTO; FERREIRA, CAMILA LOPES; BERNARDO, DANIELLA VICENSOTTO; LOPES, CASSIA CAROLINA RABELO; COLLINO, LUMA; DA SILVA LIMA, VICTORIA CLARA; DE CAMARGO REIS MELLO, DAPHNE; DE VASCONCELLOS, LUANA MAROTTA REIS; JARDINI, MARIA APARECIDA NEVES. Evaluation of pulsed electromagnetic field protocols in implant osseointegration: in vivo and in vitro study. CLINICAL ORAL INVESTIGATIONS, v. 25, n. 5, p. 13-pg., 2020-10-09. (14/50983-3, 18/07340-5)

PEDROSO, JULIANA DE FATIMA; LOTFOLLAHI, ZAHRA; ALBATTARNI, GHADEER; SCHULZ, MAIARA ARRRUDA; MONTEIRO, ANDREA; SEHNEM, ANDRE LUIZ; GIDLUND, MAGNUS AKE; FIGUEIREDO NETO, ANTONIO MARTINS; NEVES JARDINI, MARIA APARECIDA. Influence of Periodontal Disease on cardiovascular markers in Diabetes Mellitus patients. SCIENTIFIC REPORTS, v. 9, NOV 6 2019. (16/24531-3, 14/50983-3, 18/07340-5)

AKPINAR, EROL; TOPCU, GOKHAN; REIS, DENNYS; FIGUEIREDO NETO, ANTONIO MARTINS. Effect of the anionic azo dye Sunset Yellow in lyotropic mixtures with uniaxial and biaxial nematic phases. JOURNAL OF MOLECULAR LIQUIDS, v. 318, NOV 15 2020. (18/07340-5, 16/24531-3, 14/50983-3)