Nonylphenol and cyproterone acetate effects in the liver and gonads of Lithobates catesbeianus (Anura) tadpoles and juveniles

Autor(es)

de Gregorio, Lara Salgueiro ^{[1, 2]} ; Franco-Belussi, Lilian ^{[3, 4]} ; Goldberg, Javier ^[5] ; De Oliveira, Classius ^[3]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ UNESP, Postgrad Program Biodivers, Dept Biol, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

^[2] UNESP, Dept Biol, Inst Biociencias Letras & Ciencias Exatas, IBILCE, Rua Cristovio Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

^[3] Sao Paulo State Univ UNESP, Dept Biol, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

^[4] Fed Univ Mato Grosso do Sul UFMS, Lab Expt Pathol LAPEx, Inst Biosci INBIO, BR-79002970 Campo Grande, MS - Brazil

^[5] Univ Nacl Cordoba, Lab Biol Comportamiento, Fac Ciencias Exactas Fis & Nat, CONICET, Inst Diversidad & Ecol Anim IDEA, Velez Sfirsfield 299, CP X5000JJC, Cordoba - Argentina

• Tipo de documento: Artigo Científico
• Fonte: Environmental Science and Pollution Research; v. 28, n. 44, p. 62593-62604, NOV 2021.
• Citações Web of Science: 0

Resumo

Environmental pollution plays an important role in amphibian population decline. Contamination with endocrine disrupting chemicals (EDCs) is particularly worrying due to their capacity to adversely affect organisms at low doses. We hypothesized that exposure to EDCs such as 4-nonylphenol (NP) and cyproterone acetate (CPA) could trigger responses in the liver and gonads, due to toxic and endocrine disrupting effects. Growth rate may also be impaired by contamination. We investigated sublethal effects of a 28-day exposure to three different concentrations of NP and CPA on liver pigmentation, gonadal morphology, body mass, and length of tadpoles and juveniles Lithobates catesbeianus. Liver pigmentation and the gonadal morphologies of treated tadpoles did not differ from control, but growth rate was impaired by both pollutants. Juveniles treated with 10 mu g/L NP and 0.025 and 0.25 ng/L CPA displayed increased liver melanin pigmentation, but gonadal morphologies, sex ratios, and body mass were not affected after treatments. The increase in liver pigmentation may be related to defensive, cytoprotective role of melanomacrophages. The decreased growth rate in tadpoles indicates toxic effects of NP and CPA. Thus, contamination with NP and CPA remains a concern and sublethal effects of different dosages of the compounds on native species should be determined. (AU)

• Processo FAPESP: 18/01078-7 - O fígado de anfíbios anuros: morfologia comparada entre 10 espécies e ação do benzopireno nos melanomacrófagos de Physalaemus cuvieri
• Beneficiário: Classius de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/12006-9 - Influência de contaminantes ambientais (Acetato de ciproterona e Nonilfenol) e fatores abióticos (Temperatura e Radiação UV) na Melanina interna em anfíbios anuros
• Beneficiário: Classius de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/00946-4 - Pigmentação Visceral em Animais Ectotérmicos: Imunidade Inata e Defesa contra UV
• Beneficiário: Lilian Franco Belussi
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado