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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nonylphenol and cyproterone acetate effects in the liver and gonads of Lithobates catesbeianus (Anura) tadpoles and juveniles

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Author(s):
de Gregorio, Lara Salgueiro [1, 2] ; Franco-Belussi, Lilian [3, 4] ; Goldberg, Javier [5] ; De Oliveira, Classius [3]
Total Authors: 4
Affiliation:
[1] Sao Paulo State Univ UNESP, Postgrad Program Biodivers, Dept Biol, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[2] UNESP, Dept Biol, Inst Biociencias Letras & Ciencias Exatas, IBILCE, Rua Cristovio Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[3] Sao Paulo State Univ UNESP, Dept Biol, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[4] Fed Univ Mato Grosso do Sul UFMS, Lab Expt Pathol LAPEx, Inst Biosci INBIO, BR-79002970 Campo Grande, MS - Brazil
[5] Univ Nacl Cordoba, Lab Biol Comportamiento, Fac Ciencias Exactas Fis & Nat, CONICET, Inst Diversidad & Ecol Anim IDEA, Velez Sfirsfield 299, CP X5000JJC, Cordoba - Argentina
Total Affiliations: 5
Document type: Journal article
Source: Environmental Science and Pollution Research; v. 28, n. 44, p. 62593-62604, NOV 2021.
Web of Science Citations: 0
Abstract

Environmental pollution plays an important role in amphibian population decline. Contamination with endocrine disrupting chemicals (EDCs) is particularly worrying due to their capacity to adversely affect organisms at low doses. We hypothesized that exposure to EDCs such as 4-nonylphenol (NP) and cyproterone acetate (CPA) could trigger responses in the liver and gonads, due to toxic and endocrine disrupting effects. Growth rate may also be impaired by contamination. We investigated sublethal effects of a 28-day exposure to three different concentrations of NP and CPA on liver pigmentation, gonadal morphology, body mass, and length of tadpoles and juveniles Lithobates catesbeianus. Liver pigmentation and the gonadal morphologies of treated tadpoles did not differ from control, but growth rate was impaired by both pollutants. Juveniles treated with 10 mu g/L NP and 0.025 and 0.25 ng/L CPA displayed increased liver melanin pigmentation, but gonadal morphologies, sex ratios, and body mass were not affected after treatments. The increase in liver pigmentation may be related to defensive, cytoprotective role of melanomacrophages. The decreased growth rate in tadpoles indicates toxic effects of NP and CPA. Thus, contamination with NP and CPA remains a concern and sublethal effects of different dosages of the compounds on native species should be determined. (AU)

FAPESP's process: 18/01078-7 - The liver of anuran amphibians: morphology compared between 10 species and action of benzopyrene in the melanomacrophages of Physalaemus cuvieri
Grantee:Classius de Oliveira
Support Opportunities: Regular Research Grants
FAPESP's process: 15/12006-9 - The influence of environmental contaminants (cyproterone acetate and nonylphenol) and abiotic factors (temperature and UV radiation) in the internal Melanin in anurans
Grantee:Classius de Oliveira
Support Opportunities: Regular Research Grants
FAPESP's process: 14/00946-4 - Internal Pigmentation in Ectotherms: Innate immunity and UV defense
Grantee:Lilian Franco Belussi
Support Opportunities: Scholarships in Brazil - Post-Doctoral