Mitochondria as a Cellular Hub in Infection and Inflammation

Autor(es)

Andrieux, Pauline ^[1] ; Chevillard, Christophe ^[1] ; Cunha-Neto, Edecio ^{[2, 3]} ; Nunes, Joao Paulo Silva ^{[1, 2, 3]}

Afiliação do(s) autor(es)

^[1] Aix Marseille Univ, TAGC Theories & Approaches Genom Complex, INSERM, UMR 1090, Inst MarMaRa, F-13288 Marseille - France

^[2] Univ Sao Paulo, Sch Med, Div Clin Immunol & Allergy, Lab Immunol, Heart Inst InCor, BR-05403000 Sao Paulo - Brazil

^[3] INCT, Inst Invest Immunol, BR-05403000 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 22, n. 21 NOV 2021.
• Citações Web of Science: 0

Resumo

Mitochondria are the energy center of the cell. They are found in the cell cytoplasm as dynamic networks where they adapt energy production based on the cell's needs. They are also at the center of the proinflammatory response and have essential roles in the response against pathogenic infections. Mitochondria are a major site for production of Reactive Oxygen Species (ROS; or free radicals), which are essential to fight infection. However, excessive and uncontrolled production can become deleterious to the cell, leading to mitochondrial and tissue damage. Pathogens exploit the role of mitochondria during infection by affecting the oxidative phosphorylation mechanism (OXPHOS), mitochondrial network and disrupting the communication between the nucleus and the mitochondria. The role of mitochondria in these biological processes makes these organelle good targets for the development of therapeutic strategies. In this review, we presented a summary of the endosymbiotic origin of mitochondria and their involvement in the pathogen response, as well as the potential promising mitochondrial targets for the fight against infectious diseases and chronic inflammatory diseases. (AU)

• Processo FAPESP: 14/50890-5 - INCT 2014: Investigação em Imunologia
• Beneficiário: Jorge Elias Kalil Filho
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 13/50302-3 - Identificação de uma assinatura genética preditiva / prognóstica na Doença de Chagas: abordagem de biologia de sistemas
• Beneficiário: Edecio Cunha Neto
• Modalidade de apoio: Auxílio à Pesquisa - Regular