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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mitochondria as a Cellular Hub in Infection and Inflammation

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Author(s):
Andrieux, Pauline [1] ; Chevillard, Christophe [1] ; Cunha-Neto, Edecio [2, 3] ; Nunes, Joao Paulo Silva [1, 2, 3]
Total Authors: 4
Affiliation:
[1] Aix Marseille Univ, TAGC Theories & Approaches Genom Complex, INSERM, UMR 1090, Inst MarMaRa, F-13288 Marseille - France
[2] Univ Sao Paulo, Sch Med, Div Clin Immunol & Allergy, Lab Immunol, Heart Inst InCor, BR-05403000 Sao Paulo - Brazil
[3] INCT, Inst Invest Immunol, BR-05403000 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 22, n. 21 NOV 2021.
Web of Science Citations: 0
Abstract

Mitochondria are the energy center of the cell. They are found in the cell cytoplasm as dynamic networks where they adapt energy production based on the cell's needs. They are also at the center of the proinflammatory response and have essential roles in the response against pathogenic infections. Mitochondria are a major site for production of Reactive Oxygen Species (ROS; or free radicals), which are essential to fight infection. However, excessive and uncontrolled production can become deleterious to the cell, leading to mitochondrial and tissue damage. Pathogens exploit the role of mitochondria during infection by affecting the oxidative phosphorylation mechanism (OXPHOS), mitochondrial network and disrupting the communication between the nucleus and the mitochondria. The role of mitochondria in these biological processes makes these organelle good targets for the development of therapeutic strategies. In this review, we presented a summary of the endosymbiotic origin of mitochondria and their involvement in the pathogen response, as well as the potential promising mitochondrial targets for the fight against infectious diseases and chronic inflammatory diseases. (AU)

FAPESP's process: 14/50890-5 - INCT of Investigation in Immunology
Grantee:Jorge Elias Kalil Filho
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 13/50302-3 - Identification of predictive / prognostic genetic signature in Chagas cardiomyopathy: a systems biology approach
Grantee:Edecio Cunha Neto
Support Opportunities: Regular Research Grants