| Texto completo | |
| Autor(es): |
Número total de Autores: 2
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| Afiliação do(s) autor(es): | [1] Univ Fed Sao Paulo, Dept Psicobiol, Escola Paulista Med, Sao Paulo - Brazil
Número total de Afiliações: 1
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| Tipo de documento: | Artigo de Revisão |
| Fonte: | ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH; v. 46, n. 1 NOV 2021. |
| Citações Web of Science: | 0 |
| Resumo | |
Standard laboratory diets used have similar concentrations of proteins, carbohydrates and fat, but the concentration of some micronutrients can vary considerably. For example, the concentration of isoflavones can vary between 20 mg and 600 mg per gram of diet. Exposure to different concentrations of isoflavones interacts with alcohol (EtOH) intake, thereby influencing the results of alcohol research. In this mini-review, we describe correlations between isoflavone concentrations and alcohol intake based on data from previously published work. Although the administration of low doses of isoflavones can decrease alcohol intake in rats, there is a positive correlation between the isoflavone content in diets and alcohol intake in mice. This interaction seems to depend on the dose, route of administration, and time of exposure to isoflavones and may be related to specific neurobiological mechanisms. The literature also indicates that isoflavones can interact with some of alcohol's molecular targets and with neural pathways crucial to the alcohol reward process. Given these findings, more attention should be given to the different types of laboratory diets used in alcohol studies to allow better comparison and replication of animal research. (AU) | |
| Processo FAPESP: | 19/01686-0 - Depois do primeiro ‘drink’, não consigo parar! O efeito do álcool nos sistemas cerebrais de controle inibitório |
| Beneficiário: | Karina Possa Abrahão |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 19/24650-0 - Estudo da interação do consumo de alimento e de álcool |
| Beneficiário: | Paula Mendonça Camargo Eduardo |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |