| Full text | |
| Author(s): |
Total Authors: 2
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| Affiliation: | [1] Univ Fed Sao Paulo, Dept Psicobiol, Escola Paulista Med, Sao Paulo - Brazil
Total Affiliations: 1
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| Document type: | Review article |
| Source: | ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH; v. 46, n. 1 NOV 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Standard laboratory diets used have similar concentrations of proteins, carbohydrates and fat, but the concentration of some micronutrients can vary considerably. For example, the concentration of isoflavones can vary between 20 mg and 600 mg per gram of diet. Exposure to different concentrations of isoflavones interacts with alcohol (EtOH) intake, thereby influencing the results of alcohol research. In this mini-review, we describe correlations between isoflavone concentrations and alcohol intake based on data from previously published work. Although the administration of low doses of isoflavones can decrease alcohol intake in rats, there is a positive correlation between the isoflavone content in diets and alcohol intake in mice. This interaction seems to depend on the dose, route of administration, and time of exposure to isoflavones and may be related to specific neurobiological mechanisms. The literature also indicates that isoflavones can interact with some of alcohol's molecular targets and with neural pathways crucial to the alcohol reward process. Given these findings, more attention should be given to the different types of laboratory diets used in alcohol studies to allow better comparison and replication of animal research. (AU) | |
| FAPESP's process: | 19/01686-0 - I cannot stop after the first ‘drink’! Alcohol effects on the inhibitory control brain systems |
| Grantee: | Karina Possa Abrahão |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 19/24650-0 - Study about the interaction of food and alcohol consumption |
| Grantee: | Paula Mendonça Camargo Eduardo |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |