In vitro antiglycation and antioxidant properties of Eugenia pyriformis leaves and fruits

Autor(es)

da Silva, Giselle Lopes ^[1] ; Campideli, Mariana Bordin ^[2] ; Sabino Ferrari, Anna Beatriz ^[1] ; Mannochio-Russo, Helena ^[2] ; Fraige, Karina ^[2] ; Dametto, Alessandra Cristina ^[3] ; Bolzani, Vanderlan da Silva ^[2] ; Zeraik, Maria Luiza ^[1]

Afiliação do(s) autor(es)

^[1] State Univ Londrina UEL, Dept Chem, Lab Phytochem & Biomol LabFitoBio, Londrina, Parana - Brazil

^[2] Sao Paulo State Univ UNESP, Inst Chem, Dept Biochem & Organ Chem, Nuclei Bioassays Biosynth & Ecophysiol Nat Prod N, Araraquara, SP - Brazil

^[3] BioSmart Nanotechnol LTDA Me, Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NATURAL PRODUCT RESEARCH; NOV 2021.
• Citações Web of Science: 0

Resumo

Eight phenolic compounds were isolated from Eugenia pyriformis leaves fraction by semi-preparative HPLC and characterized by Nuclear Magnetic Resonance (NMR) and mass spectrometry (ESI-MS). Five compounds were isolated and identified for the first time in E. pyriformis species, while this is the first report of the accumulation of isoquercitrin, quercitrin, and the aglycone quercetin in its leaves. E. pyriformis leaves and fruits extracts, as well as the compounds isolated from the leaves most active fraction, were evaluated for their antiglycation and antioxidant activities. The mixture of myricetin-3-O-(2 `'-O-galloyl)-alpha-L-rhamnoside and myricetin-3-O-(4 `'-O-galloyl)-alpha-L-rhamnoside showed the highest antiglycation activity. These results suggest that this species is a promising source of bioactive compounds. Further studies to investigate the inhibition of the glycation process in vivo are necessary to evaluate its use in the treatment and/or prevention of advanced glycation end-products (AGEs)-associated diseases. (AU)

• Processo FAPESP: 13/07600-3 - CIBFar - Centro de Inovação em Biodiversidade e Fármacos
• Beneficiário: Glaucius Oliva
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 14/50926-0 - INCT 2014: biodiversidade e produtos naturais
• Beneficiário: Vanderlan da Silva Bolzani
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático