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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital Thais

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Autor(es):
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Fink, Thais T. [1] ; Marques, Heloisa H. S. [1] ; Gualano, Bruno [1] ; Lindoso, Livia [1] ; Bain, Vera [1] ; Astley, Camilla [1] ; Martins, Fernanda [1] ; Matheus, Denise [1] ; Matsuo, Olivia M. [1] ; Suguita, Priscila [1] ; Trindade, Vitor [1] ; Paula, Camila S. Y. [1] ; Farhat, Sylvia C. L. [1] ; Palmeira, Patricia [1] ; Leal, Gabriela N. [1] ; Suzuki, Lisa [1] ; Odone Filho, Vicente [1] ; Carneiro-Sampaio, Magda [1] ; Duarte, Alberto Jose S. [1] ; Antonangelo, Leila [1] ; Batisttella, Linamara R. [1] ; Polanczyk, V, Guilherme ; Pereira, Rosa Maria R. [2] ; Carvalho, Carlos Roberto R. [2] ; Buchpiguel, Carlos A. [2] ; Xavier, Ana Claudia L. [2] ; Seelaender, Marilia [2] ; Silva, Clovis Artur [2] ; Pereira, Maria Fernanda B. [2] ; Stud, HC-FMUSP Pediat Post-COVID-19
Número total de Autores: 30
Afiliação do(s) autor(es):
[1] Hosp Clin HCFMUSP, Fac Med, Sao Paulo, SP - Brazil
[2] Polanczyk, Guilherme, V, Hosp Clin HCFMUSP, Fac Med, Sao Paulo, SP - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: Clinics; v. 76, 2021.
Citações Web of Science: 1
Resumo

OBJECTIVES: To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19) METHODS: This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) and pediatric subjects without laboratory-confirmed COVID-19 included as controls (n=52) was performed. RESULTS: The median duration between COVID-19 diagnosis (n=53) and follow-up was 4.4 months (0.8-10.7). Twenty-three of 53 (43%) patients reported at least one persistent symptom at the longitudinal follow-up visit and 12/53 (23%) had long COVID-19, with at least one symptom lasting for >12 weeks. The most frequently reported symptoms at the longitudinal follow-up visit were headache (19%), severe recurrent headache (9%), tiredness (9%), dyspnea (8%), and concentration difficulty (4%). At the longitudinal follow-up visit, the frequencies of anemia (11% versus 0%, p=0.030), lymphopenia (42% versus 18%, p=0.020), C-reactive protein level of >30 mg/L (35% versus 0%, p=0.0001), and D-dimer level of >1000 ng/mL (43% versus 6%, p=0.0004) significantly reduced compared with baseline values. Chest X-ray abnormalities (11% versus 2%, p=0.178) and cardiac alterations on echocardiogram (33% versus 22%, p=0.462) were similar at both visits. Comparison of characteristic data between patients with COVID-19 at the longitudinal follow-up visit and controls showed similar age (p=0.962), proportion of male sex (p=0.907), ethnicity (p=0.566), family minimum monthly wage (p=0.664), body mass index (p=0.601), and pediatric pre-existing chronic conditions (p=1.000). The Pediatric Quality of Live Inventory 4.0 scores, median physical score (69 {[}0-100] versus 81 {[}34-100], p=0.012), and school score (60 {[}15-100] versus 70 {[}15-95], p=0.028) were significantly lower in pediatric patients with COVID-19 at the longitudinal follow-up visit than in controls. CONCLUSIONS: Pediatric patients with COVID-19 showed a longitudinal impact on HRQoL parameters, particularly in physical/school domains, reinforcing the need for a prospective multidisciplinary approach for these patients. These data highlight the importance of closer monitoring of children and adolescents by the clinical team after COVID-19. (AU)

Processo FAPESP: 15/03756-4 - Avaliação da relevância dos níveis sanguíneos de drogas utilizadas em doenças autoimunes reumatológicas no acompanhamento da segurança, eficácia e aderência à terapêutica
Beneficiário:Eloisa Silva Dutra de Oliveira Bonfá
Modalidade de apoio: Auxílio à Pesquisa - Temático