Metabolomic Evaluation of Chronic Periodontal Disease in Older Adults

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Rodrigues, Wellington F. ^{[1, 2]} ; Miguel, Camila B. ^{[2, 3]} ; Agostinho, Ferdinando ^[4] ; da Silva, V, Gabriela ; Lazo-Chica, Javier E. ^[5] ; Scapin, Sandra M. Naressi ^[6] ; Napimoga, Marcelo H. ^[7] ; Trindade-da-Silva, Carlos A. ^[1] ; Krieger, Jose E. ^[8] ; Pereira, Alexandre da Costa ^[8] ; Oliveira, Carlo J. Freire ^{[2, 4, 5]} ; Soares, Siomar de Castro ^{[4, 5]} ; Ueira-Vieira, Carlos ^[1] ; Kleinjan, Alex

Afiliação do(s) autor(es)

^[1] Univ Fed Uberlandia, Inst Genet & Biochem, BR-38400902 Uberlandia, MG - Brazil

^[2] Univ Fed Triangulo Mineiro, Postgrad Course Hlth Sci, BR-38015050 Uberaba, MG - Brazil

^[3] Univ Ctr Mineiros Unifimes, Med Course, BR-75830000 Mineiros, Go - Brazil

^[4] Univ Fed Triangulo Mineiro, Postgrad Course Physiol Sci, BR-38015050 Uberaba, MG - Brazil

^[5] Univ Fed Triangulo Mineiro, Inst Biol & Nat Sci, Cell Biol Lab, BR-38015050 Uberaba, MG - Brazil

^[6] Inst Nacl Metrol Qualidade & Tecnol, BR-25250020 Duque De Caxias, RJ - Brazil

^[7] Sao Leopoldo Mandic Fac SLMANDIC, Inst & Res Ctr Sao Leopoldo Mandic, BR-13045755 Campinas, SP - Brazil

^[8] da Silva, Gabriela, V, Univ Sao Paulo, Fac Med, Heart Inst INCOR, BR-05403900 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Mediators of Inflammation; v. 2021, NOV 18 2021.
• Citações Web of Science: 0

Resumo

Periodontal disease is an infectious inflammatory disease related to the destruction of supporting tissues of the teeth, leading to a functional loss of the teeth. Inflammatory molecules present in the exudate are catalyzed and form different metabolites that can be identified and quantified. Thus, we evaluated the inflammatory exudate present in crevicular fluid to identify metabolic biological markers for diagnosing chronic periodontal disease in older adults. Research participants were selected from long-term institutions in Brazil. Participants were individuals aged 65 years or older, healthy, or with chronic periodontal disease. Gas chromatography/mass spectrometry was used to evaluate potential biomarkers in 120 crevicular fluid samples. We identified 969 metabolites in the individuals. Of these, 15 metabolites showed a variable importance with projection score>1 and were associated with periodontal disease. Further analysis showed that among the 15 metabolites, two (5-aminovaleric acid and serine, 3TMS derivative) were found at higher concentrations in the crevicular fluid, indicating their potential diagnostic power for periodontal disease in older adults. Our findings indicated that some metabolites are present at high concentrations in the crevicular fluid in older adults with periodontal disease and can be used as biomarkers of periodontal disease. (AU)

• Processo FAPESP: 14/50889-7 - INCT 2014: em Medicina Assistida por Computação Científica (INCT-MACC)
• Beneficiário: José Eduardo Krieger
• Modalidade de apoio: Auxílio à Pesquisa - Temático