Nanoparticle Systems for Cancer Phototherapy: An Overview

Autor(es)

Pivetta, Thais P. ^{[1, 2]} ; Botteon, Caroline E. A. ^[3] ; Ribeiro, Paulo A. ^[2] ; Marcato, Priscyla D. ^[3] ; Raposo, Maria ^[2]

Afiliação do(s) autor(es)

^[1] Univ Nova Lisboa, NOVA Sch Sci & Technol, Dept Phys, CEFITEC, P-2829516 Caparica - Portugal

^[2] Univ Nova Lisboa, NOVA Sch Sci & Technol, Dept Phys, Lab Instrumentat Biomed Engn & Radiat Phys LIBPhy, P-2829516 Caparica - Portugal

^[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, GNanoBio, BR-14040900 Ribeirao Preto - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: NANOMATERIALS; v. 11, n. 11 NOV 2021.
• Citações Web of Science: 0

Resumo

Photodynamic therapy (PDT) and photothermal therapy (PTT) are photo-mediated treatments with different mechanisms of action that can be addressed for cancer treatment. Both phototherapies are highly successful and barely or non-invasive types of treatment that have gained attention in the past few years. The death of cancer cells because of the application of these therapies is caused by the formation of reactive oxygen species, that leads to oxidative stress for the case of photodynamic therapy and the generation of heat for the case of photothermal therapies. The advancement of nanotechnology allowed significant benefit to these therapies using nanoparticles, allowing both tuning of the process and an increase of effectiveness. The encapsulation of drugs, development of the most different organic and inorganic nanoparticles as well as the possibility of surfaces' functionalization are some strategies used to combine phototherapy and nanotechnology, with the aim of an effective treatment with minimal side effects. This article presents an overview on the use of nanostructures in association with phototherapy, in the view of cancer treatment. (AU)

• Processo FAPESP: 17/04138-8 - Realização de estudos químicos, analíticos, biológicos, farmacológicos e tecnológicos para preenchimento das lacunas no desenvolvimento do setor de própolis brasileiro
• Beneficiário: Jairo Kenupp Bastos
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/13465-5 - Desenvolvimento de nanopartículas poliméricas contendo própolis vermelha brasileira e avaliação antitumoral in vitro e in vivo em cânceres urológicos
• Beneficiário: Priscyla Daniely Marcato Gaspari
• Modalidade de apoio: Auxílio à Pesquisa - Regular