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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nanoparticle Systems for Cancer Phototherapy: An Overview

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Author(s):
Pivetta, Thais P. [1, 2] ; Botteon, Caroline E. A. [3] ; Ribeiro, Paulo A. [2] ; Marcato, Priscyla D. [3] ; Raposo, Maria [2]
Total Authors: 5
Affiliation:
[1] Univ Nova Lisboa, NOVA Sch Sci & Technol, Dept Phys, CEFITEC, P-2829516 Caparica - Portugal
[2] Univ Nova Lisboa, NOVA Sch Sci & Technol, Dept Phys, Lab Instrumentat Biomed Engn & Radiat Phys LIBPhy, P-2829516 Caparica - Portugal
[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, GNanoBio, BR-14040900 Ribeirao Preto - Brazil
Total Affiliations: 3
Document type: Review article
Source: NANOMATERIALS; v. 11, n. 11 NOV 2021.
Web of Science Citations: 0
Abstract

Photodynamic therapy (PDT) and photothermal therapy (PTT) are photo-mediated treatments with different mechanisms of action that can be addressed for cancer treatment. Both phototherapies are highly successful and barely or non-invasive types of treatment that have gained attention in the past few years. The death of cancer cells because of the application of these therapies is caused by the formation of reactive oxygen species, that leads to oxidative stress for the case of photodynamic therapy and the generation of heat for the case of photothermal therapies. The advancement of nanotechnology allowed significant benefit to these therapies using nanoparticles, allowing both tuning of the process and an increase of effectiveness. The encapsulation of drugs, development of the most different organic and inorganic nanoparticles as well as the possibility of surfaces' functionalization are some strategies used to combine phototherapy and nanotechnology, with the aim of an effective treatment with minimal side effects. This article presents an overview on the use of nanostructures in association with phototherapy, in the view of cancer treatment. (AU)

FAPESP's process: 17/04138-8 - Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps on the development of Brazilian propolis sector
Grantee:Jairo Kenupp Bastos
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 18/13465-5 - Development of polymeric nanoparticles with Brazilian red propolis and in vitro and in vivo evaluation of antitumor effect in urological cancers
Grantee:Priscyla Daniely Marcato Gaspari
Support Opportunities: Regular Research Grants