Effects of an interdisciplinary weight loss program on fibroblast growth factor 21 and inflammatory biomarkers in women with overweight and obesity

Autor(es)

Damaso, Ana Raimunda ^[1] ; Machado, Paola Prospero ^[1] ; Rhein, Samantha Ottani ^[1] ; Landi Masquio, Deborah Cristina ^[2] ; Oyama, Lila Missae ^{[3, 1]} ; Boldarine, Valter Tadeu ^{[3, 1]} ; de Oliveira, Gabriela Iervolino ^[4] ; Tock, Lian ^[4] ; Thivel, David ^{[5, 6]} ; da Silveira Campos, Raquel Munhoz ^{[7, 8]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Escola Paulista Med, Programa Posgrad Nutr, Sao Paulo, SP - Brazil

^[2] Ctr Univ Sao Camilo, Sao Paulo, SP - Brazil

^[3] Univ Fed Sao Paulo, Dept Fisiol, Escola Paulista Med, Sao Paulo, SP - Brazil

^[4] Escola Paulista Med, Grp Estudos Obesidade GEO UNIFESP, Sao Paulo, SP - Brazil

^[5] Clermont Auvergne Univ, EA 3533, Lab Metab Adaptat Exercise Physiol & Pathol Condi, Clermont Ferrand - France

^[6] CRNH Auvergne, Clermont Ferrand - France

^[7] Univ Fed Sao Paulo, Dept Biociencias, Campus Baixada Santista, Santos, SP - Brazil

^[8] Univ Fed Sao Paulo, Programa Posgrad Interdisciplinar Ciencias Saude, Campus Baixada Santista, Santos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF ENDOCRINOLOGY METABOLISM; v. 65, n. 6, p. 821-831, NOV-DEC 2021.
• Citações Web of Science: 0

Resumo

ABSTRACT Objective: To investigate the effects of an interdisciplinary intervention on biomarkers of inflammation and their relationship with fibroblast growth factor 21 (FGF21) concentrations in women with overweight and obesity. Subjects and methods: Thirty-one women were enrolled in a 12-week interdisciplinary weight loss program delivered by a team comprising an endocrinologist, nutritionist and exercise physiologist. Body composition; anthropometric measures; metabolic and inflammatory markers including adiponectin, leptin, and atrial natriuretic peptide (ANP) were assessed at baseline and post-therapy. The homeostasis model assessment of insulin resistance (HOMA-IR) and the homeostasis model assessment of adiponectin (HOMA-AD) were calculated. The participants were divided into two groups: those with increased FGF21, and those with decreased FGF21. Results: The sample comprised women aged 32 ± 5 years with a body mass index of 33.64 ± 3.49 kg/m2. Body weight, waist circumference and leptin concentration were decreased in the whole sample after therapy. However, only the group with an increase in FGF21 concentration presented significant improvements in adiponectin concentration and adiponectin/leptin ratio. Moreover, although there was a reduction of leptin in both groups, it was greater in the increased FGF21 groups. There was a reduction in ANP in the decreased FGF21 group. Conclusions: Changes in FGF21 concentrations were different among the women participating in the weight loss program, with some having increased levels and some reduced levels. Furthermore, improvements in adiponectin and the adiponectin/leptin ratio were found only in the group with increased FGF21 concentration. (AU)

• Processo FAPESP: 15/14309-9 - Efeitos do Exercício Físico associado à Fototerapia sobre os Marcadores da Adipogênese e Transdiferenciação do Tecido Adiposo em Mulheres Adultas com Obesidade
• Beneficiário: Raquel Munhoz da Silveira Campos
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/07372-1 - Novas fronteiras no combate à obesidade: educação em saúde digital como coadjuvante no processo clínico interdisciplinar
• Beneficiário: Ana Raimunda Dâmaso
• Modalidade de apoio: Auxílio à Pesquisa - Regular