Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of an interdisciplinary weight loss program on fibroblast growth factor 21 and inflammatory biomarkers in women with overweight and obesity

Full text
Author(s):
Damaso, Ana Raimunda [1] ; Machado, Paola Prospero [1] ; Rhein, Samantha Ottani [1] ; Landi Masquio, Deborah Cristina [2] ; Oyama, Lila Missae [3, 1] ; Boldarine, Valter Tadeu [3, 1] ; de Oliveira, Gabriela Iervolino [4] ; Tock, Lian [4] ; Thivel, David [5, 6] ; da Silveira Campos, Raquel Munhoz [7, 8]
Total Authors: 10
Affiliation:
[1] Univ Fed Sao Paulo, Escola Paulista Med, Programa Posgrad Nutr, Sao Paulo, SP - Brazil
[2] Ctr Univ Sao Camilo, Sao Paulo, SP - Brazil
[3] Univ Fed Sao Paulo, Dept Fisiol, Escola Paulista Med, Sao Paulo, SP - Brazil
[4] Escola Paulista Med, Grp Estudos Obesidade GEO UNIFESP, Sao Paulo, SP - Brazil
[5] Clermont Auvergne Univ, EA 3533, Lab Metab Adaptat Exercise Physiol & Pathol Condi, Clermont Ferrand - France
[6] CRNH Auvergne, Clermont Ferrand - France
[7] Univ Fed Sao Paulo, Dept Biociencias, Campus Baixada Santista, Santos, SP - Brazil
[8] Univ Fed Sao Paulo, Programa Posgrad Interdisciplinar Ciencias Saude, Campus Baixada Santista, Santos, SP - Brazil
Total Affiliations: 8
Document type: Journal article
Source: ARCHIVES OF ENDOCRINOLOGY METABOLISM; v. 65, n. 6, p. 821-831, NOV-DEC 2021.
Web of Science Citations: 0
Abstract

ABSTRACT Objective: To investigate the effects of an interdisciplinary intervention on biomarkers of inflammation and their relationship with fibroblast growth factor 21 (FGF21) concentrations in women with overweight and obesity. Subjects and methods: Thirty-one women were enrolled in a 12-week interdisciplinary weight loss program delivered by a team comprising an endocrinologist, nutritionist and exercise physiologist. Body composition; anthropometric measures; metabolic and inflammatory markers including adiponectin, leptin, and atrial natriuretic peptide (ANP) were assessed at baseline and post-therapy. The homeostasis model assessment of insulin resistance (HOMA-IR) and the homeostasis model assessment of adiponectin (HOMA-AD) were calculated. The participants were divided into two groups: those with increased FGF21, and those with decreased FGF21. Results: The sample comprised women aged 32 ± 5 years with a body mass index of 33.64 ± 3.49 kg/m2. Body weight, waist circumference and leptin concentration were decreased in the whole sample after therapy. However, only the group with an increase in FGF21 concentration presented significant improvements in adiponectin concentration and adiponectin/leptin ratio. Moreover, although there was a reduction of leptin in both groups, it was greater in the increased FGF21 groups. There was a reduction in ANP in the decreased FGF21 group. Conclusions: Changes in FGF21 concentrations were different among the women participating in the weight loss program, with some having increased levels and some reduced levels. Furthermore, improvements in adiponectin and the adiponectin/leptin ratio were found only in the group with increased FGF21 concentration. (AU)

FAPESP's process: 15/14309-9 - Effects of Physical Exercise associate with Phototherapy on Adipogenesis Biomarkers and Transdifferentiation of Adipose Tissue in Adult Obese Women
Grantee:Raquel Munhoz da Silveira Campos
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 17/07372-1 - New frontiers in the fight against obesity: digital health education as supporting in the interdisciplinary clinical process
Grantee:Ana Raimunda Dâmaso
Support Opportunities: Regular Research Grants