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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Tooth movement, orofacial pain, and leptin, interleukin-1 beta, and tumor necrosis factor-alpha levels in obese adolescents

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Autor(es):
Soares Bonato, Rafaela Carolina [1] ; Abel Mapengo, Marta Artemisa [1] ; De Azevedo-Silva, Lucas Jose [2] ; Janson, Guilherme [3] ; De Carvalho Sales-Peres, Silvia Helena [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Bauru Sch Dent, Dept Pediat Dent Orthodont & Publ Hlth, Alameda Octavio Pinheiro Brisolla 9-75, BR-17012901 Bauru, SP - Brazil
[2] Univ Sao Paulo, Bauru Sch Dent, Dept Prosthodont & Periodontol, Bauru, SP - Brazil
[3] Univ Sao Paulo, Bauru Sch Dent, Dept Orthodont, Bauru, SP - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: ANGLE ORTHODONTIST; v. 92, n. 1, p. 95-100, JAN 2022.
Citações Web of Science: 1
Resumo

Objectives: To evaluate tooth movement, orofacial pain, and leptin, interleukin (IL)-1 beta, and tumor necrosis factor (TNF)-alpha cytokine levels in the gingival crevicular fluid (GCF) during orthodontic treatment in obese adolescents. Materials and Methods: Participants included adolescent patients aged 12-18 years: group 1, obese (n=30), and group 2, nonobese controls (n=30). They were evaluated before (T-0) and after 1 hour (T-1), 24 hours (T-2), and 1 week (T-3) of fixed appliance bonding. Periodontal examination (T-0), collection of GCF (T-1,T- T-2,T- T-3), and evaluation of Little's irregularity index (T-0, T-3) were performed, and a visual analog scale was used to measure pain (T-1,T- T-2,T- T-3). Evaluation of IL-1 beta, TNF-alpha, and leptin cytokines was performed using a Luminex assay. Mann-Whitney and t-tests were used for intergroup comparisons, and a generalized estimating equation and cluster analyses were used for comparisons among observation times (P < .05). Results: The obese group had a higher prevalence of probing depth of >= 4 mm and bleeding on probing. Orthodontic tooth movement was similar in both groups. Peak of pain was at T-2 in both groups and was higher in the obese patients. TNF-alpha showed a slight increase at T-1, followed by a gradual decrease at T-2 and T-3 in both groups. The obese group had a higher concentration of IL-1 beta before and during orthodontic treatment. There was no difference in tooth movement between obese and control patients during the first week of orthodontic treatment. Conclusions: Obese adolescents had a greater subjective report of orofacial pain after 24 hours of orthodontic treatment and higher concentrations of IL-1 beta proinflammatory cytokine before and during tooth movement as compared with nonobese control adolescents. (AU)

Processo FAPESP: 18/25934-0 - Avaliação das proteínas diferencialmente expressas na saliva associadas à periodontite em gestantes obesas e eutróficas no pré e pós-termo
Beneficiário:Silvia Helena de Carvalho Sales Peres
Modalidade de apoio: Auxílio à Pesquisa - Regular