Tooth movement, orofacial pain, and leptin, interleukin-1 beta, and tumor necrosis factor-alpha levels in obese adolescents

Author(s)

Soares Bonato, Rafaela Carolina ^[1] ; Abel Mapengo, Marta Artemisa ^[1] ; De Azevedo-Silva, Lucas Jose ^[2] ; Janson, Guilherme ^[3] ; De Carvalho Sales-Peres, Silvia Helena ^[1]

Affiliation

^[1] Univ Sao Paulo, Bauru Sch Dent, Dept Pediat Dent Orthodont & Publ Hlth, Alameda Octavio Pinheiro Brisolla 9-75, BR-17012901 Bauru, SP - Brazil

^[2] Univ Sao Paulo, Bauru Sch Dent, Dept Prosthodont & Periodontol, Bauru, SP - Brazil

^[3] Univ Sao Paulo, Bauru Sch Dent, Dept Orthodont, Bauru, SP - Brazil

• Document type: Journal article
• Source: ANGLE ORTHODONTIST; v. 92, n. 1, p. 95-100, JAN 2022.
• Web of Science Citations: 1

Abstract

Objectives: To evaluate tooth movement, orofacial pain, and leptin, interleukin (IL)-1 beta, and tumor necrosis factor (TNF)-alpha cytokine levels in the gingival crevicular fluid (GCF) during orthodontic treatment in obese adolescents. Materials and Methods: Participants included adolescent patients aged 12-18 years: group 1, obese (n=30), and group 2, nonobese controls (n=30). They were evaluated before (T-0) and after 1 hour (T-1), 24 hours (T-2), and 1 week (T-3) of fixed appliance bonding. Periodontal examination (T-0), collection of GCF (T-1,T- T-2,T- T-3), and evaluation of Little's irregularity index (T-0, T-3) were performed, and a visual analog scale was used to measure pain (T-1,T- T-2,T- T-3). Evaluation of IL-1 beta, TNF-alpha, and leptin cytokines was performed using a Luminex assay. Mann-Whitney and t-tests were used for intergroup comparisons, and a generalized estimating equation and cluster analyses were used for comparisons among observation times (P < .05). Results: The obese group had a higher prevalence of probing depth of >= 4 mm and bleeding on probing. Orthodontic tooth movement was similar in both groups. Peak of pain was at T-2 in both groups and was higher in the obese patients. TNF-alpha showed a slight increase at T-1, followed by a gradual decrease at T-2 and T-3 in both groups. The obese group had a higher concentration of IL-1 beta before and during orthodontic treatment. There was no difference in tooth movement between obese and control patients during the first week of orthodontic treatment. Conclusions: Obese adolescents had a greater subjective report of orofacial pain after 24 hours of orthodontic treatment and higher concentrations of IL-1 beta proinflammatory cytokine before and during tooth movement as compared with nonobese control adolescents. (AU)

• FAPESP's process: 18/25934-0 - Evaluation of proteins differentially expressed in saliva associated with periodontitis in obese and eutrophic pregnant women before and after labor
• Grantee: Silvia Helena de Carvalho Sales Peres
• Support Opportunities: Regular Research Grants