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Effects of basic periodontal therapy on clinical parameters and levels of adipocytokines in obese subjects with chronic periodontitis

Grant number: 11/14875-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2012
Effective date (End): February 28, 2014
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Poliana Mendes Duarte
Grantee:Tiago Eduardo Dias Gonçalves
Host Institution: Universidade de Guarulhos (UNG). Campus Guarulhos-Centro. Guarulhos , SP, Brazil


Currently, obesity has been considered a risk indicator for periodontal diseases. However, the biological mechanisms associated with this phenomenon were not totally elucidated, especially those related to inflammatory process. Therefore, the aim of this study will be to evaluate the effects of basic periodontal therapy on clinical parameters and levels of adipocytokines [adiponectin, leptin, resistin, tumor necrosis factor (TNF)-alpha and interleukin (IL)-6] in the gingival crevicular fluid and serum of obese subjects with chronic periodontitis, when compared to subjects with normal body mass index (BMI) and chronic periodontitis. Forty subjects with chronic periodontitis will be enrolled in this study: obese (test; n=20) and normal BMI (control; n=20). The subjects will be submitted to clinical examination and gingival fluid and serum sampling before and at 3 and 6 months after basic periodontal therapy (supragingival calculus removal, plaque control and scaling and root planing). Fluid and serum samples will be evaluated by the presence of adiponectin, leptin, resistin, TNF-alpha and IL-6 by enzyme linked immunosorbent assay. Intra-group comparisons (before and after treatment) will be performed by Friedman test or repeated measured ANOVA, according to data normality. Inter-group comparisons (control/test) within each time-point will be performed by Mann-Whitney test and t-test. The level of significance will be set at 5%.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DIAS GONCALVES, TIAGO EDUARDO; SANTOS ZIMMERMANN, GLAUCIA; CRISTINA FIGUEIREDO, LUCIENE; DE CARVALHO SOUZA, MONIQUE; FERREIRA DA CRUZ, DANIELE; FERREIRA BASTOS, MARTA; PEREIRA DA SILVA, HELIO DOYLE; MENDES DUARTE, POLIANA. Local and serum levels of adipokines in patients with obesity after periodontal therapy: one-year follow-up. Journal of Clinical Periodontology, v. 42, n. 5, p. 431-439, . (11/14875-3, 13/01072-5)
DIAS GONCALVES, TIAGO EDUARDO; FERES, MAGDA; ZIMMERMANN, GLAUCIA SANTOS; FAVERI, MARCELO; FIGUEIREDO, LUCIENE CRISTINA; BRAGA, PALOMA GRALHA; DUARTE, POLIANA MENDES. Effects of Scaling and Root Planing on Clinical Response and Serum Levels of Adipocytokines in Patients With Obesity and Chronic Periodontitis. Journal of Periodontology, v. 86, n. 1, p. 53-61, . (11/14875-3)

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