Air pollution influence on serum inflammatory interleukins: A prospective study in childhood-onset systemic lupus erythematous patients

Autor(es)

Lima Farhat, Sylvia Costa ^{[1, 2, 3]} ; Ejnisman, Carolina ^{[4, 1]} ; Ferreira Alves, Andressa Guariento ^[1] ; Giacomin Goulart, Maria Fernanda ^[1] ; de Faria Coimbra Lichtenfels, Ana Julia ^[2] ; Ferreira Braga, Alfesio Luis ^{[1, 2, 5]} ; Amador Pereira, Luiz Alberto ^{[1, 2]} ; Elias, Adriana Maluf ^{[6, 3]} ; Silva, Clovis A. ^{[7, 6, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Environm Epidemiol Study Grp, Lab Expt Air Pollut, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med FMUSP, Lab Expt Air Pollut, LIM05, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Pediat Dept, Sao Paulo - Brazil

^[4] Univ Santo Amaro, Sao Paulo - Brazil

^[5] Univ Catolica Santos, Collect Hlth Postgrad Program, Environm Exposure & Risk Assessment Grp, Santos, SP - Brazil

^[6] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Pediat Rheumatol Unit, Sao Paulo - Brazil

^[7] Univ Sao Paulo, Fac Med FMUSP, Div Rheumatol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Lupus; v. 30, n. 14 DEC 2021.
• Citações Web of Science: 0

Resumo

Objective To assess the effect of individual exposure, in real-time, to traffic-related pollutants on serum interleukin levels of childhood-onset lupus erythematous systemic (c-SLE) patients. Methods A longitudinal and observational design was conducted in 12 repeated measures of serum samples and clinical evaluations (totaling 108 measurements) of c-SLE patients over 30 consecutive months. Real-time, individual exposure to fine particles (PM2.5) and nitrogen dioxide (NO2) was measured with portable monitors. Generalized estimating equation was used to evaluate the association between exposure to PM2.5 and NO2 and the following serum cytokine levels on the 7 days preceding clinical assessment and serum collection: MCP1, IL-6, IL-8, IL-10, IL-17, IFN-alpha, and TNF-alpha. Disease activity and other risk factors were also controlled. Results An interquartile range (IQR) increase in PM2.5 daily concentration was significantly associated with increased levels of TNF-alpha on the third, fourth, and seventh day after exposure; IL-10 on the third and fourth day after exposure; IL-17 on the third and seventh day after exposure; and INF-alpha on the third day after exposure (p < 0.05). An IQR increase in 7-day moving average of PM2.5 was associated with a 6.2 pg/mL (95% CI: 0.5; 11.8; p = 0.04) increase in serum IFN-alpha level. An unexpected significant association was observed between an IQR increase in NO(2)7-day cumulative concentration and a decrease of 1.6 pg/mL (95% CI: -2.6; -0.7; p < 0.001) in serum IL-17. Conclusion Real-time exposure to PM2.5 prospectively associated with increased serum TNF-alpha, INF-alpha, IL-10, and IL-17 levels in c-SLE patients. (AU)

• Processo FAPESP: 13/21508-2 - Influência da poluição do ar, medida individualmente, sobre atividade do lúpus eritematoso sistêmico juvenil: avaliação de bio-marcadores inflamatórios em exalado do ar condensado
• Beneficiário: Sylvia Costa Lima Farhat
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/03756-4 - Avaliação da relevância dos níveis sanguíneos de drogas utilizadas em doenças autoimunes reumatológicas no acompanhamento da segurança, eficácia e aderência à terapêutica
• Beneficiário: Eloisa Silva Dutra de Oliveira Bonfá
• Modalidade de apoio: Auxílio à Pesquisa - Temático