Air pollution influence on serum inflammatory interleukins: A prospective study in childhood-onset systemic lupus erythematous patients

Author(s)

Lima Farhat, Sylvia Costa ^{[1, 2, 3]} ; Ejnisman, Carolina ^{[4, 1]} ; Ferreira Alves, Andressa Guariento ^[1] ; Giacomin Goulart, Maria Fernanda ^[1] ; de Faria Coimbra Lichtenfels, Ana Julia ^[2] ; Ferreira Braga, Alfesio Luis ^{[1, 2, 5]} ; Amador Pereira, Luiz Alberto ^{[1, 2]} ; Elias, Adriana Maluf ^{[6, 3]} ; Silva, Clovis A. ^{[7, 6, 3]}

Affiliation

^[1] Univ Sao Paulo, Fac Med, Environm Epidemiol Study Grp, Lab Expt Air Pollut, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med FMUSP, Lab Expt Air Pollut, LIM05, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Pediat Dept, Sao Paulo - Brazil

^[4] Univ Santo Amaro, Sao Paulo - Brazil

^[5] Univ Catolica Santos, Collect Hlth Postgrad Program, Environm Exposure & Risk Assessment Grp, Santos, SP - Brazil

^[6] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Pediat Rheumatol Unit, Sao Paulo - Brazil

^[7] Univ Sao Paulo, Fac Med FMUSP, Div Rheumatol, Sao Paulo - Brazil

• Document type: Journal article
• Source: Lupus; v. 30, n. 14 DEC 2021.
• Web of Science Citations: 0

Abstract

Objective To assess the effect of individual exposure, in real-time, to traffic-related pollutants on serum interleukin levels of childhood-onset lupus erythematous systemic (c-SLE) patients. Methods A longitudinal and observational design was conducted in 12 repeated measures of serum samples and clinical evaluations (totaling 108 measurements) of c-SLE patients over 30 consecutive months. Real-time, individual exposure to fine particles (PM2.5) and nitrogen dioxide (NO2) was measured with portable monitors. Generalized estimating equation was used to evaluate the association between exposure to PM2.5 and NO2 and the following serum cytokine levels on the 7 days preceding clinical assessment and serum collection: MCP1, IL-6, IL-8, IL-10, IL-17, IFN-alpha, and TNF-alpha. Disease activity and other risk factors were also controlled. Results An interquartile range (IQR) increase in PM2.5 daily concentration was significantly associated with increased levels of TNF-alpha on the third, fourth, and seventh day after exposure; IL-10 on the third and fourth day after exposure; IL-17 on the third and seventh day after exposure; and INF-alpha on the third day after exposure (p < 0.05). An IQR increase in 7-day moving average of PM2.5 was associated with a 6.2 pg/mL (95% CI: 0.5; 11.8; p = 0.04) increase in serum IFN-alpha level. An unexpected significant association was observed between an IQR increase in NO(2)7-day cumulative concentration and a decrease of 1.6 pg/mL (95% CI: -2.6; -0.7; p < 0.001) in serum IL-17. Conclusion Real-time exposure to PM2.5 prospectively associated with increased serum TNF-alpha, INF-alpha, IL-10, and IL-17 levels in c-SLE patients. (AU)

• FAPESP's process: 13/21508-2 - Influence of air pollution, measured individually, on disease activity in childhood-onset systemic lupus erythematosus patients through the evaluation of inflammatory biomarkers in exhaled condensed air
• Grantee: Sylvia Costa Lima Farhat
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/03756-4 - Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy
• Grantee: Eloisa Silva Dutra de Oliveira Bonfá
• Support Opportunities: Research Projects - Thematic Grants