Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy

• Grant number: 15/03756-4
• Support Opportunities: Research Projects - Thematic Grants
• Duration: March 01, 2017 - February 28, 2023
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Eloisa Silva Dutra de Oliveira Bonfá
• Grantee: Eloisa Silva Dutra de Oliveira Bonfá
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Pesquisadores principais: Clovis Artur Almeida da Silva ; Nádia Emi Aikawa ; Sandra Gofinet Pasoto
• Associated researchers: Alberto José da Silva Duarte ; Ana Cristina de Medeiros Ribeiro ; Carla Gonçalves Schahin Saad ; Eduardo Ferreira Borba Neto ; Esper Georges Kallás ; Gilberto de Nucci ; Luis Felipe das Chagas e Silva de Carvalho ; Pedro Carlos Carricondo ; Rosa Maria Rodrigues Pereira ; Valdemir Melechco Carvalho ; Vilma dos Santos Trindade Viana
• Associated grant(s): 17/03983-6 - Liquid chromatography coupled to mass spectrometry (2015/03756-4), AP.EMU
• Associated scholarship(s): 22/09565-0 - Post-Covid-19 syndrome in patients with autoimmune rheumatological diseases, BP.IC; 22/09566-6 - Immunogenicity and safety of booster doses of CoronaVac vaccine in patients with autoimmune rheumatologic diseases patients, BP.IC; 21/08455-3 - Immunogenicity and safety of Coronavac vaccine in patients with autoimmune rheumatologic diseases: primary Sjörgren syndrome, BP.IC; + associated scholarships 21/06613-0 - Immunogenicity and safety of CoronaVac vaccine in patients with autoimmune rheumatic diseases: rheumatoid arthritis, BP.IC; 21/06615-3 - Immunogenicity and safety of CoronaVac vaccine in patients with autoimmune rheumatologic diseases: Juvenile systemic erythemesus lupus, BP.IC; 21/06616-0 - Validation of dry sample devices (Dried Blood Spot) for the therapeutic monitoring of hydroxychloroquine in rheumatic diseases, BP.IC; 20/11677-5 - Analysis of the immune profile of saliva and serum of patients with primary Sjögren's Syndrome, BP.IC; 20/09367-8 - Analysis of blood hydroxychlorochine levels in patients with primary Sjogren Syndrome and possible correlation with the disease activity, BP.DD; 20/02625-1 - Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy, BP.TT; 19/21211-6 - Salivary hydroxychloroquine levels: relevance in juvenile systemic lupus erythematosus (JSLE) disease activity and renal disease activity in adult systemic lupus erythematosus, BP.IC; 19/21173-7 - Evaluation of the treatment of cutaneous lupus erythematosus with thalidomide: clinical, laboratory and histological factors associated with clinical response and adverse effects, BP.IC; 19/17272-0 - Relevance of monitoring blood levels compared to salivar levels of drugs used in rheumatic autoimmune diseases: adherence and understanding the possible underlying mechanisms involved in effectiveness and in adverse effects, BP.PD; 18/21594-0 - Analysis of the immune profile of saliva and serum of patients with primary Sjögren's syndrome, BP.IC; 18/09937-9 - Analysis of the immune profile of saliva and serum of patients with primary Sjogren's Syndrome, BP.DD; 17/14352-7 - Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy, BP.PD; 17/11516-9 - Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy, BP.PD; 17/11854-1 - Assessment of serum levels of anti-tumor necrosis factor (anti-TNF) and anti-drug antibodies (ADA) in patients with chronic inflammatory arthritis: ankylosing spondylitis and psoriatic arthritis, BP.IC; 17/11644-7 - Blood and salivary levels of hydroxychloroquine: relevance in juvenile systemic lupus erythematosus disease (JSLE), in kidney disease in adult SLE activity and in alpha-interferon / TNF production by plasmacytoid dendritic cells, BP.TT; 17/07964-6 - Evaluation of serum levels of anti-tumor necrosis factor (antiTNF) and anti-drug (ada) antibodies in patients with chronic inflammatory arthritis - juvenile idiopathic arthritis, BP.IC; 17/07966-9 - Assessment of serum levels of anti-tumor necrosis factor (anti-TNF) and anti-drug antibodies (ADA) in patients with chronic inflammatory arthritis: ankylosing spondylitis and psoriatic arthritis, BP.IC - associated scholarships

Abstract

No drug treatment is completely free of risk and lack of response, adverse events and poor adherence may affect its effectiveness. There is also a large inter-individual variability in response to treatments with regard to efficacy and toxicity, and for many drugs, there is also a period of weeks to months to establish its efficacy. Within this context, this project aims to evaluate the importance of monitoring blood levels and salivary drug used in rheumatic autoimmune diseases in the monitoring of adherence to therapy. In addition, this project intends to use the monitoring of drug levels, based on pharmacokinetic studies and pharmacokinetics/pharmacodynamics modeling, to broaden the understanding of the possible cellular, tissue and immunological mechanisms involved in efficacy and adverse effects of these drugs with the prospect of reducing the damage and maintain therapeutic efficacy. The high-performance liquid chromatography (HPLC) coupled to mass spectrometry, which will be used to evaluate hydroxychloroquine, thalidomide, glucocorticoids, is considered the gold standard technology to qualitative and quantitative analysis of drugs in blood and its comparison with the dosage in the saliva is an improvement in simplification of the process. The implementation of this methodology dedicated to research in our center, with the necessary training of human resources, will enable the standardization and availability of this advanced technology to other muldisciplinary projects in various areas of science. For biological agents the focus will be on the understanding the loss of efficacy and the possible role of anti-TNF antibodies using ELISA capture methodology.This thematic project will be divided into four sections with their respective sub-projects according to the medications that will be studied: hydroxychloroquine, thalidomide, biologic agents and glucocorticoids. (AU)

Scientific publications

(88)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CLOVIS ARTUR SILVA; VITOR CAVALCANTI TRINDADE; AMANDA MONTEIRO DA CRUZ; BRUNA PACCOLA BLANCO; JOÃO FERNANDO VECCHI SANTOS; ALEXANDRE ARCHANJO FERRARO; VICENTE ODONE-FILHO; UENIS TANNURI; WERTHER BRUNOW CARVALHO; MAGDA CARNEIRO-SAMPAIO; et al. Profile of health professionals who completed a master’s, doctoral, or post-doctoral degree in one Brazilian pediatric program. Clinics, v. 75, 2020-04-17. (15/03756-4)

BENATTI, FABIANA B.; MIYAKE, CINTIA N. H.; DANTAS, WAGNER S.; ZAMBELLI, VANESSA O.; SHINJO, SAMUEL K.; PEREIRA, ROSA M. R.; SILVA, MARIA ELIZABETH R.; SA-PINTO, ANA LUCIA; BORBA, EDUARDO; BONFA, ELOISA; et al. Exercise Increases Insulin Sensitivity and Skeletal Muscle AMPK Expression in Systemic Lupus Erythematosus: A Randomized Controlled Trial. FRONTIERS IN IMMUNOLOGY, v. 9, APR 27 2018. (11/08302-0, 15/03756-4, 11/24093-2, 17/02546-1)

PRADO, L. L.; GONCALVES, C. R.; VIANA, V. T.; SAAD, C. G. S.; BONFA, E.. Anti-alpha-enolase antibodies in Behcet's disease: a marker of mucocutaneous and articular disease activity?. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v. 36, n. 6, 115, p. S28-S32, 2018. (15/03756-4)

FERREIRA, V, GABRIELA R.; TOMIOKA, RENATO B.; QUEIROZ, LIGIA B.; KOZU, KATIA; AIKAWA, NADIA E.; SALLUM, ADRIANA M. E.; SERAFINI, PAULO; TACLA, MARICY; BARACAT, EDMUND C.; PEREIRA, ROSA M. R.; et al. Lower genital tract infections in young female juvenile idiopathic arthritis patients. ADVANCES IN RHEUMATOLOGY, v. 59, n. 1, NOV 15 2019. (15/03756-4, 14/14806-0)

BRUNELLI, JULIANA BARBOSA; SILVA, CLOVIS ALMEIDA; PASOTO, SANDRA GOFINET; SCHAHIN SAA, CARLA GONCALVES; KOZU, KATIA TOMIE; GOLDENSTEIN-SCHAINBERG, CLAUDIA; LEON, ELAINE PIRES; VENDRAMINI, MARGARETE B. G.; FONTOURA, NICOLE; BONFA, ELOISA; et al. Anti-adalimumab antibodies kinetics: an early guide for juvenile idiopathic arthritis (JIA) switching. CLINICAL RHEUMATOLOGY, NOV 2019. (15/03756-4)

SILVA, CLOVIS ARTUR; TRINDADE, VITOR CAVALCANTI; DA CRUZ, AMANDA MONTEIRO; BLANCO, BRUNA PACCOLA; VECCHI SANTOS, JOAO FERNANDO; FERRARO, ALEXANDRE ARCHANJO; ODONE-FILHO, VICENTE; TANNURI, UENIS; CARVALHO, WERTHER BRUNOW; CARNEIRO-SAMPAIO, MAGDA; et al. Profile of health professionals who completed a master's, doctoral, or post-doctoral degree in one Brazilian pediatric program. Clinics, v. 75, 2020. (15/03756-4)

DINIS, VALQUIRIA G.; VIANA, VILMA T.; LEON, ELAINE P.; SILVA, CLOVIS A.; SAAD, CARLA G.; MORAES, JULIO C.; BONFA, ELOISA S.; MEDEIROS-RIBEIRO, ANA C.. Abatacept induced long-term non-progressive reduction in gamma-globulins and autoantibodies: dissociation from disease activity control. CLINICAL RHEUMATOLOGY, v. 39, n. 6, p. 1747-1755, JUN 2020. (15/03756-4)

CAROLINE GOUVEIA BUFF PASSONE; SANDRA JOSEFINA GRISI; SYLVIA COSTA FARHAT; THAIS DELLA MANNA; ANTONIO CARLOS PASTORINO; RENATA ANTUNES ALVENO; CAROLINE VASCONCELOS SÁ MIRANDA; AURORA ROSARIA WAETGE; MARIANA NUTTI CORDON; VICENTE ODONE-FILHO; et al. COMPLEXIDADE DA DOENÇA CRÔNICA PEDIÁTRICA: ESTUDO TRANVERSAL COM 16.237 PACIENTES SEGUIDOS POR MÚLTIPLAS ESPECIALIDADES MÉDICAS. Revista Paulista de Pediatria, v. 38, 2019-11-25. (15/03756-4)

BALBI, VERENA A.; MONTENEGRO, BARBARA; PITTA, ANA C.; SCHMIDT, ANA R.; FARHAT, SYLVIA C.; COELHO, LAILA P.; FERREIRA, JULIANA C. O.; PEREIRA, ROSA M. R.; TERRERI, MARIA T.; SAAD-MAGALHAES, CLAUDIA; et al. Autoimmune hepatitis in 847 childhood- onset systemic lupus erythematosus population: a multicentric cohort study. ADVANCES IN RHEUMATOLOGY, v. 58, DEC 13 2018. (15/03756-4)

SHIMABUCO, ANDREA Y.; GONCALVES, CELIO R.; MORAES, JULIO C. B.; WAISBERG, MARIANA G.; RIBEIRO, ANA CRISTINA DE M.; SAMPAIO-BARROS, PERCIVAL D.; GOLDENSTEIN-SCHAINBERG, CLAUDIA; BONFA, ELOISA; SAAD, CARLA G. S.. Factors associated with ASDAS remission in a long-term study of ankylosing spondylitis patients under tumor necrosis factor inhibitors. ADVANCES IN RHEUMATOLOGY, v. 58, DEC 4 2018. (15/03756-4)

BUSCATTI, IZABEL M.; ABRAO, HENRIQUE M.; KOZU, KATIA; MARQUES, VICTOR L. S.; GOMES, ROBERTA C.; SALLUM, ADRIANA M. E.; SILVA, CLOVIS A.. Characterization of scrotal involvement in children and adolescents with IgA vasculitis. ADVANCES IN RHEUMATOLOGY, v. 58, NOV 3 2018. (15/03756-4)

SILVA, CLOVIS A.; TERRERI, MARIA T.; BONFA, ELOISA; SAAD-MAGALHAES, CLAUDIA. Pediatric rheumatic disease patients: time to extend the age limit of adolescence?. ADVANCES IN RHEUMATOLOGY, v. 58, SEP 18 2018. (15/03756-4)

FERREIRA, GABRIELA R. V.; TOMIOKA, RENATO B.; AIKAWA, NADIA E.; LEON, ELAINE P.; MACIEL, GUSTAVO A. R.; SERAFINI, PAULO C.; BARACAT, EDMUND C.; GOLDENSTEIN-SCHAINBERG, CLAUDIA; PEREIRA, ROSA M. R.; BONFA, ELOISA; et al. Ovarian reserve in young juvenile idiopathic arthritis patients. MODERN RHEUMATOLOGY, v. 29, n. 3, p. 447-451, MAY 4 2019. (15/03756-4, 14/14806-0)

BRUNNER, HERMINE I.; HOLLAND, MICHAEL; BERESFORD, MICHAEL W.; ARDOIN, STACY P.; APPENZELLER, SIMONE; SILVA, CLOVIS A.; FLORES, FRANCISCO; GOILAV, BEATRICE; WENDERFER, SCOTT E.; LEVY, DEBORAH M.; et al. American College of Rheumatology Provisional Criteria for Global Flares in Childhood-Onset Systemic Lupus Erythematosus. ARTHRITIS CARE & RESEARCH, v. 70, n. 6, p. 813-822, JUN 2018. (15/03756-4)

FIOROT, FERNANDA J.; ISLABAO, ALINE G.; PEREIRA, ROSA M.; TERRERI, MARIA T.; SAAD-MAGALHAES, CLAUDIA; NOVAK, V, GLAUCIA; MOLINARI, BEATRIZ C.; SAKAMOTO, ANA P.; AIKAWA, NADIA E.; CAMPOS, LUCIA M.; et al. Disease presentation of 1312 childhood-onset systemic lupus erythematosus: influence of ethnicity. CLINICAL RHEUMATOLOGY, v. 38, n. 10, p. 2857-2863, OCT 2019. (15/03756-4)

ISLABA, ALINE G.; MOTA, LICIA M. H.; RIBEIRO, MARIA CUSTODIA M.; ARABI, TAMIMA M.; CIVIDATTI, GEORGIANA N.; QUEIROZ, LIGIA B.; ANDRADE, DANIELI C.; SAKAMOTO, ANA P.; TRINDADE, VITOR C.; NOVAK, GLAUCIA V.; et al. Childhood-onset systemic lupus erythematosus-related antiphospholipid syndrome: A multicenter study with 1519 patients. AUTOIMMUNITY REVIEWS, v. 19, n. 12, DEC 2020. (15/03756-4)

FERREIRA, JULIANA C. O. A.; TRINDADE, VITOR C.; ESPADA, GRACIELA; MOREL, ZOILO; BONFA, ELOISA; MAGALHAES, CLAUDIA S.; SILVA, CLOVIS ARTUR. Epidemiology and management practices for childhood-onset systemic lupus erythematosus patients: a survey in Latin America. CLINICAL RHEUMATOLOGY, v. 37, n. 12, p. 3299-3307, DEC 2018. (15/03756-4)

ALVENO, RENATA A.; MIRANDA, V, CAROLINE; PASSONE, CAROLINE G.; WAETGE, AURORA R.; HOJO, ELZA S.; FARHAT, SYLVIA C. L.; ODONE-FILHO, VICENTE; TANNURI, UENIS; CARVALHO, WERTHER B.; CARNEIRO-SAMPAIO, MAGDA; et al. Pacientes pediátricos crônicos em clínicas ambulatoriais: estudo em um hospital universitário da América Latina. Jornal de Pediatria, v. 94, n. 5, p. 539-545, SEP-OCT 2018. (15/03756-4)

CLOVIS ARTUR SILVA. REDUÇÃO DA ADERÊNCIA AO TRATAMENTO MEDICAMENTOSO EM CRIANÇAS E ADOLESCENTES COM DOENÇAS REUMÁTICAS AUTOIMUNES. Revista Paulista de Pediatria, v. 37, n. 2, p. 138-139, 2019-06-19. (15/03756-4)

SIGNORELLI, FLAVIO; BALBI, GUSTAVO GUIMARAES MOREIRA; BONFA, ELOISA; BORBA, EDUARDO F.; ANDRADE, DANIELI CASTRO DE OLIVEIRA. Avoiding misclassification of thrombotic primary antiphospholipid syndrome as systemic lupus erythematosus (SLE): What are the best-performing SLE classification criteria?. Lupus, v. 30, n. 11, JUL 2021. (15/03756-4)

BALMANT, BIANCA D.; TORRINHAS, RAQUEL S.; ROCHA, ILANNA M.; FONSECA, DANIELLE C.; FORMIGA, FRANCISCO F. C.; BONFA, ELOISA S. D. O.; BORBA, EDUARDO F.; WAITZBERG, DAN L.. SARS-CoV-2 infection, gut dysbiosis, and heterogeneous clinical results of hydroxychloroquine on COVID-19 therapy & mdash;Is there a link?. NUTRITION, v. 85, MAY 2021. (18/16162-3, 15/03756-4)

REINAN TAVARES CAMPOS; LORENA VASCONCELOS MESQUITA MARTINIANO; AMANDA KERLYN SANTOS LIRIO; KALESA ELIAS DE ARAUJO SOUZA; NATALIA ROSE; JULIANA MARTINS MONTEIRO DIAS; ANTÔNIO CARLOS ALVES CARDOSO; SYLVIA COSTA FARHAT; CLOVIS ARTUR SILVA. Violência não sexual contra crianças e adolescentes: um estudo em um hospital universitário e terciário da América Latina. Revista Paulista de Pediatria, v. 40, 2022-05-02. (15/03756-4)

MARIANA MACHADO FORTI NASTRI; BENITO LOURENÇO; LIGIA BRUNI QUEIROZ; LUIZ EDUARDO VARGAS DA SILVA; DANIELA MENCARONI RODRIGUES LOURENÇO; ANA PAULA BELTRAN MOSCHIONE CASTRO; CLOVIS ARTUR SILVA; ANTONIO CARLOS PASTORINO. Idiopathic musculoskeletal pain, musculoskeletal pain syndromes, and use of electronic devices in adolescents with asthma. Jornal de Pediatria, v. 98, n. 3, p. 270-275, 2022-06-06. (15/03756-4)

PATRICIA MORENO GRANGEIRO; MOISÉS DE FREITAS LAURENTINO; FERNANDA GÉA DE LUCENA GOMES; DANIELA SIMONE ALVAREZ; CÉSAR AUGUSTO MOREIRA; NATÁLIA ANGÉLICA DE SOUZA; JENNIFER MACENA BALBINO; CANDIDO LEONELLI; RICARDO MARCONDES MACÉA; CLOVIS ARTUR ALMEIDA DA SILVA. TELEATENDIMENTO A CRIANÇAS E ADOLESCENTES COM DEFICIÊNCIAS FÍSICAS DURANTE A PANDEMIA COVID-19. Acta Ortopédica Brasileira, v. 30, 2022-07-06. (15/03756-4)

LIVIA LINDOSO; CAMILLA ASTLEY; LIGIA BRUNI QUEIROZ; BRUNO GUALANO; ROSA MARIA RODRIGUES PEREIRA; UENIS TANNURI; LÚCIA MARIA MATTEI DE ARRUDA CAMPOS; BENITO LOURENÇO; RICARDO KATSUYA TOMA; KARINA MEDEIROS; et al. Physical and mental health impacts during COVID-19 quarantine in adolescents with preexisting chronic immunocompromised conditions. Jornal de Pediatria, v. 98, n. 4, p. 350-361, 2022-07-25. (15/03756-4)

MOISÉS DE FREITAS LAURENTINO; LIVIA LINDOSO; CAMILLA ASTLEY; SOFIA SIMÃO MARTINS LAVORATO; BIANCA PIRES IHARA; DANDARA CARVALHO CASADO DE LIMA; BRUNO GUALANO; LÍGIA BRUNI QUEIROZ; ROSA MARIA RODRIGUES PEREIRA; GUILHERME VANONI POLANCZYK; et al. Impacto da COVID-19 no funcionamento físico e mental de adolescentes com deficiência em organização não governamental esportiva. Revista Paulista de Pediatria, v. 41, 2022-11-14. (15/03756-4)

ROSA M.R. PEREIRA; MARILIA A. DAGOSTIN; VALERIA F. CAPARBO; LUCAS P. SALES; SANDRA G. PASOTO; CLOVIS A. SILVA; EMILY F.N. YUKI; CARLA G.S. SAAD; ANA C. MEDEIROS-RIBEIRO; LEONARD V.K. KUPA; et al. Anti-SARS-CoV-2 inactivated vaccine in patients with ANCA-associated vasculitis: Immunogenicity, safety, antibody decay and the booster dose. Clinics, v. 78, 2023-02-27. (15/03756-4, 18/09937-9, 19/17272-0, 20/09367-8, 21/08455-3)

ANDREA YUKIE SHIMABUCO; ANA CRISTINA DE MEDEIROS-RIBEIRO; RENATA MIOSSI; KARINA ROSSI BONFIGLIOLI; JULIO CESAR BERTACINI DE MORAES; CELIO ROBERTO GONÇALVES; PERCIVAL DEGRAVA SAMPAIO-BARROS; CLAUDIA GOLDENSTEIN-SCHAINBERG; FERNANDO HENRIQUE CARLOS DE SOUZA; LEANDRO LARA DO PRADO; et al. Ankylosing spondylitis and psoriatic arthritis: revisiting screening of latent tuberculosis infection and its follow-up during anti-tumor necrosis factor therapy in an endemic area. Clinics, v. 75, 2020-11-11. (15/03756-4)

BRAIAN L.A. SOUSA; MAGDA SAMPAIO-CARNEIRO; WERTHER B. DE CARVALHO; CLOVIS A. SILVA; ALEXANDRE A. FERRARO. Differences among Severe Cases of Sars-CoV-2, Influenza, and Other Respiratory Viral Infections in Pediatric Patients: Symptoms, Outcomes and Preexisting Comorbidities. Clinics, v. 75, 2020-11-30. (15/03756-4, 14/50489-9)

USUBA, FANY SOLANGE; SCHAHIN SAAD, CARLA GONCALVES; AIKAWA, NADIA EMI; NOVAES, PRISCILA; BERTACINI MORAES, JULIO CESAR; SANTO, RUTH MIYUKI; CARVALHO, JOZELIO FREIRE; BONFA, ELOISA; ALVES, MILTON RUIZ. Improvement of conjunctival cytological grade and tear production in Ankylosing Spondylitis patients under TNF inhibitors: a long-term follow-up. SCIENTIFIC REPORTS, v. 10, n. 1, JAN 15 2020. (15/03756-4)

ASTLEY, CAMILLA; PINTO, ANA JESSICA; BONFA, ELOISA; DA SILVA, CLOVIS ARTUR ALMEIDA; GUALANO, BRUNO. Gaps on rheumatologists' knowledge of physical activity. CLINICAL RHEUMATOLOGY, v. 40, n. 7, JAN 2021. (15/26937-4, 17/13552-2, 15/03756-4)

ZANETTI, CAIO B.; PEDROSA, TATIANA; KUPA, LEONARD DE V. K.; AIKAWA, NADIA E.; BORBA, EDUARDO F.; VENDRAMINI, MARGARETE B. G.; SILVA, CLOVIS A.; PASOTO, SANDRA G.; BONFA, ELOISA. Hydroxychloroquine blood levels in stable lupus nephritis under low dose (2-3 mg/kg/day): 12-month prospective randomized controlled trial. CLINICAL RHEUMATOLOGY, v. 40, n. 7, JAN 2021. (17/14352-7, 19/17272-0, 15/03756-4, 17/03983-6)

USUBA, FANY SOLANGE; DE MEDEIROS-RIBEIRO, ANA CRISTINA; NOVAES, PRISCILA; AIKAWA, NADIA EMI; BONFIGLIOLI, KARINA; SANTO, RUTH MIYUKI; BONFA, ELOISA; ALVES, MILTON RUIZ. Dry eye in rheumatoid arthritis patients under TNF-inhibitors: conjunctival goblet cell as an early ocular biomarker. SCIENTIFIC REPORTS, v. 10, n. 1, AUG 20 2020. (15/03756-4)

PEDROSA, TATIANA N.; PASOTO, SANDRA G.; AIKAWA, NADIA E.; YUKI, EMILY F. N.; BORBA, EDUARDO F.; FERREIRA FILHO, JULIO C. R.; CARRICONDO, PEDRO C.; ZANETTI, CAIO B.; CONDE, PAOLA G.; DUARTE, NILO J. C.; et al. Understanding the dynamics of hydroxychloroquine blood levels in lupus nephritis. Lupus, v. 29, n. 6, MAR 2020. (15/03756-4, 17/11516-9, 17/11854-1, 17/14352-7, 17/11644-7)

MARCO AURELIO PALAZZI SAFADI; CLOVIS ARTUR ALMEIDA DA SILVA. O ESPECTRO DESAFIADOR E IMPREVISÍVEL DA COVID-19 EM CRIANÇAS E ADOLESCENTES. Revista Paulista de Pediatria, v. 39, 2020-09-07. (15/03756-4)

PEDROSA, TATIANA; KUPA, LEONARD DE VINCI KANDA; AIKAWA, NADIA EMI; PASOTO, SANDRA GOFINET; BONFA, ELOISA; SILVA, CLOVIS ARTUR. Lupus nephritis-related issues during COVID-19 pandemic quarantine. Lupus, v. 29, n. 14, SEP 2020. (17/14352-7, 19/17272-0, 15/03756-4, 17/03983-6)

HELITO, ALBERTO C.; LINDOSO, LIVIA; SIECZKOWSKA, SOFIA M.; ASTLEY, CAMILLA; QUEIROZ, LIGIA B.; ROSE, NATALIA; SANTOS, CLAUDIA RENATA P.; BOLZAN, THALIS; PERALTA, RITA MARIA I. A.; FRANCO, RUTH R.; et al. Poor Sleep quality and health-related quality of life impact in adolescents with and without chronic immunosuppressive conditions during COVID-19 quarantine. Clinics, v. 76, 2021. (15/03756-4)

ISLABAO, ALINE GARCIA; TRINDADE, VITOR CAVALCANTI; DA MOTA, LICIA MARIA HENRIQUE; ANDRADE, DANIELI CASTRO OLIVEIRA; SILVA, CLOVIS ARTUR. Managing Antiphospholipid Syndrome in Children and Adolescents: Current and Future Prospects. PEDIATRIC DRUGS, v. 24, n. 1, DEC 2021. (15/03756-4)

ASTLEY, CAMILLA; CLEMENTE, GLEICE; TERRERI, MARIA TERESA; CARNEIRO, CAMILA G.; LIMA, MARCOS S.; BUCHPIGUEL, CARLOS ALBERTO; LEAO FILHO, HILTON; PINTO, ANA LUCIA DE SA; SILVA, CLOVIS ARTUR; ARRUDA CAMPOS, LUCIA MARIA; et al. Home-Based Exercise Training in Childhood-Onset Takayasu Arteritis: A Multicenter, Randomized, Controlled Trial. FRONTIERS IN IMMUNOLOGY, v. 12, JUL 28 2021. (15/03756-4, 17/07358-9, 17/13552-2)

CHALHOUB, NATHALIE E.; WENDERFER, SCOTT E.; LEVY, DEBORAH M.; ROUSTER-STEVENS, KELLY; AGGARWAL, AMITA; SAVANI, I, SONIA; RUTH, NATASHA M.; ARKACHAISRI, THASCHAWEE; QIU, TINGTING; MERRITT, ANGELA; et al. nternational Consensus for the Dosing of Corticosteroids in Childhood-Onset Systemic Lupus Erythematosus With Proliferative Lupus Nephriti. ARTHRITIS & RHEUMATOLOGY, v. 74, n. 2, JAN 2022. (15/03756-4)

BALBI, VERENA ANDRADE; SILVA, CLOVIS ARTUR; PEDROSA, TATIANA NASCIMENTO; RODRIGUES PEREIRA, ROSA MARIA; DE ARRUDA CAMPOS, LUCIA MARIA; LEON, ELAINE PIRES; DUARTE, NILO; CARVALHO, VALDEMIR MELECHCO; PASOTO, SANDRA GOFINT; DO ROSARIO, DEBORA CORDEIRO; et al. ydroxychloroquine blood levels predicts flare in childhood-onset lupus nephriti. Lupus, v. 31, n. 1, DEC 2021. (17/14352-7, 15/03756-4)

CLAUDINO FORMIGA, FRANCISCO FELLIPE; SILVA, CLOVIS ARTUR; PEDROSA, TATIANA DO NASCIMENTO; AIKAWA, NADIA EMI; PASOTO, SANDRA GOFINET; GARCIA, CRISTIANA COUTO; VIDAL CAPAO, ARTUR SILVA; DE OLIVEIRA MARTINS, VICTOR ADRIANO; TONACIO DE PROENCA, ADRIANA CORACINI; FULLER, RICARDO; et al. Influenza A/Singapore (H3N2) component vaccine in systemic lupus erythematosus: A distinct pattern of immunogenicity. Lupus, v. 30, n. 12, AUG 2021. (18/09937-9, 17/14352-7, 10/10749-0, 15/03756-4, 18/16162-3)

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