Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy

• Grant number: 15/03756-4
• Support Opportunities: Research Projects - Thematic Grants
• Start date: March 01, 2017
• End date: February 28, 2023
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Eloisa Silva Dutra de Oliveira Bonfá
• Grantee: Eloisa Silva Dutra de Oliveira Bonfá
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Pesquisadores principais: Clovis Artur Almeida da Silva ; Nádia Emi Aikawa ; Sandra Gofinet Pasoto
• Associated researchers: Alberto José da Silva Duarte ; Ana Cristina de Medeiros Ribeiro ; Carla Gonçalves Schahin Saad ; Eduardo Ferreira Borba Neto ; Esper Georges Kallás ; Gilberto de Nucci ; Luis Felipe das Chagas e Silva de Carvalho ; Pedro Carlos Carricondo ; Rosa Maria Rodrigues Pereira ; Valdemir Melechco Carvalho ; Vilma dos Santos Trindade Viana
• Associated research grant(s): 17/03983-6 - Liquid chromatography coupled to mass spectrometry (2015/03756-4), AP.EMU
• Associated scholarship(s): 22/09565-0 - Post-Covid-19 syndrome in patients with autoimmune rheumatological diseases, BP.IC; 22/09566-6 - Immunogenicity and safety of booster doses of CoronaVac vaccine in patients with autoimmune rheumatologic diseases patients, BP.IC; 21/08455-3 - Immunogenicity and safety of Coronavac vaccine in patients with autoimmune rheumatologic diseases: primary Sjörgren syndrome, BP.IC; + associated scholarships 21/06613-0 - Immunogenicity and safety of CoronaVac vaccine in patients with autoimmune rheumatic diseases: rheumatoid arthritis, BP.IC; 21/06615-3 - Immunogenicity and safety of CoronaVac vaccine in patients with autoimmune rheumatologic diseases: Juvenile systemic erythemesus lupus, BP.IC; 21/06616-0 - Validation of dry sample devices (Dried Blood Spot) for the therapeutic monitoring of hydroxychloroquine in rheumatic diseases, BP.IC; 20/11677-5 - Analysis of the immune profile of saliva and serum of patients with primary Sjögren's Syndrome, BP.IC; 20/09367-8 - Analysis of blood hydroxychlorochine levels in patients with primary Sjogren Syndrome and possible correlation with the disease activity, BP.DD; 20/02625-1 - Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy, BP.TT; 19/21211-6 - Salivary hydroxychloroquine levels: relevance in juvenile systemic lupus erythematosus (JSLE) disease activity and renal disease activity in adult systemic lupus erythematosus, BP.IC; 19/21173-7 - Evaluation of the treatment of cutaneous lupus erythematosus with thalidomide: clinical, laboratory and histological factors associated with clinical response and adverse effects, BP.IC; 19/17272-0 - Relevance of monitoring blood levels compared to salivar levels of drugs used in rheumatic autoimmune diseases: adherence and understanding the possible underlying mechanisms involved in effectiveness and in adverse effects, BP.PD; 18/21594-0 - Analysis of the immune profile of saliva and serum of patients with primary Sjögren's syndrome, BP.IC; 18/09937-9 - Analysis of the immune profile of saliva and serum of patients with primary Sjogren's Syndrome, BP.DD; 17/14352-7 - Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy, BP.PD; 17/11516-9 - Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy, BP.PD; 17/11854-1 - Assessment of serum levels of anti-tumor necrosis factor (anti-TNF) and anti-drug antibodies (ADA) in patients with chronic inflammatory arthritis: ankylosing spondylitis and psoriatic arthritis, BP.IC; 17/11644-7 - Blood and salivary levels of hydroxychloroquine: relevance in juvenile systemic lupus erythematosus disease (JSLE), in kidney disease in adult SLE activity and in alpha-interferon / TNF production by plasmacytoid dendritic cells, BP.TT; 17/07966-9 - Assessment of serum levels of anti-tumor necrosis factor (anti-TNF) and anti-drug antibodies (ADA) in patients with chronic inflammatory arthritis: ankylosing spondylitis and psoriatic arthritis, BP.IC; 17/07964-6 - Evaluation of serum levels of anti-tumor necrosis factor (antiTNF) and anti-drug (ada) antibodies in patients with chronic inflammatory arthritis - juvenile idiopathic arthritis, BP.IC - associated scholarships

Abstract

No drug treatment is completely free of risk and lack of response, adverse events and poor adherence may affect its effectiveness. There is also a large inter-individual variability in response to treatments with regard to efficacy and toxicity, and for many drugs, there is also a period of weeks to months to establish its efficacy. Within this context, this project aims to evaluate the importance of monitoring blood levels and salivary drug used in rheumatic autoimmune diseases in the monitoring of adherence to therapy. In addition, this project intends to use the monitoring of drug levels, based on pharmacokinetic studies and pharmacokinetics/pharmacodynamics modeling, to broaden the understanding of the possible cellular, tissue and immunological mechanisms involved in efficacy and adverse effects of these drugs with the prospect of reducing the damage and maintain therapeutic efficacy. The high-performance liquid chromatography (HPLC) coupled to mass spectrometry, which will be used to evaluate hydroxychloroquine, thalidomide, glucocorticoids, is considered the gold standard technology to qualitative and quantitative analysis of drugs in blood and its comparison with the dosage in the saliva is an improvement in simplification of the process. The implementation of this methodology dedicated to research in our center, with the necessary training of human resources, will enable the standardization and availability of this advanced technology to other muldisciplinary projects in various areas of science. For biological agents the focus will be on the understanding the loss of efficacy and the possible role of anti-TNF antibodies using ELISA capture methodology.This thematic project will be divided into four sections with their respective sub-projects according to the medications that will be studied: hydroxychloroquine, thalidomide, biologic agents and glucocorticoids. (AU)

Scientific publications

(126)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PINTO, ANA JESSICA; DUNSTAN, DAVID W.; OWEN, NEVILLE; BONFA, ELOISA; GUALANO, BRUNO. Combating physical inactivity during the COVID-19 pandemic. Nature Reviews Rheumatology, APR 2020. (15/26937-4, 17/13552-2, 18/19418-9, 15/03756-4)

LOURENCO, DANIELA M. R.; ARAUJO, DANIEL B.; AIKAWA, NADIA E.; YAMAKAMI, LUCAS Y. S.; BORBA, EDUARDO F.; MACIEL, GUSTAVO A. R.; SOARES-JUNIOR, JOSE M.; BARACAT, EDMUND C.; PEREIRA, ROSA M. R.; BONFA, ELOISA; et al. Adrenal steroidogenesis and ovarian reserve in adult childhood-onset systemic lupus erytematosus patients. CLINICAL RHEUMATOLOGY, MAR 2021. (15/03756-4)

THAIS T. FINK; HELOISA H.S. MARQUES; BRUNO GUALANO; LIVIA LINDOSO; VERA BAIN; CAMILLA ASTLEY; FERNANDA MARTINS; DENISE MATHEUS; OLIVIA M. MATSUO; PRISCILA SUGUITA; et al. Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital. Clinics, v. 76, 2021-11-26. (13/07914-8, 15/03756-4)

BRUNELLI, JULIANA BARBOSA; SCHMIDT, ANA RENATA; SALLUM, ADRIANA MALUF ELIAS; GOLDENSTEIN-SCHAINBERG, CLAUDIA; BONFA, ELOISA; SILVA, CLOVIS A.; AIKAWA, NADIA EMI. High rate of serious infection in juvenile idiopathic arthritis patients under biologic therapy in a real-life setting. MODERN RHEUMATOLOGY, v. 28, n. 2, p. 264-270, 2018. (14/14806-0, 15/03756-4)

BUSCATTI, IZABEL M.; CASELLA, BEATRIZ B.; AIKAWA, NADIA E.; WATANABE, ANDREA; FARHAT, SYLVIA C. L.; CAMPOS, LUCIA M. A.; SILVA, CLOVIS ARTUR. Henoch-Schonlein purpura nephritis: initial risk factors and outcomes in a Latin American tertiary center. CLINICAL RHEUMATOLOGY, v. 37, n. 5, p. 1319-1324, MAY 2018. (15/03756-4)

TISEO, B. C.; BONFA, E.; BORBA, E. F.; MUNHOZ, G. A.; WOOD, G. J. A.; SROUGI, M.; SILVA, C. A.; COCUZZA, M.. Complete urological evaluation including sperm DNA fragmentation in male systemic lupus erythematosus patients. Lupus, v. 28, n. 1, p. 59-65, JAN 2019. (15/03756-4, 14/14806-0)

GUALANO, BRUNO; BONFA, ELOISA; PEREIRA, ROSA M. R.; SILVA, CLOVIS A.. Physical activity for paediatric rheumatic diseases: standing up against old paradigms. Nature Reviews Rheumatology, v. 13, n. 6, p. 368-379, JUN 2017. (15/03756-4)

PINTO, ANA JESSICA; ROSCHEL, HAMILTON; DE SA PINTO, ANA LUCIA; LIMA, FERNANDA RODRIGUES; RODRIGUES PEREIRA, ROSA MARIA; SILVA, CLOVIS ARTUR; BONFA, ELOISA; GUALANO, BRUNO. Physical inactivity and sedentary behavior: Overlooked risk factors in autoimmune rheumatic diseases?. AUTOIMMUNITY REVIEWS, v. 16, n. 7, p. 667-674, JUL 2017. (15/26937-4, 15/03756-4)

NOVAK, V, G.; MOLINARI, B. C.; FERREIRA, J. C.; SAKAMOTO, A. P.; TERRERI, M. T.; PEREIRA, R. M. R.; SAAD-MAGALHAES, C.; AIKAWA, N. E.; CAMPOS, L. M.; LEN, C. A.; et al. Characteristics of 1555 childhood-onset lupus in three groups based on distinct time intervals to disease diagnosis: a Brazilian multicenter study. Lupus, v. 27, n. 10, p. 1712-1717, SEP 2018. (15/03756-4)

TRINDADE, VITOR CAVALCANTI; CARNEIRO-SAMPAIO, MAGDA; BONFA, ELOISA; SILVA, CLOVIS ARTUR. An Update on the Management of Childhood-Onset Systemic Lupus Erythematosus. PEDIATRIC DRUGS, v. 23, n. 4, p. 331-347, JUL 2021. (15/03756-4)

MENDES, CRISTIANE; VIANA, VILMA S. T.; PASOTO, SANDRA G.; LEON, ELAINE P.; BONFA, ELOISA; SAMPAIO-BARROS, PERCIVAL D.. Clinical and laboratory features of African-Brazilian patients with systemic sclerosis. CLINICAL RHEUMATOLOGY, v. 39, n. 1, p. 9-17, JAN 2020. (15/03756-4)

TOMIOKA, RENATO B.; FERREIRA, GABRIELA R. V.; AIKAWA, NADIA E.; MACIEL, GUSTAVO A. R.; SERAFINI, PAULO C.; SALLUM, ADRIANA M.; CAMPOS, LUCIA M. A.; GOLDESTEIN-SCHAINBERG, CLAUDIA; BONFA, ELOISA; SILVA, CLOVIS A.. Non-steroidal anti-inflammatory drug induces luteinized unruptured follicle syndrome in young female juvenile idiopathic arthritis patients. CLINICAL RHEUMATOLOGY, v. 37, n. 10, p. 2869-2873, OCT 2018. (15/03756-4, 14/14806-0)

AIKAWA, NADIA EMI; KANDA KUPA, LEONARD DE VINCI; MEDEIROS-RIBEIRO, ANA CRISTINA; SCHAHIN SAAD, CARLA GONCALVES; NEVES YUKI, EMILY FIGUEIREDO; PASOTO, SANDRA GOFINET; ROJO, PRISCILA TAGLIAFERRO; RODRIGUES PEREIRA, ROSA MARIA; SHINJO, SAMUEL KATSUYUKI; SAMPAIO-BARROS, PERCIVAL DEGRAVA; et al. Increment of immunogenicity after third dose of a homologous inactivated SARS-CoV-2 vaccine in a large population of patients with autoimmune rheumatic diseases. ANNALS OF THE RHEUMATIC DISEASES, v. 81, n. 7, p. 8-pg., 2022-03-10. (20/09367-8, 19/17272-0, 15/03756-4, 18/09937-9)

MEDEIROS-RIBEIRO, ANA CRISTINA; BONFIGLIOLI, KARINA ROSSI; DOMICIANO, DIOGO SOUZA; SHIMABUCO, ANDREA YUKIE; DA SILVA, HENRIQUE CARRICO; SAAD, CARLA G. S.; YUKI, EMILY FIGUEIREDO NEVES; PASOTO, SANDRA GOFINET; RENNER ARAUJO, CARLO SCOGNAMIGLIO; NAKAI, TATIANE LIE; et al. Distinct impact of DMARD combination and monotherapy in immunogenicity of an inactivated SARS-CoV-2 vaccine in rheumatoid arthritis. ANNALS OF THE RHEUMATIC DISEASES, v. 81, n. 5, p. 10-pg., 2022-02-07. (21/06613-0, 17/14352-7, 19/17272-0, 15/03756-4)

DINIZ, MARIA DE FATIMA RODRIGUES; KOZU, KATIA TOMIE; ELIAS, ADRIANA MALUF; LIANZA, ALESSANDRO CAVALCANTI; SAWAMURA, KAREN SAORI SHIRAISHI; MENEZES, CAROLINA ROCHA BRITO; FERREIRA, JULIANA CAIRES DE OLIVEIRA ACHILI; SILVA, CLOVIS ARTUR; LEAL, GABRIELA NUNES. Echocardiographic study of juvenile dermatomyositis patients: new insights from speckle-tracking-derived strain. CLINICAL RHEUMATOLOGY, v. 40, n. 4, p. 1497-1505, APR 2021. (15/03756-4)

GABRIEL F. RAMOS; VANESSA P. RIBEIRO; MARIANA P. MERCADANTE; MAIRA P. RIBEIRO; ARTUR F. DELGADO; SYLVIA C.L. FARHAT; MARTA M. LEAL; HELOISA H. MARQUES; VICENTE ODONE-FILHO; UENIS TANNURI; et al. Mortalidade entre adolescentes e adultos jovens com doenças crônicas durante 16 anos: estudo em um hospital terciário da América Latina. Jornal de Pediatria, v. 95, n. 6, p. 667-673, 2019-11-25. (15/03756-4)

GERALDO FILHO BUSATTO; CLOVIS ARTUR SILVA; ANTONIO JOSÉ RODRIGUES PEREIRA; ELOISA BONFÁ; TARCÍSIO ELOY PESSOA DE BARROS-FILHO. Scientific legacy of COVID-19 at the FMUSP-HC academic health system: current status and implications for the future. Clinics, v. 76, 2021-12-08. (15/03756-4)

SIGNORELLI, FLAVIO; BALBI, GUSTAVO GUIMARAES MOREIRA; AIKAWA, NADIA E.; SILVA, CLOVIS A.; KUPA, LEONARD DE VINCI KANDA; MEDEIROS-RIBEIRO, ANA C.; YUKI, EMILY F. N.; PASOTO, SANDRA G.; SAAD, CARLA G. S.; BORBA, EDUARDO F.; et al. Immunogenicity, safety, and antiphospholipid antibodies after SARS-CoV-2 vaccine in patients with primary antiphospholipid syndrome. Lupus, v. 31, n. 8, p. 11-pg., 2022-05-20. (19/17272-0, 15/03756-4)

SAKAMOTO, ANA P.; SILVA, CLOVIS A.; ISLABAO, ALINE G.; NOVAK, GLAUCIA, V; MOLINARI, BEATRIZ; NOGUEIRA, PAULO K.; PEREIRA, ROSA M. R.; SAAD-MAGALHAES, CLAUDIA; CLEMENTE, GLEICE; PIOTTO, DANIELA P.; et al. Chronic kidney disease in patients with childhood-onset systemic lupus erythematosus. Pediatric Nephrology, v. N/A, p. 12-pg., 2022-11-21. (15/03756-4)

CLOVIS ARTUR SILVA; LEONARD DE VINCI KANDA KUPA; ANA CRISTINA MEDEIROS-RIBEIRO; SANDRA GOFINET PASOTO; CARLA GONÇALVES SCHAHIN SAAD; EMILY FIGUEIREDO NEVES YUKI; JOAQUIM IVO VASQUES DANTAS LANDIM; VICTOR HUGO FERREIRA E LÉDA; LUISA SACCHI DE CAMARGO CORREIA; ARTUR FONSECA SARTORI; et al. Post-acute COVID-19 in three doses vaccinated autoimmune rheumatic diseases patients: frequency and pattern of this condition. ADVANCES IN RHEUMATOLOGY, v. 63, 2023-09-01. (22/09565-0, 22/09566-6, 19/17272-0, 19/21173-7, 15/03756-4, 21/08455-3, 18/09937-9)

BONFA, ELOISA; GOSSEC, LAURE; ISENBERG, DAVID A.; LI, ZHANGUO; RAYCHAUDHURI, SOUMYA. How COVID-19 is changing rheumatology clinical practice. Nature Reviews Rheumatology, v. 17, n. 1, p. 5-pg., 2020-11-02. (15/03756-4)

SAKAMOTO, ANA P.; SILVA, CLOVIS A.; PITA, ANA C.; TRINDADE, VITOR C.; ISLABAO, ALINE G.; FIOROT, FERNANDA J.; LOPES, SANDRA R. M.; PEREIRA, ROSA M. R.; SAAD-MAGALHAES, CLAUDIA; RUSSO, GLEICE C. S.; et al. Risk factors for mortality in 1528 Brazilian childhood-onset systemic lupus erythematosus patients. Lupus, v. N/A, p. 10-pg., 2023-04-18. (15/03756-4)

PASOTO, SANDRA GOFINET; BORBA, EDUARDO FERREIRA; FORMIGA, FRANCISCO FELLIPE CLAUDINO; DO NASCIMENTO PEDROSA, TATIANA; AIKAWA, NADIA EMI; DE SIQUEIRA, MARILDA AGUDO MENDONCA TEIXEIRA; CAPAO, ARTUR SILVA VIDAL; DE PROENCA, ADRIANA CORACINI TONACIO; FULLER, RICARDO; YUKI, EMILY FIGUEIREDO NEVES; et al. Robust immunogenicity to the H3N2 component of influenza A vaccine in primary Sjogren syndrome. CLINICAL RHEUMATOLOGY, v. 42, n. 9, p. 7-pg., 2023-06-12. (17/14352-7, 18/16162-3, 15/03756-4)

PINTO, ANA JESSICA; DUNSTAN, DAVID W.; OWEN, NEVILLE; BONFA, ELOISA; GUALANO, BRUNO. Combating physical inactivity during the COVID-19 pandemic. Nature Reviews Rheumatology, v. 16, n. 7, p. 2-pg., 2020-04-30. (17/13552-2, 18/19418-9, 15/26937-4, 15/03756-4)

BRUNELLI, JULIANA BARBOSA; SILVA, CLOVIS ALMEIDA; PASOTO, SANDRA GOFINET; SCHAHIN SAA, CARLA GONCALVES; KOZU, KATIA TOMIE; GOLDENSTEIN-SCHAINBERG, CLAUDIA; LEON, ELAINE PIRES; VENDRAMINI, MARGARETE B. G.; FONTOURA, NICOLE; BONFA, ELOISA; et al. Anti-adalimumab antibodies kinetics: an early guide for juvenile idiopathic arthritis (JIA) switching. CLINICAL RHEUMATOLOGY, v. 39, n. 2, p. 7-pg., 2019-11-09. (15/03756-4)

YUKI, EMILY F. N.; BORBA, EDUARDO F.; PASOTO, SANDRA G.; SEGURO, LUCIANA P.; LOPES, MICHELLE; SAAD, CARLA G. S.; MEDEIROS-RIBEIRO, ANA CRISTINA; SILVA, CLOVIS A.; DE ANDRADE, DANIELI C. O.; KUPA, LEONARD DE VINCI K.; et al. Impact of Distinct Therapies on Antibody Response to SARS-CoV-2 Vaccine in Systemic Lupus Erythematosus. ARTHRITIS CARE & RESEARCH, v. 74, n. 4, p. 10-pg., 2022-03-04. (15/03756-4, 17/14352-7, 19/17272-0, 21/06615-3)

SAMPAIO-BARROS, PERCIVAL DEGRAVA; MEDEIROS-RIBEIRO, ANA CRISTINA; LUPPINO-ASSAD, ANA PAULA; MIOSSI, RENATA; DA SILVA, HENRIQUE CARRICO; YUKI, EMILY F. V. N.; PASOTO, SANDRA G.; SAAD, CARLA G. S.; SILVA, CLOVIS A.; KUPA, LEONARD V. K.; et al. SARS-CoV-2 vaccine in patients with systemic sclerosis: impact of disease subtype and therapy. RHEUMATOLOGY, v. 61, n. SI2, p. 6-pg., 2021-12-11. (15/03756-4, 19/17272-0)

AIKAWA, NADIA E.; KUPA, LEONARD V. K.; SILVA, CLOVIS A.; SAAD, CARLA G. S.; PASOTO, SANDRA G.; YUKI, EMILY F. N.; FUSCO, SOLANGE R. G.; SHINJO, SAMUEL K.; ANDRADE, DANIELI C. O.; SAMPAIO-BARROS, PERCIVAL D.; et al. Strong response after fourth dose of mRNA COVID-19 vaccine in autoimmune rheumatic diseases patients with poor response to inactivated vaccine. RHEUMATOLOGY, v. N/A, p. 6-pg., 2022-05-26. (15/03756-4, 19/17272-0)

LANG, MARIA G.; VINAGRE, CARMEN G. C.; BONFA, ELOISA; FREITAS, FATIMA R.; PASOTO, SANDRA G.; BRITO, TATIANE S.; SEGURO, LUCIANA P. C.; MARANHAO, RAUL C.; BORBA, EDUARDO F.. Hydroxychloroquine increased cholesterol transfer to high-density lipoprotein in systemic lupus erythematosus: A possible mechanism for the reversal of atherosclerosis in the disease. Lupus, v. 31, n. 6, p. 7-pg., 2022-03-25. (15/03756-4, 17/14352-7, 14/03742-0)

PALMEIRA, PATRICIA; BARBUTO, JOSE PRIME ALEXANDRE M.; SILVA, CLOVIS ARTUR A.; CARNEIRO-SAMPAIO, MAGDA. Why is SARS-CoV-2 infection milder among children?. Clinics, v. 75, p. 5-pg., 2020-01-01. (15/03756-4, 14/50489-9)

LIANZA, ALESSANDRO C.; LEAL, GABRIELA N.; AIKAWA, NADIA E.; KOZU, KATIA T.; DINIZ, MARIA DE FATIMA R.; SAWAMURA, KAREN S. S.; MENEZES, CAROLINA R. B.; MARTINS, CAMILA LINO; CAMPOS, LUCIA M.; ELIAS, ADRIANA M.; et al. Heart function in juvenile idiopathic arthritis patients: A biventricular two-dimensional speckle-tracking echocardiography study. MODERN RHEUMATOLOGY, v. 32, n. 6, p. 7-pg., 2021-10-06. (15/03756-4)

CLOVIS ARTUR SILVA; LÍGIA BRUNI QUEIROZ; CLAUDIA DE BRITO FONSECA; LUÍS EDUARDO VARGAS DA SILVA; BENITO LOURENÇO; HELOISA HELENA SOUSA MARQUES. Spotlight for healthy adolescents and adolescents with preexisting chronic diseases during the COVID-19 pandemic. Clinics, v. 75, 2020-05-08. (15/03756-4)

HOLLAND, MICHAEL J.; BERESFORD, MICHAEL W.; FELDMAN, BRIAN M.; HUGGINS, JENNIFER; NORAMBUENA, XIMENA; SILVA, CLOVIS A.; SUSIC, GORDANA; SZTAJNBOK, FLAVIO; UZIEL, YOSEF; APPENZELLER, SIMONE; et al. Measuring Disease Damage and Its Severity in Childhood-Onset Systemic Lupus Erythematosus. ARTHRITIS CARE & RESEARCH, v. 70, n. 11, p. 1621-1629, NOV 2018. (15/03756-4)

LOURENCO, DANIELA M. R.; ARAUJO, DANIEL B.; AIKAWA, NADIA E.; YAMAKAMI, LUCAS Y. S.; BORBA, EDUARDO F.; MACIEL, GUSTAVO A. R.; SOARES-JUNIOR, JOSE M.; BARACAT, EDMUND C.; PEREIRA, ROSA M. R.; BONFA, ELOISA; et al. Adrenal steroidogenesis and ovarian reserve in adult childhood-onset systemic lupus erytematosus patients. CLINICAL RHEUMATOLOGY, v. 40, n. 9, p. 3651-3658, SEP 2021. (15/03756-4)

MEDEIROS-RIBEIRO, ANA C.; AIKAWA, NADIA E.; SAAD, CARLA G. S.; YUKI, EMILY F. N.; PEDROSA, TATIANA; FUSCO, SOLANGE R. G.; ROJO, PRISCILA T.; PEREIRA, ROSA M. R.; SHINJO, SAMUEL K.; ANDRADE, DANIELI C. O.; et al. Immunogenicity and safety of the CoronaVac inactivated vaccine in patients with autoimmune rheumatic diseases: a phase 4 trial. Nature Medicine, v. 27, n. 10, JUL 2021. (18/09937-9, 17/14352-7, 19/21173-7, 15/03756-4, 20/11677-5)

DUARTE, NILO J. C.; KUPA, LEONARD V. K.; FERREIRA-FILHO, JULIO C. R.; FONTOURA, NICOLE; CHALOM, MARC Y.; ROMANO, PASCHOALINA; EBNER, PERSIO A. R.; SILVA, CLOVIS A. A.; CARVALHO, VALDEMIR M.; BONFA, ELOISA. UHPLC-MS/MS Method for Determination of Hydroxychloroquine and Its Main Metabolites in Oral Fluid and Whole Blood for Therapeutic Drug Monitoring. JOURNAL OF APPLIED LABORATORY MEDICINE, v. 6, n. 4, p. 868-880, JUL 2021. (15/03756-4, 17/11644-7, 17/11516-9, 19/17272-0, 17/03983-6)

LIMA FARHAT, SYLVIA COSTA; EJNISMAN, CAROLINA; FERREIRA ALVES, ANDRESSA GUARIENTO; GIACOMIN GOULART, MARIA FERNANDA; DE FARIA COIMBRA LICHTENFELS, ANA JULIA; FERREIRA BRAGA, ALFESIO LUIS; AMADOR PEREIRA, LUIZ ALBERTO; ELIAS, ADRIANA MALUF; SILVA, CLOVIS A.. Air pollution influence on serum inflammatory interleukins: A prospective study in childhood-onset systemic lupus erythematous patients. Lupus, v. 30, n. 14, DEC 2021. (13/21508-2, 15/03756-4)

MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; ASTLEY, CAMILLA; IRAHA, AMANDA YURI; PINTO, ANA JESSICA; MARQUES, ISABELA GOUVEIA; CORDEIRO AMARANTE, MILLA; REZENDE, NATHALIA SAFFIOTI; SIECZKOWSKA, SOFIA MENDES; FRANCO, TATHIANE CHRISTINE; et al. Changes in Eating Habits and Sedentary Behavior During the COVID-19 Pandemic in Adolescents With Chronic Conditions. FRONTIERS IN PEDIATRICS, v. 9, DEC 13 2021. (19/20814-9, 19/14819-8, 19/14820-6, 16/00006-7, 17/13552-2, 19/15231-4, 15/03756-4, 15/26937-4)

ETRUSCO ZARONI SANTOS, ANA CAROLINA; LUGLIO, MICHELE; DELGADO, ARTUR FIGUEIREDO; SANTO VIEIRA SCHUWARTZ, CONSTANCE DELL; SOUSA MARQUES, HELOISA HELENA; DE MIRANDA VALOES, CLARISSA CARVALHO; CABRERA DOMINGUEZ, MARIA ANDREINA; DE CARVALHO, WERTHER BRUNOW; SILVA, CLOVIS ARTUR; DUARTE-NETO, AMARO NUNES. Acute petrified myocardium associated with meningococcal sepsis in childhood-onset systemic lupus erythematous: a fatal case. Revista do Instituto de Medicina Tropical de São Paulo, v. 61, 2019. (15/03756-4)

AIKAWA, NADIA E.; KUPA, LEONARD V. K.; PASOTO, SANDRA G.; MEDEIROS-RIBEIRO, ANA C.; YUKI, EMILY F. N.; SAAD, CARLA G. S.; PEDROSA, TATIANA; FULLER, RICARDO; SHINJO, SAMUEL K.; SAMPAIO-BARROS, PERCIVAL D.; et al. mmunogenicity and safety of two doses of the CoronaVac SARS-CoV-2 vaccine in SARS-CoV-2 seropositive and seronegative patients with autoimmune rheumatic diseases in Brazil: a subgroup analysis of a phase 4 prospective stud. LANCET RHEUMATOLOGY, v. 4, n. 2, p. E113-E124, FEB 2022. (17/14352-7, 19/17272-0, 15/03756-4)

PASOTO, SANDRA GOFINET; DE OLIVEIRA MARTINS, VICTOR ADRIANO; BONFA, ELOISA. Sjogren's syndrome and systemic lupus erythematosus: links and risks. OPEN ACCESS RHEUMATOLOGY-RESEARCH AND REVIEWS, v. 11, p. 33-45, 2019. (18/09937-9, 15/03756-4)

KUHNE, A. C. A.; PITTA, A. C.; GALASSI, S. C.; GONCALVES, A. M. F.; CARDOSO, A. C. A.; PAZ, J. A.; CAMPOS, L. M. A.; SILVA, C. A.. Munchausen by proxy syndrome mimicking childhood-onset systemic lupus erythematosus. Lupus, v. 28, n. 2, p. 249-252, FEB 2019. (15/03756-4)

PITTA, ANA CLAUDIA; VIOLA FERREIRA, GABRIELA RIBEIRO; TOMIOKA, RENATO BUSSADORI; RODRIGUES LOURENCO, DANIELA MENCARONI; KOZU, KATIA; AIKAWA, NADIA EMI; ELIAS SALLUM, ADRIANA MALUF; ARRUDA CAMPOS, LUCIA MARIA; NAJJAR ABDO, CARMITA HELENA; RODRIGUES PEREIRA, ROSA MARIA; et al. Sexual function in female juvenile idiopathic arthritis patients. ADVANCES IN RHEUMATOLOGY, v. 59, MAR 22 2019. (15/03756-4)

SETOUE, DEBORA N.; PITTA, ANA C.; FIOROT, FERNANDA J.; NASTRI, MARIANA M.; NOVAK, GLAUCIA V.; MOLINARI, BEATRIZ C.; OLIVEIRA, JULIANA C.; GORMEZANO, NATALI W.; SAKAMOTO, ANA P.; TERRERI, MARIA T.; et al. Symptomatic polyautoimmunity at diagnosis of 1463 childhood-onset lupus: A Brazilian multicenter study. AUTOIMMUNITY REVIEWS, v. 17, n. 8, p. 836-839, AUG 2018. (15/03756-4)

BRUNNER, HERMINE I.; HOLLAND, MICHAEL J.; BERESFORD, MICHAEL W.; ARDOIN, STACY P.; APPENZELLER, SIMONE; SILVA, CLOVIS A.; FLORES, FRANCISCO; AYDIN, PINAR OZGE AVAR; WENDERFER, SCOTT E.; LEVY, DEBORAH M.; et al. American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood-Onset Systemic Lupus Erythematosus. ARTHRITIS CARE & RESEARCH, v. 71, n. 5, p. 579-590, MAY 2019. (15/03756-4)

FARGETTI, SIMONE; UGOLINI-LOPES, MICHELLE R.; PASOTO, SANDRA G.; SEGURO, LUCIANA P. C.; SHINJO, SAMUEL K.; BONFA, ELOISA; BORBA, EDUARDO F.. Short- and Long-Term Outcome of Systemic Lupus Erythematosus Peripheral Neuropathy Bimodal Pattern of Onset and Treatment Response. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, v. 27, n. 6, p. S212-S216, SEP 2021. (15/03756-4)

PITTA, ANA C.; SILVA, CLOVIS A.; INSFRAN, CARLOS E.; PASOTO, SANDRA G.; TRINDADE, VITOR C.; NOVAK, V, GLAUCIA; SAKAMOTO, ANA P.; TERRERI, MARIA T.; PEREIRA, ROSA M. R.; MAGALHAES, CLAUDIA S.; et al. The new 2019-EULAR/ACR classification criteria specific domains at diagnosis can predict damage accrual in 670 childhood-onset systemic lupus erythematosus patients. Lupus, v. 30, n. 14, OCT 2021. (15/03756-4)

INSFRAN, CARLOS E.; AIKAWA, NADIA E.; PASOTO, SANDRA G.; FILHO, DILSON M. N.; FORMIGA, FRANCISCO F. C.; PITTA, ANA C.; BORBA, EDUARDO F.; RIBEIRO, CAROLINA T.; SILVA, CLOVIS A.; BONFA, ELOISA. 2019-EULAR/ACR classification criteria domains at diagnosis: predictive factors of long-term damage in systemic lupus erythematosus. CLINICAL RHEUMATOLOGY, NOV 2021. (18/16162-3, 15/03756-4)

ASTLEY, CAMILLA; SIECZKOWSKA, SOFIA MENDES; MARQUES, ISABELA GOUVEIA; IHARA, BIANCA PIRES; LINDOSO, LIVIA; MARTINS LAVORATO, SOFIA SIMAO; ARRUDA CAMPOS, LUCIA MARIA; RODRIGUES PEREIRA, ROSA MARIA; ELIAS, ADRIANA MALUF; AIKAWA, NADIA EMI; et al. Home-based exercise program for adolescents with juvenile dermatomyositis quarantined during COVID-19 pandemic: a mixed methods study. PEDIATRIC RHEUMATOLOGY, v. 19, n. 1, NOV 13 2021. (17/13552-2, 19/20814-9, 15/03756-4, 19/15231-4)

ISABELA GOUVEIA MARQUES; CAMILLA ASTLEY; SOFIA MENDES SIECZKOWSKA; AMANDA YURI IRAHA; TATHIANE CHRISTINE FRANCO; FABIANA INFANTE SMAIRA; BRUNA CARUSO MAZZOLANI; LUANA CRISTINA DO AMARAL MIRANDA; BIANCA PIRES IHARA; ROSA MARIA R. PEREIRA; et al. Lessons learned from a home-based exercise program for adolescents with pre-existing chronic diseases during the COVID-19 quarantine in Brazil. Clinics, v. 76, 2021-06-28. (17/13552-2, 15/03756-4, 19/14820-6, 19/14819-8, 19/15231-4, 16/00006-7, 19/20814-9)

IHARA, BIANCA P.; STRABELLI, CLAUDIA A. A.; SIMON, JULIANA R.; VIANA, VIVIANNE S. L.; SALLUM, ADRIANA M. E.; KOZU, KATIA T.; AIKAWA, NADIA E.; LEAL, GABRIELA N.; PEREIRA, MARIA F. B.; MARQUES, HELOISA H.; et al. Laboratory-confirmed pediatric COVID-19 in patients with rheumatic diseases: A case series in a tertiary hospital. Lupus, v. 30, n. 5, p. 856-860, APR 2021. (15/03756-4)

MAIRA P. RIBEIRO; AMARO N. DUARTE NETO; MARISA DOLHNIKOFF; LIVIA LINDOSO; BENITO LOURENCO; HELOISA H. MARQUES; MARIA F.B. PEREIRA; LILIAN M. CRISTOFANI; VICENTE ODONE FILHO; LUCIA M.A. CAMPOS; et al. Major discrepancy between clinical diagnosis of death and anatomopathological findings in adolescents with chronic diseases during 18-years. Clinics, v. 78, 2023-05-19. (15/03756-4)

YUKI, EMILY FIGUEIREDO NEVES; SILVA, CLOVIS A.; AIKAWA, NADIA E.; ROMITI, RICARDO; HEISE, CARLOS OTTO; BONFA, ELOISA; PASOTO, SANDRA GOFINET. Thalidomide and Lenalidomide for Refractory Systemic/Cutaneous Lupus Erythematosus Treatment. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, v. 27, n. 6, p. 12-pg., 2021-09-01. (15/03756-4)

FINK, THAIS T.; MARQUES, HELOISA H. S.; GUALANO, BRUNO; LINDOSO, LIVIA; BAIN, VERA; ASTLEY, CAMILLA; MARTINS, FERNANDA; MATHEUS, DENISE; MATSUO, OLIVIA M.; SUGUITA, PRISCILA; et al. Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital Thais. Clinics, v. 76, 2021. (15/03756-4)

DE SOUSA MARQUES, HELOISA HELENA; BADUE PEREIRA, MARIA FERNANDA; DOS SANTOS, ANGELICA CARREIRA; FINK, THAIS TOLEDO; YOSHINO DE PAULA, CAMILA SANSON; LITVINOV, NADIA; SCHVARTSMAN, CLAUDIO; DELGADO, ARTUR FIGUEIREDO; BENTO CICARONI GIBELLI, MARIA AUGUSTA; DE CARVALHOL, WERTHER BRUNOW; et al. Differences in children and adolescents with SARS-CoV-2 infection: a cohort study in a Brazilian tertiary referral hospital. Clinics, v. 76, 2021. (15/03756-4)

CLOVIS ARTUR SILVA; VITOR CAVALCANTI TRINDADE; ROBERTA CAPRETZ DOLIVEIRA ABEL; MARCELO OLIVEIRA SILVA; JOÃO FERNANDO VECCHI SANTOS; VERA HERMINA KALIKA KOCH; ANA PAULA SCOLEZE FERRER; ALEXANDRA BRENTANI; VICENTE ODONE-FILHO; UENIS TANNURI; et al. PEDIATRAS APÓS A RESIDÊNCIA MÉDICA: UM QUESTIONÁRIO SOBRE DADOS E PROBLEMAS PESSOAIS/PROFISSIONAIS. Revista Paulista de Pediatria, v. 39, 2020-08-03. (15/03756-4)

LEAL, GABRIELA NUNES; ASTLEY, CAMILA; LIMA, MARCOS SANTOS; RODRIGUES DINIZ, MARIA DE FATIMA; LIANZA, ALESSANDRO CAVALCANTI; SHIRAISHI SAWAMURA, KAREN SAORI; BRITO MENEZES, CAROLINA ROCHA; MARTINS RODRIGUES DA SILVA, CAMILA LINO; BAIN, VERA; IMADA, RODRIGO; et al. Segmental cardiac strain assessment by two-dimensional speckle-tracking echocardiography in surviving MIS-c patients: Correlations with myocardial flow reserve (MFR) by 13 N-ammonia PET-CT. ICROCIRCULATIO, v. 29, n. 3, p. 11-pg., 2022-02-20. (15/03756-4)

SOFIA S.M. LAVORATO; ALBERTO C. HELITO; VERA P.M.F.R. BARROS; DEBORAH F.P. ROZ; LIGIA P. SACCANI; LORENA V.M. MARTINIANO; LÍVIA M.L. LIMA; DANDARA C.C. LIMA; BENITO LOURENÇO; ROSA M.R. PEREIRA; et al. Assistance and health care provided to adolescents with chronic and immunosuppressive conditions in a tertiary university hospital during the COVID-19 pandemic. Clinics, v. 76, 2021-03-24. (15/03756-4)

PEDROSA, TATIANA; KANDA KUPA, LEONARD DE VINCI; PASOTO, SANDRA GOFINET; AIKAWA, NADIA EMI; BORBA, EDUARDO FERREIRA; DUARTE, NILO J. C.; LEON, ELAINE PIRES; SILVA, CLOVIS ARTUR; BONFA, ELOISA. The influence of obesity on hydroxychloroquine blood levels in lupus nephritis patients. Lupus, v. 30, n. 4, p. 554-559, APR 2021. (19/17272-0, 15/03756-4, 17/14352-7, 17/03983-6)

GUALANO, BRUNO; SAAD, CARLA G. S.; SIECZKOWSKA, SOFIA M.; LEMES, ITALO RIBEIRO; DA SILVA, RAFAEL PIRES; PINTO, ANA J.; MAZZOLANI, BRUNA C.; SMAIRA, FABIANA, I; GIL, SAULO; OLIVEIRA-JUNIOR, GERSIEL; et al. Effect of an exercise bout before the booster dose of an inactivated SARS-CoV-2 vaccine on immunogenicity in immunocompromised patients. Journal of Applied Physiology, v. 132, n. 3, p. 7-pg., 2022-03-01. (19/15231-4, 17/13552-2, 17/23688-9, 15/26937-4, 20/04877-8, 19/14820-6, 19/14819-8, 15/03756-4)

CLOVIS ARTUR SILVA; VITOR CAVALCANTI TRINDADE; AMANDA MONTEIRO DA CRUZ; BRUNA PACCOLA BLANCO; JOÃO FERNANDO VECCHI SANTOS; ALEXANDRE ARCHANJO FERRARO; VICENTE ODONE-FILHO; UENIS TANNURI; WERTHER BRUNOW CARVALHO; MAGDA CARNEIRO-SAMPAIO; et al. Profile of health professionals who completed a master’s, doctoral, or post-doctoral degree in one Brazilian pediatric program. Clinics, v. 75, 2020-04-17. (15/03756-4)

BRUNELLI, JULIANA BARBOSA; SILVA, CLOVIS ALMEIDA; PASOTO, SANDRA GOFINET; SCHAHIN SAA, CARLA GONCALVES; KOZU, KATIA TOMIE; GOLDENSTEIN-SCHAINBERG, CLAUDIA; LEON, ELAINE PIRES; VENDRAMINI, MARGARETE B. G.; FONTOURA, NICOLE; BONFA, ELOISA; et al. Anti-adalimumab antibodies kinetics: an early guide for juvenile idiopathic arthritis (JIA) switching. CLINICAL RHEUMATOLOGY, NOV 2019. (15/03756-4)

PRADO, L. L.; GONCALVES, C. R.; VIANA, V. T.; SAAD, C. G. S.; BONFA, E.. Anti-alpha-enolase antibodies in Behcet's disease: a marker of mucocutaneous and articular disease activity?. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v. 36, n. 6, 115, p. S28-S32, 2018. (15/03756-4)

BALMANT, BIANCA D.; TORRINHAS, RAQUEL S.; ROCHA, ILANNA M.; FONSECA, DANIELLE C.; FORMIGA, FRANCISCO F. C.; BONFA, ELOISA S. D. O.; BORBA, EDUARDO F.; WAITZBERG, DAN L.. SARS-CoV-2 infection, gut dysbiosis, and heterogeneous clinical results of hydroxychloroquine on COVID-19 therapy & mdash;Is there a link?. NUTRITION, v. 85, MAY 2021. (18/16162-3, 15/03756-4)

IHARA, BIANCA P.; LINDOSO, LIVIA M.; SETOUE, DEBORA N. D.; TANIGAVA, NICOLAS Y.; HELITO, ALBERTO C.; SIMON, JULIANA R.; VIANA, VIVIANNE S. L.; STRABELLI, CLAUDIA A. A.; PEDROSO, CAMILLA A. A.; SIECZKOWSKA, SOFIA M.; et al. COVID-19 quarantine in adolescents with autoimmune rheumatic diseases: mental health issues and life conditions. CLINICAL RHEUMATOLOGY, v. N/A, p. 10-pg., 2022-06-15. (15/03756-4)

LIVIA LINDOSO; CAMILLA ASTLEY; LIGIA BRUNI QUEIROZ; BRUNO GUALANO; ROSA MARIA RODRIGUES PEREIRA; UENIS TANNURI; LÚCIA MARIA MATTEI DE ARRUDA CAMPOS; BENITO LOURENÇO; RICARDO KATSUYA TOMA; KARINA MEDEIROS; et al. Physical and mental health impacts during COVID-19 quarantine in adolescents with preexisting chronic immunocompromised conditions. Jornal de Pediatria, v. 98, n. 4, p. 350-361, 2022-07-25. (15/03756-4)

MOISÉS DE FREITAS LAURENTINO; LIVIA LINDOSO; CAMILLA ASTLEY; SOFIA SIMÃO MARTINS LAVORATO; BIANCA PIRES IHARA; DANDARA CARVALHO CASADO DE LIMA; BRUNO GUALANO; LÍGIA BRUNI QUEIROZ; ROSA MARIA RODRIGUES PEREIRA; GUILHERME VANONI POLANCZYK; et al. Impacto da COVID-19 no funcionamento físico e mental de adolescentes com deficiência em organização não governamental esportiva. Revista Paulista de Pediatria, v. 41, 2022-11-14. (15/03756-4)

ASTLEY, CAMILLA; BADUE PEREIRA, MARIA FERNANDA; LIMA, MARCOS SANTOS; BUCHPIGUEL, CARLOS ALBERTO; CARNEIRO, CAMILA G.; SAPIENZA, MARCELO TATIT; LEAL, GABRIELA NUNES; LEITE DO PRADO, DANILO MARCELO; PECANHA, TIAGO; SIECZKOWSKA, SOFIA MENDES; et al. In-depth cardiovascular and pulmonary assessments in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: A case series study. PHYSIOLOGICAL REPORTS, v. 10, n. 5, p. 9-pg., 2022-03-01. (15/03756-4, 19/15231-4, 17/13552-2)

PASOTO, SANDRA GOFINET; HALPERN, ARI STIEL RADU; NORONHA GUEDES, LISSIANE KARINE; MEDEIROS RIBEIRO, ANA CRISTINA; FIGUEIREDO YUKI, EMILY NEVES; SCHAHIN SAAD, CARLA GONCALVES; ALMEIDA DA SILVA, CLOVIS ARTUR; KANDA KUPA, LEONARD DE VINCI; BETANCOURT VILLAMARIN, LORENA ELIZABETH; DE OLIVEIRA MARTINS, VICTOR ADRIANO; et al. Inactivated SARS-CoV-2 vaccine in primary Sjogren's syndrome: humoral response, safety, and effects on disease activity. CLINICAL RHEUMATOLOGY, v. 41, n. 7, p. 11-pg., 2022-03-19. (20/11677-5, 20/09367-8, 19/17272-0, 17/14352-7, 15/03756-4, 18/09937-9, 21/08455-3)

FIOROT, FERNANDA J.; ISLABAO, ALINE G.; PEREIRA, ROSA M.; TERRERI, MARIA T.; SAAD-MAGALHAES, CLAUDIA; NOVAK, V, GLAUCIA; MOLINARI, BEATRIZ C.; SAKAMOTO, ANA P.; AIKAWA, NADIA E.; CAMPOS, LUCIA M.; et al. Disease presentation of 1312 childhood-onset systemic lupus erythematosus: influence of ethnicity. CLINICAL RHEUMATOLOGY, v. 38, n. 10, p. 2857-2863, OCT 2019. (15/03756-4)

CAROLINE GOUVEIA BUFF PASSONE; SANDRA JOSEFINA GRISI; SYLVIA COSTA FARHAT; THAIS DELLA MANNA; ANTONIO CARLOS PASTORINO; RENATA ANTUNES ALVENO; CAROLINE VASCONCELOS SÁ MIRANDA; AURORA ROSARIA WAETGE; MARIANA NUTTI CORDON; VICENTE ODONE-FILHO; et al. COMPLEXIDADE DA DOENÇA CRÔNICA PEDIÁTRICA: ESTUDO TRANVERSAL COM 16.237 PACIENTES SEGUIDOS POR MÚLTIPLAS ESPECIALIDADES MÉDICAS. Revista Paulista de Pediatria, v. 38, 2019-11-25. (15/03756-4)

FERREIRA, V, GABRIELA R.; TOMIOKA, RENATO B.; QUEIROZ, LIGIA B.; KOZU, KATIA; AIKAWA, NADIA E.; SALLUM, ADRIANA M. E.; SERAFINI, PAULO; TACLA, MARICY; BARACAT, EDMUND C.; PEREIRA, ROSA M. R.; et al. Lower genital tract infections in young female juvenile idiopathic arthritis patients. ADVANCES IN RHEUMATOLOGY, v. 59, n. 1, NOV 15 2019. (15/03756-4, 14/14806-0)

SHINJO, SAMUEL K.; DE SOUZA, FERNANDO H. C.; BORGES, ISABELA B. P.; DOS SANTOS, ALEXANDRE M.; MIOSSI, RENATA; MISSE, RAFAEL G.; MEDEIROS-RIBEIRO, ANA C.; SAAD, CARLA G. S.; YUKI, EMILY F. N.; PASOTO, SANDRA G.; et al. Systemic autoimmune myopathies: a prospective phase 4 controlled trial of an inactivated virus vaccine against SARS-CoV-2. RHEUMATOLOGY, v. N/A, p. 11-pg., 2021-10-19. (19/17272-0, 19/21211-6, 19/11776-6, 15/03756-4)

REINAN TAVARES CAMPOS; LORENA VASCONCELOS MESQUITA MARTINIANO; AMANDA KERLYN SANTOS LIRIO; KALESA ELIAS DE ARAUJO SOUZA; NATALIA ROSE; JULIANA MARTINS MONTEIRO DIAS; ANTÔNIO CARLOS ALVES CARDOSO; SYLVIA COSTA FARHAT; CLOVIS ARTUR SILVA. Violência não sexual contra crianças e adolescentes: um estudo em um hospital universitário e terciário da América Latina. Revista Paulista de Pediatria, v. 40, 2022-05-02. (15/03756-4)

MARIANA MACHADO FORTI NASTRI; BENITO LOURENÇO; LIGIA BRUNI QUEIROZ; LUIZ EDUARDO VARGAS DA SILVA; DANIELA MENCARONI RODRIGUES LOURENÇO; ANA PAULA BELTRAN MOSCHIONE CASTRO; CLOVIS ARTUR SILVA; ANTONIO CARLOS PASTORINO. Idiopathic musculoskeletal pain, musculoskeletal pain syndromes, and use of electronic devices in adolescents with asthma. Jornal de Pediatria, v. 98, n. 3, p. 270-275, 2022-06-06. (15/03756-4)

PATRICIA MORENO GRANGEIRO; MOISÉS DE FREITAS LAURENTINO; FERNANDA GÉA DE LUCENA GOMES; DANIELA SIMONE ALVAREZ; CÉSAR AUGUSTO MOREIRA; NATÁLIA ANGÉLICA DE SOUZA; JENNIFER MACENA BALBINO; CANDIDO LEONELLI; RICARDO MARCONDES MACÉA; CLOVIS ARTUR ALMEIDA DA SILVA. TELEATENDIMENTO A CRIANÇAS E ADOLESCENTES COM DEFICIÊNCIAS FÍSICAS DURANTE A PANDEMIA COVID-19. Acta Ortopédica Brasileira, v. 30, 2022-07-06. (15/03756-4)

GUALANO, BRUNO; LEMES, ITALO R.; SILVA, RAFAEL P.; PINTO, ANA J.; MAZZOLANI, BRUNA C.; SMAIRA, FABIANA, I; SIECZKOWSKA, SOFIA M.; AIKAWA, NADIA E.; PASOTO, SANDRA G.; MEDEIROS-RIBEIRO, ANA C.; et al. Association between physical activity and immunogenicity of an inactivated virus vaccine against SARS-CoV-2 in patients with autoimmune rheumatic diseases. BRAIN BEHAVIOR AND IMMUNITY, v. 101, p. 8-pg., 2022-03-01. (19/14819-8, 15/03756-4, 15/26937-4, 19/15231-4, 17/23688-9, 17/13552-2, 19/14820-6)

AIKAWA, NADIA EMI; BALBI, VERENA ANDRADE; BORBA, EDUARDO FERREIRA; TONACIO, ADRIANA CORACINI; SALLUM, ADRIANA MALUF ELIAS; CAMPOS, LUCIA MARIA ARRUDA; KOZU, KATIA TOMIE; VENDRAMINI, MARGARETE BORGES; FONTOURA, NICOLE; AZEVEDO, ADRIANA DE SOUZA; et al. Yellow fever vaccination in Brazil: Short-term safety and immunogenicity in juvenile autoimmune rheumatic diseases. VACCINE: X, v. 10, p. 4-pg., 2022-04-01. (15/03756-4, 18/16162-3)

ROSA M.R. PEREIRA; MARILIA A. DAGOSTIN; VALERIA F. CAPARBO; LUCAS P. SALES; SANDRA G. PASOTO; CLOVIS A. SILVA; EMILY F.N. YUKI; CARLA G.S. SAAD; ANA C. MEDEIROS-RIBEIRO; LEONARD V.K. KUPA; et al. Anti-SARS-CoV-2 inactivated vaccine in patients with ANCA-associated vasculitis: Immunogenicity, safety, antibody decay and the booster dose. Clinics, v. 78, 2023-02-27. (19/17272-0, 15/03756-4, 20/09367-8, 21/08455-3, 18/09937-9)

SILVA, CLOVIS A.; MEDEIROS-RIBEIRO, ANA C.; KUPA, LEONARD V. K.; YUKI, EMILY F. N.; PASOTO, SANDRA G.; SAAD, CARLA G. S.; FUSCO, SOLANGE R. G.; PEREIRA, ROSA M. R.; SHINJO, SAMUEL K.; HALPERN, ARI S. R.; et al. Immunogenicity decay and case incidence six months post Sinovac-CoronaVac vaccine in autoimmune rheumatic diseases patients. NATURE COMMUNICATIONS, v. 13, n. 1, p. 9-pg., 2022-10-03. (15/03756-4, 18/09937-9, 20/09367-8, 19/17272-0)

IZABEL MANTOVANI BUSCATTI; JULIANA RUSSO SIMON; VIVIANNE SARAIVA LEITAO VIANA; TAMIMA MOHAMAD ABOU ARABI; VITOR CAVALCANTI TRINDADE; ANA CAROLINA CORTEZ MAIA; LARA REGINA CAVALCANTE MELO; BIANCA PIRES IHARA; NADIA EMI AIKAWA; CLOVIS ARTUR SILVA. Dor abdominal intermitente na vasculite por IgA. Revista Paulista de Pediatria, v. 40, 2021-09-01. (15/03756-4)

YUKI, EMILY FIGUEIREDO NEVES; SOARES, RENATA; KUPA, LEONARD DE VINCI KANDA; HEISE, CARLOS OTTO; AIKAWA, NADIA EMI; ARNONE, MARCELO; ROMITI, RICARDO; PEDROSA, TATIANA DO NASCIMENTO; SILVA, CLOVIS ARTUR ALMEIDA DA; BONFA, ELOISA; et al. One-year prospective nerve conduction study of thalidomide neuropathy in lupus erythematosus: Incidence, coasting effect and drug plasma levels. Lupus, v. 30, n. 6, MAR 2021. (15/03756-4, 19/17272-0, 17/14352-7)

IHARA, BIANCA P.; STRABELLI, CLAUDIA A. A.; SIMON, JULIANA R.; VIANA, VIVIANNE S. L.; SALLUM, ADRIANA M. E.; KOZU, KATIA T.; AIKAWA, NADIA E.; LEAL, GABRIELA N.; PEREIRA, MARIA F. B.; MARQUES, HELOISA H.; et al. Laboratory-confirmed pediatric COVID-19 in patients with rheumatic diseases: A case series in a tertiary hospital. Lupus, MAR 2021. (15/03756-4)

MARCO AURELIO PALAZZI SAFADI; CLOVIS ARTUR ALMEIDA DA SILVA. O ESPECTRO DESAFIADOR E IMPREVISÍVEL DA COVID-19 EM CRIANÇAS E ADOLESCENTES. Revista Paulista de Pediatria, v. 39, 2020-09-07. (15/03756-4)

PEDROSA, TATIANA; KUPA, LEONARD DE VINCI KANDA; AIKAWA, NADIA EMI; PASOTO, SANDRA GOFINET; BONFA, ELOISA; SILVA, CLOVIS ARTUR. Lupus nephritis-related issues during COVID-19 pandemic quarantine. Lupus, v. 29, n. 14, SEP 2020. (17/14352-7, 19/17272-0, 15/03756-4, 17/03983-6)

USUBA, FANY SOLANGE; SCHAHIN SAAD, CARLA GONCALVES; AIKAWA, NADIA EMI; NOVAES, PRISCILA; BERTACINI MORAES, JULIO CESAR; SANTO, RUTH MIYUKI; CARVALHO, JOZELIO FREIRE; BONFA, ELOISA; ALVES, MILTON RUIZ. Improvement of conjunctival cytological grade and tear production in Ankylosing Spondylitis patients under TNF inhibitors: a long-term follow-up. SCIENTIFIC REPORTS, v. 10, n. 1, JAN 15 2020. (15/03756-4)

SOARES-JR, J. M.; ESPOSITO SORPRESO, I. C.; NUNES CURADO, J. F.; FERREIRA FILHO, E. S.; DOS SANTOS SIMOES, R.; BONFA, E.; SILVA, C. A.; BARACAT, E. C.. Hormone therapy effect on menopausal systemic lupus erythematosus patients: a systematic review. CLIMACTERIC, v. N/A, p. 7-pg., 2022-04-19. (18/24224-9, 15/03756-4)

ALVENO, RENATA A.; MIRANDA, V, CAROLINE; PASSONE, CAROLINE G.; WAETGE, AURORA R.; HOJO, ELZA S.; FARHAT, SYLVIA C. L.; ODONE-FILHO, VICENTE; TANNURI, UENIS; CARVALHO, WERTHER B.; CARNEIRO-SAMPAIO, MAGDA; et al. Pacientes pediátricos crônicos em clínicas ambulatoriais: estudo em um hospital universitário da América Latina. Jornal de Pediatria, v. 94, n. 5, p. 539-545, SEP-OCT 2018. (15/03756-4)

PEDROSA, TATIANA N.; PASOTO, SANDRA G.; AIKAWA, NADIA E.; YUKI, EMILY F. N.; BORBA, EDUARDO F.; FERREIRA FILHO, JULIO C. R.; CARRICONDO, PEDRO C.; ZANETTI, CAIO B.; CONDE, PAOLA G.; DUARTE, NILO J. C.; et al. Understanding the dynamics of hydroxychloroquine blood levels in lupus nephritis. Lupus, v. 29, n. 6, MAR 2020. (15/03756-4, 17/11516-9, 17/11854-1, 17/14352-7, 17/11644-7)

CHALHOUB, NATHALIE E.; WENDERFER, SCOTT E.; LEVY, DEBORAH M.; ROUSTER-STEVENS, KELLY; AGGARWAL, AMITA; SAVANI, I, SONIA; RUTH, NATASHA M.; ARKACHAISRI, THASCHAWEE; QIU, TINGTING; MERRITT, ANGELA; et al. nternational Consensus for the Dosing of Corticosteroids in Childhood-Onset Systemic Lupus Erythematosus With Proliferative Lupus Nephriti. ARTHRITIS & RHEUMATOLOGY, v. 74, n. 2, JAN 2022. (15/03756-4)

BALBI, VERENA ANDRADE; SILVA, CLOVIS ARTUR; PEDROSA, TATIANA NASCIMENTO; RODRIGUES PEREIRA, ROSA MARIA; DE ARRUDA CAMPOS, LUCIA MARIA; LEON, ELAINE PIRES; DUARTE, NILO; CARVALHO, VALDEMIR MELECHCO; PASOTO, SANDRA GOFINT; DO ROSARIO, DEBORA CORDEIRO; et al. ydroxychloroquine blood levels predicts flare in childhood-onset lupus nephriti. Lupus, v. 31, n. 1, DEC 2021. (17/14352-7, 15/03756-4)

ANDREA YUKIE SHIMABUCO; ANA CRISTINA DE MEDEIROS-RIBEIRO; RENATA MIOSSI; KARINA ROSSI BONFIGLIOLI; JULIO CESAR BERTACINI DE MORAES; CELIO ROBERTO GONÇALVES; PERCIVAL DEGRAVA SAMPAIO-BARROS; CLAUDIA GOLDENSTEIN-SCHAINBERG; FERNANDO HENRIQUE CARLOS DE SOUZA; LEANDRO LARA DO PRADO; et al. Ankylosing spondylitis and psoriatic arthritis: revisiting screening of latent tuberculosis infection and its follow-up during anti-tumor necrosis factor therapy in an endemic area. Clinics, v. 75, 2020-11-11. (15/03756-4)

BRAIAN L.A. SOUSA; MAGDA SAMPAIO-CARNEIRO; WERTHER B. DE CARVALHO; CLOVIS A. SILVA; ALEXANDRE A. FERRARO. Differences among Severe Cases of Sars-CoV-2, Influenza, and Other Respiratory Viral Infections in Pediatric Patients: Symptoms, Outcomes and Preexisting Comorbidities. Clinics, v. 75, 2020-11-30. (15/03756-4, 14/50489-9)

FERREIRA, GABRIELA R. V.; TOMIOKA, RENATO B.; AIKAWA, NADIA E.; LEON, ELAINE P.; MACIEL, GUSTAVO A. R.; SERAFINI, PAULO C.; BARACAT, EDMUND C.; GOLDENSTEIN-SCHAINBERG, CLAUDIA; PEREIRA, ROSA M. R.; BONFA, ELOISA; et al. Ovarian reserve in young juvenile idiopathic arthritis patients. MODERN RHEUMATOLOGY, v. 29, n. 3, p. 447-451, MAY 4 2019. (15/03756-4, 14/14806-0)

BRUNNER, HERMINE I.; HOLLAND, MICHAEL; BERESFORD, MICHAEL W.; ARDOIN, STACY P.; APPENZELLER, SIMONE; SILVA, CLOVIS A.; FLORES, FRANCISCO; GOILAV, BEATRICE; WENDERFER, SCOTT E.; LEVY, DEBORAH M.; et al. American College of Rheumatology Provisional Criteria for Global Flares in Childhood-Onset Systemic Lupus Erythematosus. ARTHRITIS CARE & RESEARCH, v. 70, n. 6, p. 813-822, JUN 2018. (15/03756-4)

ISLABA, ALINE G.; MOTA, LICIA M. H.; RIBEIRO, MARIA CUSTODIA M.; ARABI, TAMIMA M.; CIVIDATTI, GEORGIANA N.; QUEIROZ, LIGIA B.; ANDRADE, DANIELI C.; SAKAMOTO, ANA P.; TRINDADE, VITOR C.; NOVAK, GLAUCIA V.; et al. Childhood-onset systemic lupus erythematosus-related antiphospholipid syndrome: A multicenter study with 1519 patients. AUTOIMMUNITY REVIEWS, v. 19, n. 12, DEC 2020. (15/03756-4)

SILVA, CLOVIS ARTUR; TRINDADE, VITOR CAVALCANTI; DA CRUZ, AMANDA MONTEIRO; BLANCO, BRUNA PACCOLA; VECCHI SANTOS, JOAO FERNANDO; FERRARO, ALEXANDRE ARCHANJO; ODONE-FILHO, VICENTE; TANNURI, UENIS; CARVALHO, WERTHER BRUNOW; CARNEIRO-SAMPAIO, MAGDA; et al. Profile of health professionals who completed a master's, doctoral, or post-doctoral degree in one Brazilian pediatric program. Clinics, v. 75, 2020. (15/03756-4)

SIGNORELLI, FLAVIO; BALBI, GUSTAVO GUIMARAES MOREIRA; BONFA, ELOISA; BORBA, EDUARDO F.; ANDRADE, DANIELI CASTRO DE OLIVEIRA. Avoiding misclassification of thrombotic primary antiphospholipid syndrome as systemic lupus erythematosus (SLE): What are the best-performing SLE classification criteria?. Lupus, v. 30, n. 11, JUL 2021. (15/03756-4)

CLOVIS ARTUR SILVA. REDUÇÃO DA ADERÊNCIA AO TRATAMENTO MEDICAMENTOSO EM CRIANÇAS E ADOLESCENTES COM DOENÇAS REUMÁTICAS AUTOIMUNES. Revista Paulista de Pediatria, v. 37, n. 2, p. 138-139, 2019-06-19. (15/03756-4)

BENATTI, FABIANA B.; MIYAKE, CINTIA N. H.; DANTAS, WAGNER S.; ZAMBELLI, VANESSA O.; SHINJO, SAMUEL K.; PEREIRA, ROSA M. R.; SILVA, MARIA ELIZABETH R.; SA-PINTO, ANA LUCIA; BORBA, EDUARDO; BONFA, ELOISA; et al. Exercise Increases Insulin Sensitivity and Skeletal Muscle AMPK Expression in Systemic Lupus Erythematosus: A Randomized Controlled Trial. FRONTIERS IN IMMUNOLOGY, v. 9, APR 27 2018. (11/08302-0, 15/03756-4, 11/24093-2, 17/02546-1)

FERREIRA, JULIANA C. O. A.; TRINDADE, VITOR C.; ESPADA, GRACIELA; MOREL, ZOILO; BONFA, ELOISA; MAGALHAES, CLAUDIA S.; SILVA, CLOVIS ARTUR. Epidemiology and management practices for childhood-onset systemic lupus erythematosus patients: a survey in Latin America. CLINICAL RHEUMATOLOGY, v. 37, n. 12, p. 3299-3307, DEC 2018. (15/03756-4)

BALBI, VERENA A.; MONTENEGRO, BARBARA; PITTA, ANA C.; SCHMIDT, ANA R.; FARHAT, SYLVIA C.; COELHO, LAILA P.; FERREIRA, JULIANA C. O.; PEREIRA, ROSA M. R.; TERRERI, MARIA T.; SAAD-MAGALHAES, CLAUDIA; et al. Autoimmune hepatitis in 847 childhood- onset systemic lupus erythematosus population: a multicentric cohort study. ADVANCES IN RHEUMATOLOGY, v. 58, DEC 13 2018. (15/03756-4)

SHIMABUCO, ANDREA Y.; GONCALVES, CELIO R.; MORAES, JULIO C. B.; WAISBERG, MARIANA G.; RIBEIRO, ANA CRISTINA DE M.; SAMPAIO-BARROS, PERCIVAL D.; GOLDENSTEIN-SCHAINBERG, CLAUDIA; BONFA, ELOISA; SAAD, CARLA G. S.. Factors associated with ASDAS remission in a long-term study of ankylosing spondylitis patients under tumor necrosis factor inhibitors. ADVANCES IN RHEUMATOLOGY, v. 58, DEC 4 2018. (15/03756-4)

BUSCATTI, IZABEL M.; ABRAO, HENRIQUE M.; KOZU, KATIA; MARQUES, VICTOR L. S.; GOMES, ROBERTA C.; SALLUM, ADRIANA M. E.; SILVA, CLOVIS A.. Characterization of scrotal involvement in children and adolescents with IgA vasculitis. ADVANCES IN RHEUMATOLOGY, v. 58, NOV 3 2018. (15/03756-4)

SILVA, CLOVIS A.; TERRERI, MARIA T.; BONFA, ELOISA; SAAD-MAGALHAES, CLAUDIA. Pediatric rheumatic disease patients: time to extend the age limit of adolescence?. ADVANCES IN RHEUMATOLOGY, v. 58, SEP 18 2018. (15/03756-4)

DINIS, VALQUIRIA G.; VIANA, VILMA T.; LEON, ELAINE P.; SILVA, CLOVIS A.; SAAD, CARLA G.; MORAES, JULIO C.; BONFA, ELOISA S.; MEDEIROS-RIBEIRO, ANA C.. Abatacept induced long-term non-progressive reduction in gamma-globulins and autoantibodies: dissociation from disease activity control. CLINICAL RHEUMATOLOGY, v. 39, n. 6, p. 1747-1755, JUN 2020. (15/03756-4)

CLAUDINO FORMIGA, FRANCISCO FELLIPE; SILVA, CLOVIS ARTUR; PEDROSA, TATIANA DO NASCIMENTO; AIKAWA, NADIA EMI; PASOTO, SANDRA GOFINET; GARCIA, CRISTIANA COUTO; VIDAL CAPAO, ARTUR SILVA; DE OLIVEIRA MARTINS, VICTOR ADRIANO; TONACIO DE PROENCA, ADRIANA CORACINI; FULLER, RICARDO; et al. Influenza A/Singapore (H3N2) component vaccine in systemic lupus erythematosus: A distinct pattern of immunogenicity. Lupus, v. 30, n. 12, AUG 2021. (18/09937-9, 17/14352-7, 10/10749-0, 15/03756-4, 18/16162-3)

BERTOGLIO, ISABELA MARIA; DE LUCENA VALIM, JULIANA MIRANDA; DAFFRE, DANIELLE; AIKAWA, NADIA EMI; SILVA, CLOVIS ARTUR; BONFA, ELOISA; UGOLINI-LOPES, MICHELLE REMIAO. Poor Prognosis of COVID-19 Acute Respiratory Distress Syndrome in Lupus Erythematosus: Nationwide Cross-Sectional Population Study Of 252 119 Patients. ACR OPEN RHEUMATOLOGY, AUG 2021. (15/03756-4)

NEVES YUKI, EMILY FIGUEIREDO; SILVA, CLOVIS A.; AIKAWA, NADIA E.; ROMITI, RICARDO; HEISE, CARLOS OTTO; BONFA, ELOISA; PASOTO, SANDRA GOFINET. Thalidomide and Lenalidomide for Refractory Systemic/Cutaneous Lupus Erythematosus Treatment A Narrative Review of Literature for Clinical Practice. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, v. 27, n. 6, p. 248-259, SEP 2021. (15/03756-4)

ASTLEY, CAMILLA; PINTO, ANA JESSICA; BONFA, ELOISA; DA SILVA, CLOVIS ARTUR ALMEIDA; GUALANO, BRUNO. Gaps on rheumatologists' knowledge of physical activity. CLINICAL RHEUMATOLOGY, v. 40, n. 7, JAN 2021. (15/26937-4, 17/13552-2, 15/03756-4)

ZANETTI, CAIO B.; PEDROSA, TATIANA; KUPA, LEONARD DE V. K.; AIKAWA, NADIA E.; BORBA, EDUARDO F.; VENDRAMINI, MARGARETE B. G.; SILVA, CLOVIS A.; PASOTO, SANDRA G.; BONFA, ELOISA. Hydroxychloroquine blood levels in stable lupus nephritis under low dose (2-3 mg/kg/day): 12-month prospective randomized controlled trial. CLINICAL RHEUMATOLOGY, v. 40, n. 7, JAN 2021. (17/14352-7, 19/17272-0, 15/03756-4, 17/03983-6)

USUBA, FANY SOLANGE; DE MEDEIROS-RIBEIRO, ANA CRISTINA; NOVAES, PRISCILA; AIKAWA, NADIA EMI; BONFIGLIOLI, KARINA; SANTO, RUTH MIYUKI; BONFA, ELOISA; ALVES, MILTON RUIZ. Dry eye in rheumatoid arthritis patients under TNF-inhibitors: conjunctival goblet cell as an early ocular biomarker. SCIENTIFIC REPORTS, v. 10, n. 1, AUG 20 2020. (15/03756-4)

ASTLEY, CAMILLA; CLEMENTE, GLEICE; TERRERI, MARIA TERESA; CARNEIRO, CAMILA G.; LIMA, MARCOS S.; BUCHPIGUEL, CARLOS ALBERTO; LEAO FILHO, HILTON; PINTO, ANA LUCIA DE SA; SILVA, CLOVIS ARTUR; ARRUDA CAMPOS, LUCIA MARIA; et al. Home-Based Exercise Training in Childhood-Onset Takayasu Arteritis: A Multicenter, Randomized, Controlled Trial. FRONTIERS IN IMMUNOLOGY, v. 12, JUL 28 2021. (15/03756-4, 17/07358-9, 17/13552-2)

REINAN T. CAMPOS; LIVIA LINDOSO; RENAN A. DE SOUSA; ALBERTO C. HELITO; BIANCA P. IHARA; CLAUDIA A.A. STRABELLI; LEVI M.V. PARADELAS; BEATRIZ O.L. CARNEIRO; MARIA PAULA R. CARDOSO; JEAN PAULO V. DE SOUZA; et al. Emotional, hyperactivity and inattention problems in adolescents with immunocompromising chronic diseases during the COVID-19 pandemic. Clinics, v. 78, 2023-03-17. (15/03756-4)

NOVELLINO, RENATA SOARES; CHALOM, MARC YVES; ROMANO, PASCHOALINA; REZENDE EBNER, PERSIO DE ALMEIDA; SERAPHIM, JULIA CELESTINO; SILVA DO AMARAL, ANA CAROLINA; COELHO DUARTE, NILO JOSE; PEDROSA, TATIANA DO NASCIMENTO; NEVES YUKI, EMILY FIGUEIREDO; AIKAWA, NADIA EMI; et al. Thalidomide measurement in plasma and dried plasma spot by SPE combined with UHPLC-MS/MS for therapeutic drug monitoring. BIOANALYSIS, v. 14, n. 15, p. 12-pg., 2022-09-20. (19/17272-0, 17/03983-6, 19/21211-6, 15/03756-4)

HELITO, ALBERTO C.; LINDOSO, LIVIA; SIECZKOWSKA, SOFIA M.; ASTLEY, CAMILLA; QUEIROZ, LIGIA B.; ROSE, NATALIA; SANTOS, CLAUDIA RENATA P.; BOLZAN, THALIS; PERALTA, RITA MARIA I. A.; FRANCO, RUTH R.; et al. Poor Sleep quality and health-related quality of life impact in adolescents with and without chronic immunosuppressive conditions during COVID-19 quarantine. Clinics, v. 76, 2021. (15/03756-4)

ISLABAO, ALINE GARCIA; TRINDADE, VITOR CAVALCANTI; DA MOTA, LICIA MARIA HENRIQUE; ANDRADE, DANIELI CASTRO OLIVEIRA; SILVA, CLOVIS ARTUR. Managing Antiphospholipid Syndrome in Children and Adolescents: Current and Future Prospects. PEDIATRIC DRUGS, v. 24, n. 1, DEC 2021. (15/03756-4)

GUALANO, BRUNO; SIECZKOWSKA, SOFIA M.; LEMES, ITALO RIBEIRO; DA SILVA, RAFAEL PIRES; PINTO, ANA J.; MAZZOLANI, BRUNA C.; SMAIRA, FABIANA I.; AIKAWA, NADIA E.; KUPA, LEONARD V. K.; PASOTO, SANDRA G.; et al. Physical Activity: A Strategy to Improve Antibody Response to a SARS-CoV-2 Vaccine Booster Dose in Patients With Autoimmune Rheumatic Diseases. JOURNAL OF PHYSICAL ACTIVITY & HEALTH, v. 20, n. 4, p. 6-pg., 2023-03-03. (17/23688-9, 19/14820-6, 17/13552-2, 15/26937-4, 15/03756-4, 20/04877-8, 19/14819-8, 19/15231-4)

MUNHOZ, GABRIELA A.; AIKAWA, NADIA E.; SILVA, CLOVIS A.; PASOTO, SANDRA G.; PEDROSA, TATIANA N.; SEGURO, LUCIANA P. C.; BONFA, ELOISA; BORBA, EDUARDO F.. Short-term Accrual 2019 European League Against Rheumatism/American College of Rheumatology Domains and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage in Lupus Patients With and Without Nephritis at Disease Onset. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, v. 29, n. 4, p. 6-pg., 2023-06-01. (17/14352-7, 18/16162-3, 15/03756-4)

ASTLEY, CAMILLA; LEAL, GABRIELA NUNES; GIL, SAULO; SUGUITA, PRISCILA; FINK, THAIS; BAIN, VERA; PEREIRA, MARIA FERNANDA BADUE; MARQUES, HELOISA HELENA; SIECZKOWSKA, SOFIA; PRADO, DANILO; et al. Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study. CHILDREN-BASEL, v. 10, n. 5, p. 14-pg., 2023-05-16. (17/13552-2, 21/02742-0, 19/15231-4, 15/03756-4)

SOUSA, BRAIAN LUCAS AGUIAR; SILVA, CLOVIS ARTUR; FERRARO, ALEXANDRE ARCHANJO. An update on the epidemiology of pediatric COVID-19 in Brazil. Revista Paulista de Pediatria, v. 40, p. 5-pg., 2022-01-01. (15/03756-4)

ESTEVES, GABRIEL P.; MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; SANTO ANDRE, HELOISA C.; IRAHA, AMANDA YURI; ASTLEY, CAMILLA; MARQUES, ISABELA GOUVEIA; AMARANTE, MILLA CORDEIRO; REZENDE, NATHALIA SAFFIOTI; SIECZKOWSKA, SOFIA MENDES; et al. Food consumption based on processing level (according to Nova system) during the COVID-19 pandemic among adolescents with immunocompromised conditions: a case-control study. FRONTIERS IN NUTRITION, v. 10, p. 9-pg., 2023-05-16. (21/02742-0, 19/14820-6, 17/13552-2, 15/26937-4, 20/07860-9, 15/03756-4, 20/02741-1, 19/20814-9, 16/00006-7, 19/14819-8, 19/15231-4)

SMAIRA, FABIANA INFANTE; MAZZOLANI, BRUNA CARUSO; LEMES, ITALO RIBEIRO; DA SILVA, RAFAEL PIRES; PINTO, ANA J.; SIECZKOWSKA, SOFIA M.; AIKAWA, NADIA E.; PASOTO, SANDRA G.; MEDEIROS-RIBEIRO, ANA C.; SAAD, CARLA G. S.; et al. No Associations Between Physical Activity and Immunogenicity in SARS-CoV-2 Seropositive Patients With Autoimmune Rheumatic Diseases Prior to and After Vaccination. JOURNAL OF PHYSICAL ACTIVITY & HEALTH, v. N/A, p. 4-pg., 2023-06-08. (17/23688-9, 19/14820-6, 17/13552-2, 15/26937-4, 15/03756-4, 20/04877-8, 19/14819-8, 19/15231-4)

BALMANT, BIANCA D.; TORRINHAS, RAQUEL S.; ROCHA, ILANNA M.; FONSECA, DANIELLE C.; FORMIGA, FRANCISCO F. C.; BONFA, ELOISA S. D. O.; BORBA, EDUARDO F.; WAITZBERG, DAN L.. SARS-CoV-2 infection, gut dysbiosis, and heterogeneous clinical results of hydroxychloroquine on COVID-19 therapy-Is there a link?. NUTRITION, v. 85, p. 3-pg., 2021-02-02. (18/16162-3, 15/03756-4)

NADIA EMI AIKAWA; EDUARDO FERREIRA BORBA; VERENA ANDRADE BALBI; ADRIANA MALUF ELIAS SALLUM; IZABEL MANTOVANI BUSCATTI; LUCIA MARIA ARRUDA CAMPOS; KÁTIA TOMIE KOZU; CRISTIANA COUTO GARCIA; ARTUR SILVA VIDAL CAPÃO; ADRIANA CORACINI TONACIO DE PROENÇA; et al. Safety and immunogenicity of influenza A(H3N2) component vaccine in juvenile systemic lupus erythematosus. ADVANCES IN RHEUMATOLOGY, v. 63, 2023-12-18. (17/14352-7, 18/16162-3, 15/03756-4, 10/10749-0)

PRADO, L. L.; GONCALVES, C. R.; VIANA, V. T.; SAAD, C. G. S.; BONFA, E.. Anti-alpha-enolase antibodies in Behcet's disease: a marker of mucocutaneous and articular disease activity?. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v. 36, n. 6, p. 5-pg., 2018-01-01. (15/03756-4)