Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy

• Grant number: 15/03756-4
• Support Opportunities: Research Projects - Thematic Grants
• Start date: March 01, 2017
• End date: February 28, 2023
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Eloisa Silva Dutra de Oliveira Bonfá
• Grantee: Eloisa Silva Dutra de Oliveira Bonfá
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Pesquisadores principais: Clovis Artur Almeida da Silva ; Nádia Emi Aikawa ; Sandra Gofinet Pasoto
• Associated researchers: Alberto José da Silva Duarte ; Ana Cristina de Medeiros Ribeiro ; Carla Gonçalves Schahin Saad ; Eduardo Ferreira Borba Neto ; Esper Georges Kallás ; Gilberto de Nucci ; Luis Felipe das Chagas e Silva de Carvalho ; Pedro Carlos Carricondo ; Rosa Maria Rodrigues Pereira ; Valdemir Melechco Carvalho ; Vilma dos Santos Trindade Viana
• Associated research grant(s): 17/03983-6 - Liquid chromatography coupled to mass spectrometry (2015/03756-4), AP.EMU
• Associated scholarship(s): 22/09565-0 - Post-Covid-19 syndrome in patients with autoimmune rheumatological diseases, BP.IC; 22/09566-6 - Immunogenicity and safety of booster doses of CoronaVac vaccine in patients with autoimmune rheumatologic diseases patients, BP.IC; 21/08455-3 - Immunogenicity and safety of Coronavac vaccine in patients with autoimmune rheumatologic diseases: primary Sjörgren syndrome, BP.IC; + associated scholarships 21/06615-3 - Immunogenicity and safety of CoronaVac vaccine in patients with autoimmune rheumatologic diseases: Juvenile systemic erythemesus lupus, BP.IC; 21/06616-0 - Validation of dry sample devices (Dried Blood Spot) for the therapeutic monitoring of hydroxychloroquine in rheumatic diseases, BP.IC; 21/06613-0 - Immunogenicity and safety of CoronaVac vaccine in patients with autoimmune rheumatic diseases: rheumatoid arthritis, BP.IC; 20/11677-5 - Analysis of the immune profile of saliva and serum of patients with primary Sjögren's Syndrome, BP.IC; 20/09367-8 - Analysis of blood hydroxychlorochine levels in patients with primary Sjogren Syndrome and possible correlation with the disease activity, BP.DD; 20/02625-1 - Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy, BP.TT; 19/21211-6 - Salivary hydroxychloroquine levels: relevance in juvenile systemic lupus erythematosus (JSLE) disease activity and renal disease activity in adult systemic lupus erythematosus, BP.IC; 19/21173-7 - Evaluation of the treatment of cutaneous lupus erythematosus with thalidomide: clinical, laboratory and histological factors associated with clinical response and adverse effects, BP.IC; 19/17272-0 - Relevance of monitoring blood levels compared to salivar levels of drugs used in rheumatic autoimmune diseases: adherence and understanding the possible underlying mechanisms involved in effectiveness and in adverse effects, BP.PD; 18/21594-0 - Analysis of the immune profile of saliva and serum of patients with primary Sjögren's syndrome, BP.IC; 18/09937-9 - Analysis of the immune profile of saliva and serum of patients with primary Sjogren's Syndrome, BP.DD; 17/14352-7 - Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy, BP.PD; 17/11644-7 - Blood and salivary levels of hydroxychloroquine: relevance in juvenile systemic lupus erythematosus disease (JSLE), in kidney disease in adult SLE activity and in alpha-interferon / TNF production by plasmacytoid dendritic cells, BP.TT; 17/11516-9 - Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy, BP.PD; 17/11854-1 - Assessment of serum levels of anti-tumor necrosis factor (anti-TNF) and anti-drug antibodies (ADA) in patients with chronic inflammatory arthritis: ankylosing spondylitis and psoriatic arthritis, BP.IC; 17/07966-9 - Assessment of serum levels of anti-tumor necrosis factor (anti-TNF) and anti-drug antibodies (ADA) in patients with chronic inflammatory arthritis: ankylosing spondylitis and psoriatic arthritis, BP.IC; 17/07964-6 - Evaluation of serum levels of anti-tumor necrosis factor (antiTNF) and anti-drug (ada) antibodies in patients with chronic inflammatory arthritis - juvenile idiopathic arthritis, BP.IC - associated scholarships

Abstract

No drug treatment is completely free of risk and lack of response, adverse events and poor adherence may affect its effectiveness. There is also a large inter-individual variability in response to treatments with regard to efficacy and toxicity, and for many drugs, there is also a period of weeks to months to establish its efficacy. Within this context, this project aims to evaluate the importance of monitoring blood levels and salivary drug used in rheumatic autoimmune diseases in the monitoring of adherence to therapy. In addition, this project intends to use the monitoring of drug levels, based on pharmacokinetic studies and pharmacokinetics/pharmacodynamics modeling, to broaden the understanding of the possible cellular, tissue and immunological mechanisms involved in efficacy and adverse effects of these drugs with the prospect of reducing the damage and maintain therapeutic efficacy. The high-performance liquid chromatography (HPLC) coupled to mass spectrometry, which will be used to evaluate hydroxychloroquine, thalidomide, glucocorticoids, is considered the gold standard technology to qualitative and quantitative analysis of drugs in blood and its comparison with the dosage in the saliva is an improvement in simplification of the process. The implementation of this methodology dedicated to research in our center, with the necessary training of human resources, will enable the standardization and availability of this advanced technology to other muldisciplinary projects in various areas of science. For biological agents the focus will be on the understanding the loss of efficacy and the possible role of anti-TNF antibodies using ELISA capture methodology.This thematic project will be divided into four sections with their respective sub-projects according to the medications that will be studied: hydroxychloroquine, thalidomide, biologic agents and glucocorticoids. (AU)

Scientific publications

(126)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PINTO, ANA JESSICA; DUNSTAN, DAVID W.; OWEN, NEVILLE; BONFA, ELOISA; GUALANO, BRUNO. Combating physical inactivity during the COVID-19 pandemic. Nature Reviews Rheumatology, APR 2020. (15/26937-4, 17/13552-2, 18/19418-9, 15/03756-4)

LOURENCO, DANIELA M. R.; ARAUJO, DANIEL B.; AIKAWA, NADIA E.; YAMAKAMI, LUCAS Y. S.; BORBA, EDUARDO F.; MACIEL, GUSTAVO A. R.; SOARES-JUNIOR, JOSE M.; BARACAT, EDMUND C.; PEREIRA, ROSA M. R.; BONFA, ELOISA; et al. Adrenal steroidogenesis and ovarian reserve in adult childhood-onset systemic lupus erytematosus patients. CLINICAL RHEUMATOLOGY, MAR 2021. (15/03756-4)

THAIS T. FINK; HELOISA H.S. MARQUES; BRUNO GUALANO; LIVIA LINDOSO; VERA BAIN; CAMILLA ASTLEY; FERNANDA MARTINS; DENISE MATHEUS; OLIVIA M. MATSUO; PRISCILA SUGUITA; et al. Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital. Clinics, v. 76, 2021-11-26. (13/07914-8, 15/03756-4)

BRUNELLI, JULIANA BARBOSA; SCHMIDT, ANA RENATA; SALLUM, ADRIANA MALUF ELIAS; GOLDENSTEIN-SCHAINBERG, CLAUDIA; BONFA, ELOISA; SILVA, CLOVIS A.; AIKAWA, NADIA EMI. High rate of serious infection in juvenile idiopathic arthritis patients under biologic therapy in a real-life setting. MODERN RHEUMATOLOGY, v. 28, n. 2, p. 264-270, 2018. (14/14806-0, 15/03756-4)

BUSCATTI, IZABEL M.; CASELLA, BEATRIZ B.; AIKAWA, NADIA E.; WATANABE, ANDREA; FARHAT, SYLVIA C. L.; CAMPOS, LUCIA M. A.; SILVA, CLOVIS ARTUR. Henoch-Schonlein purpura nephritis: initial risk factors and outcomes in a Latin American tertiary center. CLINICAL RHEUMATOLOGY, v. 37, n. 5, p. 1319-1324, MAY 2018. (15/03756-4)

TISEO, B. C.; BONFA, E.; BORBA, E. F.; MUNHOZ, G. A.; WOOD, G. J. A.; SROUGI, M.; SILVA, C. A.; COCUZZA, M.. Complete urological evaluation including sperm DNA fragmentation in male systemic lupus erythematosus patients. Lupus, v. 28, n. 1, p. 59-65, JAN 2019. (15/03756-4, 14/14806-0)

GUALANO, BRUNO; BONFA, ELOISA; PEREIRA, ROSA M. R.; SILVA, CLOVIS A.. Physical activity for paediatric rheumatic diseases: standing up against old paradigms. Nature Reviews Rheumatology, v. 13, n. 6, p. 368-379, JUN 2017. (15/03756-4)

PINTO, ANA JESSICA; ROSCHEL, HAMILTON; DE SA PINTO, ANA LUCIA; LIMA, FERNANDA RODRIGUES; RODRIGUES PEREIRA, ROSA MARIA; SILVA, CLOVIS ARTUR; BONFA, ELOISA; GUALANO, BRUNO. Physical inactivity and sedentary behavior: Overlooked risk factors in autoimmune rheumatic diseases?. AUTOIMMUNITY REVIEWS, v. 16, n. 7, p. 667-674, JUL 2017. (15/26937-4, 15/03756-4)

NOVAK, V, G.; MOLINARI, B. C.; FERREIRA, J. C.; SAKAMOTO, A. P.; TERRERI, M. T.; PEREIRA, R. M. R.; SAAD-MAGALHAES, C.; AIKAWA, N. E.; CAMPOS, L. M.; LEN, C. A.; et al. Characteristics of 1555 childhood-onset lupus in three groups based on distinct time intervals to disease diagnosis: a Brazilian multicenter study. Lupus, v. 27, n. 10, p. 1712-1717, SEP 2018. (15/03756-4)

TRINDADE, VITOR CAVALCANTI; CARNEIRO-SAMPAIO, MAGDA; BONFA, ELOISA; SILVA, CLOVIS ARTUR. An Update on the Management of Childhood-Onset Systemic Lupus Erythematosus. PEDIATRIC DRUGS, v. 23, n. 4, p. 331-347, JUL 2021. (15/03756-4)

MENDES, CRISTIANE; VIANA, VILMA S. T.; PASOTO, SANDRA G.; LEON, ELAINE P.; BONFA, ELOISA; SAMPAIO-BARROS, PERCIVAL D.. Clinical and laboratory features of African-Brazilian patients with systemic sclerosis. CLINICAL RHEUMATOLOGY, v. 39, n. 1, p. 9-17, JAN 2020. (15/03756-4)

TOMIOKA, RENATO B.; FERREIRA, GABRIELA R. V.; AIKAWA, NADIA E.; MACIEL, GUSTAVO A. R.; SERAFINI, PAULO C.; SALLUM, ADRIANA M.; CAMPOS, LUCIA M. A.; GOLDESTEIN-SCHAINBERG, CLAUDIA; BONFA, ELOISA; SILVA, CLOVIS A.. Non-steroidal anti-inflammatory drug induces luteinized unruptured follicle syndrome in young female juvenile idiopathic arthritis patients. CLINICAL RHEUMATOLOGY, v. 37, n. 10, p. 2869-2873, OCT 2018. (15/03756-4, 14/14806-0)

AIKAWA, NADIA EMI; KANDA KUPA, LEONARD DE VINCI; MEDEIROS-RIBEIRO, ANA CRISTINA; SCHAHIN SAAD, CARLA GONCALVES; NEVES YUKI, EMILY FIGUEIREDO; PASOTO, SANDRA GOFINET; ROJO, PRISCILA TAGLIAFERRO; RODRIGUES PEREIRA, ROSA MARIA; SHINJO, SAMUEL KATSUYUKI; SAMPAIO-BARROS, PERCIVAL DEGRAVA; et al. Increment of immunogenicity after third dose of a homologous inactivated SARS-CoV-2 vaccine in a large population of patients with autoimmune rheumatic diseases. ANNALS OF THE RHEUMATIC DISEASES, v. 81, n. 7, p. 8-pg., 2022-03-10. (20/09367-8, 19/17272-0, 15/03756-4, 18/09937-9)

MEDEIROS-RIBEIRO, ANA CRISTINA; BONFIGLIOLI, KARINA ROSSI; DOMICIANO, DIOGO SOUZA; SHIMABUCO, ANDREA YUKIE; DA SILVA, HENRIQUE CARRICO; SAAD, CARLA G. S.; YUKI, EMILY FIGUEIREDO NEVES; PASOTO, SANDRA GOFINET; RENNER ARAUJO, CARLO SCOGNAMIGLIO; NAKAI, TATIANE LIE; et al. Distinct impact of DMARD combination and monotherapy in immunogenicity of an inactivated SARS-CoV-2 vaccine in rheumatoid arthritis. ANNALS OF THE RHEUMATIC DISEASES, v. 81, n. 5, p. 10-pg., 2022-02-07. (21/06613-0, 17/14352-7, 19/17272-0, 15/03756-4)

DINIZ, MARIA DE FATIMA RODRIGUES; KOZU, KATIA TOMIE; ELIAS, ADRIANA MALUF; LIANZA, ALESSANDRO CAVALCANTI; SAWAMURA, KAREN SAORI SHIRAISHI; MENEZES, CAROLINA ROCHA BRITO; FERREIRA, JULIANA CAIRES DE OLIVEIRA ACHILI; SILVA, CLOVIS ARTUR; LEAL, GABRIELA NUNES. Echocardiographic study of juvenile dermatomyositis patients: new insights from speckle-tracking-derived strain. CLINICAL RHEUMATOLOGY, v. 40, n. 4, p. 1497-1505, APR 2021. (15/03756-4)

GABRIEL F. RAMOS; VANESSA P. RIBEIRO; MARIANA P. MERCADANTE; MAIRA P. RIBEIRO; ARTUR F. DELGADO; SYLVIA C.L. FARHAT; MARTA M. LEAL; HELOISA H. MARQUES; VICENTE ODONE-FILHO; UENIS TANNURI; et al. Mortalidade entre adolescentes e adultos jovens com doenças crônicas durante 16 anos: estudo em um hospital terciário da América Latina. Jornal de Pediatria, v. 95, n. 6, p. 667-673, 2019-11-25. (15/03756-4)

GERALDO FILHO BUSATTO; CLOVIS ARTUR SILVA; ANTONIO JOSÉ RODRIGUES PEREIRA; ELOISA BONFÁ; TARCÍSIO ELOY PESSOA DE BARROS-FILHO. Scientific legacy of COVID-19 at the FMUSP-HC academic health system: current status and implications for the future. Clinics, v. 76, 2021-12-08. (15/03756-4)

SIGNORELLI, FLAVIO; BALBI, GUSTAVO GUIMARAES MOREIRA; AIKAWA, NADIA E.; SILVA, CLOVIS A.; KUPA, LEONARD DE VINCI KANDA; MEDEIROS-RIBEIRO, ANA C.; YUKI, EMILY F. N.; PASOTO, SANDRA G.; SAAD, CARLA G. S.; BORBA, EDUARDO F.; et al. Immunogenicity, safety, and antiphospholipid antibodies after SARS-CoV-2 vaccine in patients with primary antiphospholipid syndrome. Lupus, v. 31, n. 8, p. 11-pg., 2022-05-20. (19/17272-0, 15/03756-4)

SAKAMOTO, ANA P.; SILVA, CLOVIS A.; ISLABAO, ALINE G.; NOVAK, GLAUCIA, V; MOLINARI, BEATRIZ; NOGUEIRA, PAULO K.; PEREIRA, ROSA M. R.; SAAD-MAGALHAES, CLAUDIA; CLEMENTE, GLEICE; PIOTTO, DANIELA P.; et al. Chronic kidney disease in patients with childhood-onset systemic lupus erythematosus. Pediatric Nephrology, v. N/A, p. 12-pg., 2022-11-21. (15/03756-4)

CLOVIS ARTUR SILVA; LEONARD DE VINCI KANDA KUPA; ANA CRISTINA MEDEIROS-RIBEIRO; SANDRA GOFINET PASOTO; CARLA GONÇALVES SCHAHIN SAAD; EMILY FIGUEIREDO NEVES YUKI; JOAQUIM IVO VASQUES DANTAS LANDIM; VICTOR HUGO FERREIRA E LÉDA; LUISA SACCHI DE CAMARGO CORREIA; ARTUR FONSECA SARTORI; et al. Post-acute COVID-19 in three doses vaccinated autoimmune rheumatic diseases patients: frequency and pattern of this condition. ADVANCES IN RHEUMATOLOGY, v. 63, 2023-09-01. (22/09565-0, 22/09566-6, 19/17272-0, 19/21173-7, 15/03756-4, 21/08455-3, 18/09937-9)

BONFA, ELOISA; GOSSEC, LAURE; ISENBERG, DAVID A.; LI, ZHANGUO; RAYCHAUDHURI, SOUMYA. How COVID-19 is changing rheumatology clinical practice. Nature Reviews Rheumatology, v. 17, n. 1, p. 5-pg., 2020-11-02. (15/03756-4)

SAKAMOTO, ANA P.; SILVA, CLOVIS A.; PITA, ANA C.; TRINDADE, VITOR C.; ISLABAO, ALINE G.; FIOROT, FERNANDA J.; LOPES, SANDRA R. M.; PEREIRA, ROSA M. R.; SAAD-MAGALHAES, CLAUDIA; RUSSO, GLEICE C. S.; et al. Risk factors for mortality in 1528 Brazilian childhood-onset systemic lupus erythematosus patients. Lupus, v. N/A, p. 10-pg., 2023-04-18. (15/03756-4)

PASOTO, SANDRA GOFINET; BORBA, EDUARDO FERREIRA; FORMIGA, FRANCISCO FELLIPE CLAUDINO; DO NASCIMENTO PEDROSA, TATIANA; AIKAWA, NADIA EMI; DE SIQUEIRA, MARILDA AGUDO MENDONCA TEIXEIRA; CAPAO, ARTUR SILVA VIDAL; DE PROENCA, ADRIANA CORACINI TONACIO; FULLER, RICARDO; YUKI, EMILY FIGUEIREDO NEVES; et al. Robust immunogenicity to the H3N2 component of influenza A vaccine in primary Sjogren syndrome. CLINICAL RHEUMATOLOGY, v. 42, n. 9, p. 7-pg., 2023-06-12. (17/14352-7, 18/16162-3, 15/03756-4)

PINTO, ANA JESSICA; DUNSTAN, DAVID W.; OWEN, NEVILLE; BONFA, ELOISA; GUALANO, BRUNO. Combating physical inactivity during the COVID-19 pandemic. Nature Reviews Rheumatology, v. 16, n. 7, p. 2-pg., 2020-04-30. (17/13552-2, 18/19418-9, 15/26937-4, 15/03756-4)

BRUNELLI, JULIANA BARBOSA; SILVA, CLOVIS ALMEIDA; PASOTO, SANDRA GOFINET; SCHAHIN SAA, CARLA GONCALVES; KOZU, KATIA TOMIE; GOLDENSTEIN-SCHAINBERG, CLAUDIA; LEON, ELAINE PIRES; VENDRAMINI, MARGARETE B. G.; FONTOURA, NICOLE; BONFA, ELOISA; et al. Anti-adalimumab antibodies kinetics: an early guide for juvenile idiopathic arthritis (JIA) switching. CLINICAL RHEUMATOLOGY, v. 39, n. 2, p. 7-pg., 2019-11-09. (15/03756-4)

YUKI, EMILY F. N.; BORBA, EDUARDO F.; PASOTO, SANDRA G.; SEGURO, LUCIANA P.; LOPES, MICHELLE; SAAD, CARLA G. S.; MEDEIROS-RIBEIRO, ANA CRISTINA; SILVA, CLOVIS A.; DE ANDRADE, DANIELI C. O.; KUPA, LEONARD DE VINCI K.; et al. Impact of Distinct Therapies on Antibody Response to SARS-CoV-2 Vaccine in Systemic Lupus Erythematosus. ARTHRITIS CARE & RESEARCH, v. 74, n. 4, p. 10-pg., 2022-03-04. (15/03756-4, 17/14352-7, 19/17272-0, 21/06615-3)

SAMPAIO-BARROS, PERCIVAL DEGRAVA; MEDEIROS-RIBEIRO, ANA CRISTINA; LUPPINO-ASSAD, ANA PAULA; MIOSSI, RENATA; DA SILVA, HENRIQUE CARRICO; YUKI, EMILY F. V. N.; PASOTO, SANDRA G.; SAAD, CARLA G. S.; SILVA, CLOVIS A.; KUPA, LEONARD V. K.; et al. SARS-CoV-2 vaccine in patients with systemic sclerosis: impact of disease subtype and therapy. RHEUMATOLOGY, v. 61, n. SI2, p. 6-pg., 2021-12-11. (15/03756-4, 19/17272-0)

AIKAWA, NADIA E.; KUPA, LEONARD V. K.; SILVA, CLOVIS A.; SAAD, CARLA G. S.; PASOTO, SANDRA G.; YUKI, EMILY F. N.; FUSCO, SOLANGE R. G.; SHINJO, SAMUEL K.; ANDRADE, DANIELI C. O.; SAMPAIO-BARROS, PERCIVAL D.; et al. Strong response after fourth dose of mRNA COVID-19 vaccine in autoimmune rheumatic diseases patients with poor response to inactivated vaccine. RHEUMATOLOGY, v. N/A, p. 6-pg., 2022-05-26. (15/03756-4, 19/17272-0)

LANG, MARIA G.; VINAGRE, CARMEN G. C.; BONFA, ELOISA; FREITAS, FATIMA R.; PASOTO, SANDRA G.; BRITO, TATIANE S.; SEGURO, LUCIANA P. C.; MARANHAO, RAUL C.; BORBA, EDUARDO F.. Hydroxychloroquine increased cholesterol transfer to high-density lipoprotein in systemic lupus erythematosus: A possible mechanism for the reversal of atherosclerosis in the disease. Lupus, v. 31, n. 6, p. 7-pg., 2022-03-25. (15/03756-4, 17/14352-7, 14/03742-0)

PALMEIRA, PATRICIA; BARBUTO, JOSE PRIME ALEXANDRE M.; SILVA, CLOVIS ARTUR A.; CARNEIRO-SAMPAIO, MAGDA. Why is SARS-CoV-2 infection milder among children?. Clinics, v. 75, p. 5-pg., 2020-01-01. (15/03756-4, 14/50489-9)

LIANZA, ALESSANDRO C.; LEAL, GABRIELA N.; AIKAWA, NADIA E.; KOZU, KATIA T.; DINIZ, MARIA DE FATIMA R.; SAWAMURA, KAREN S. S.; MENEZES, CAROLINA R. B.; MARTINS, CAMILA LINO; CAMPOS, LUCIA M.; ELIAS, ADRIANA M.; et al. Heart function in juvenile idiopathic arthritis patients: A biventricular two-dimensional speckle-tracking echocardiography study. MODERN RHEUMATOLOGY, v. 32, n. 6, p. 7-pg., 2021-10-06. (15/03756-4)

CLOVIS ARTUR SILVA; LÍGIA BRUNI QUEIROZ; CLAUDIA DE BRITO FONSECA; LUÍS EDUARDO VARGAS DA SILVA; BENITO LOURENÇO; HELOISA HELENA SOUSA MARQUES. Spotlight for healthy adolescents and adolescents with preexisting chronic diseases during the COVID-19 pandemic. Clinics, v. 75, 2020-05-08. (15/03756-4)

HOLLAND, MICHAEL J.; BERESFORD, MICHAEL W.; FELDMAN, BRIAN M.; HUGGINS, JENNIFER; NORAMBUENA, XIMENA; SILVA, CLOVIS A.; SUSIC, GORDANA; SZTAJNBOK, FLAVIO; UZIEL, YOSEF; APPENZELLER, SIMONE; et al. Measuring Disease Damage and Its Severity in Childhood-Onset Systemic Lupus Erythematosus. ARTHRITIS CARE & RESEARCH, v. 70, n. 11, p. 1621-1629, NOV 2018. (15/03756-4)

LOURENCO, DANIELA M. R.; ARAUJO, DANIEL B.; AIKAWA, NADIA E.; YAMAKAMI, LUCAS Y. S.; BORBA, EDUARDO F.; MACIEL, GUSTAVO A. R.; SOARES-JUNIOR, JOSE M.; BARACAT, EDMUND C.; PEREIRA, ROSA M. R.; BONFA, ELOISA; et al. Adrenal steroidogenesis and ovarian reserve in adult childhood-onset systemic lupus erytematosus patients. CLINICAL RHEUMATOLOGY, v. 40, n. 9, p. 3651-3658, SEP 2021. (15/03756-4)

MEDEIROS-RIBEIRO, ANA C.; AIKAWA, NADIA E.; SAAD, CARLA G. S.; YUKI, EMILY F. N.; PEDROSA, TATIANA; FUSCO, SOLANGE R. G.; ROJO, PRISCILA T.; PEREIRA, ROSA M. R.; SHINJO, SAMUEL K.; ANDRADE, DANIELI C. O.; et al. Immunogenicity and safety of the CoronaVac inactivated vaccine in patients with autoimmune rheumatic diseases: a phase 4 trial. Nature Medicine, v. 27, n. 10, JUL 2021. (18/09937-9, 17/14352-7, 19/21173-7, 15/03756-4, 20/11677-5)

DUARTE, NILO J. C.; KUPA, LEONARD V. K.; FERREIRA-FILHO, JULIO C. R.; FONTOURA, NICOLE; CHALOM, MARC Y.; ROMANO, PASCHOALINA; EBNER, PERSIO A. R.; SILVA, CLOVIS A. A.; CARVALHO, VALDEMIR M.; BONFA, ELOISA. UHPLC-MS/MS Method for Determination of Hydroxychloroquine and Its Main Metabolites in Oral Fluid and Whole Blood for Therapeutic Drug Monitoring. JOURNAL OF APPLIED LABORATORY MEDICINE, v. 6, n. 4, p. 868-880, JUL 2021. (15/03756-4, 17/11644-7, 17/11516-9, 19/17272-0, 17/03983-6)

LIMA FARHAT, SYLVIA COSTA; EJNISMAN, CAROLINA; FERREIRA ALVES, ANDRESSA GUARIENTO; GIACOMIN GOULART, MARIA FERNANDA; DE FARIA COIMBRA LICHTENFELS, ANA JULIA; FERREIRA BRAGA, ALFESIO LUIS; AMADOR PEREIRA, LUIZ ALBERTO; ELIAS, ADRIANA MALUF; SILVA, CLOVIS A.. Air pollution influence on serum inflammatory interleukins: A prospective study in childhood-onset systemic lupus erythematous patients. Lupus, v. 30, n. 14, DEC 2021. (13/21508-2, 15/03756-4)

MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; ASTLEY, CAMILLA; IRAHA, AMANDA YURI; PINTO, ANA JESSICA; MARQUES, ISABELA GOUVEIA; CORDEIRO AMARANTE, MILLA; REZENDE, NATHALIA SAFFIOTI; SIECZKOWSKA, SOFIA MENDES; FRANCO, TATHIANE CHRISTINE; et al. Changes in Eating Habits and Sedentary Behavior During the COVID-19 Pandemic in Adolescents With Chronic Conditions. FRONTIERS IN PEDIATRICS, v. 9, DEC 13 2021. (19/20814-9, 19/14819-8, 19/14820-6, 16/00006-7, 17/13552-2, 19/15231-4, 15/03756-4, 15/26937-4)

ETRUSCO ZARONI SANTOS, ANA CAROLINA; LUGLIO, MICHELE; DELGADO, ARTUR FIGUEIREDO; SANTO VIEIRA SCHUWARTZ, CONSTANCE DELL; SOUSA MARQUES, HELOISA HELENA; DE MIRANDA VALOES, CLARISSA CARVALHO; CABRERA DOMINGUEZ, MARIA ANDREINA; DE CARVALHO, WERTHER BRUNOW; SILVA, CLOVIS ARTUR; DUARTE-NETO, AMARO NUNES. Acute petrified myocardium associated with meningococcal sepsis in childhood-onset systemic lupus erythematous: a fatal case. Revista do Instituto de Medicina Tropical de São Paulo, v. 61, 2019. (15/03756-4)

AIKAWA, NADIA E.; KUPA, LEONARD V. K.; PASOTO, SANDRA G.; MEDEIROS-RIBEIRO, ANA C.; YUKI, EMILY F. N.; SAAD, CARLA G. S.; PEDROSA, TATIANA; FULLER, RICARDO; SHINJO, SAMUEL K.; SAMPAIO-BARROS, PERCIVAL D.; et al. mmunogenicity and safety of two doses of the CoronaVac SARS-CoV-2 vaccine in SARS-CoV-2 seropositive and seronegative patients with autoimmune rheumatic diseases in Brazil: a subgroup analysis of a phase 4 prospective stud. LANCET RHEUMATOLOGY, v. 4, n. 2, p. E113-E124, FEB 2022. (17/14352-7, 19/17272-0, 15/03756-4)

PASOTO, SANDRA GOFINET; DE OLIVEIRA MARTINS, VICTOR ADRIANO; BONFA, ELOISA. Sjogren's syndrome and systemic lupus erythematosus: links and risks. OPEN ACCESS RHEUMATOLOGY-RESEARCH AND REVIEWS, v. 11, p. 33-45, 2019. (18/09937-9, 15/03756-4)

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SILVA, CLOVIS A.; TERRERI, MARIA T.; BONFA, ELOISA; SAAD-MAGALHAES, CLAUDIA. Pediatric rheumatic disease patients: time to extend the age limit of adolescence?. ADVANCES IN RHEUMATOLOGY, v. 58, SEP 18 2018. (15/03756-4)

DINIS, VALQUIRIA G.; VIANA, VILMA T.; LEON, ELAINE P.; SILVA, CLOVIS A.; SAAD, CARLA G.; MORAES, JULIO C.; BONFA, ELOISA S.; MEDEIROS-RIBEIRO, ANA C.. Abatacept induced long-term non-progressive reduction in gamma-globulins and autoantibodies: dissociation from disease activity control. CLINICAL RHEUMATOLOGY, v. 39, n. 6, p. 1747-1755, JUN 2020. (15/03756-4)

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NEVES YUKI, EMILY FIGUEIREDO; SILVA, CLOVIS A.; AIKAWA, NADIA E.; ROMITI, RICARDO; HEISE, CARLOS OTTO; BONFA, ELOISA; PASOTO, SANDRA GOFINET. Thalidomide and Lenalidomide for Refractory Systemic/Cutaneous Lupus Erythematosus Treatment A Narrative Review of Literature for Clinical Practice. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, v. 27, n. 6, p. 248-259, SEP 2021. (15/03756-4)

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ISLABAO, ALINE GARCIA; TRINDADE, VITOR CAVALCANTI; DA MOTA, LICIA MARIA HENRIQUE; ANDRADE, DANIELI CASTRO OLIVEIRA; SILVA, CLOVIS ARTUR. Managing Antiphospholipid Syndrome in Children and Adolescents: Current and Future Prospects. PEDIATRIC DRUGS, v. 24, n. 1, DEC 2021. (15/03756-4)

GUALANO, BRUNO; SIECZKOWSKA, SOFIA M.; LEMES, ITALO RIBEIRO; DA SILVA, RAFAEL PIRES; PINTO, ANA J.; MAZZOLANI, BRUNA C.; SMAIRA, FABIANA I.; AIKAWA, NADIA E.; KUPA, LEONARD V. K.; PASOTO, SANDRA G.; et al. Physical Activity: A Strategy to Improve Antibody Response to a SARS-CoV-2 Vaccine Booster Dose in Patients With Autoimmune Rheumatic Diseases. JOURNAL OF PHYSICAL ACTIVITY & HEALTH, v. 20, n. 4, p. 6-pg., 2023-03-03. (17/23688-9, 19/14820-6, 17/13552-2, 15/26937-4, 15/03756-4, 20/04877-8, 19/14819-8, 19/15231-4)

MUNHOZ, GABRIELA A.; AIKAWA, NADIA E.; SILVA, CLOVIS A.; PASOTO, SANDRA G.; PEDROSA, TATIANA N.; SEGURO, LUCIANA P. C.; BONFA, ELOISA; BORBA, EDUARDO F.. Short-term Accrual 2019 European League Against Rheumatism/American College of Rheumatology Domains and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage in Lupus Patients With and Without Nephritis at Disease Onset. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, v. 29, n. 4, p. 6-pg., 2023-06-01. (17/14352-7, 18/16162-3, 15/03756-4)

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SMAIRA, FABIANA INFANTE; MAZZOLANI, BRUNA CARUSO; LEMES, ITALO RIBEIRO; DA SILVA, RAFAEL PIRES; PINTO, ANA J.; SIECZKOWSKA, SOFIA M.; AIKAWA, NADIA E.; PASOTO, SANDRA G.; MEDEIROS-RIBEIRO, ANA C.; SAAD, CARLA G. S.; et al. No Associations Between Physical Activity and Immunogenicity in SARS-CoV-2 Seropositive Patients With Autoimmune Rheumatic Diseases Prior to and After Vaccination. JOURNAL OF PHYSICAL ACTIVITY & HEALTH, v. N/A, p. 4-pg., 2023-06-08. (17/23688-9, 19/14820-6, 17/13552-2, 15/26937-4, 15/03756-4, 20/04877-8, 19/14819-8, 19/15231-4)

BALMANT, BIANCA D.; TORRINHAS, RAQUEL S.; ROCHA, ILANNA M.; FONSECA, DANIELLE C.; FORMIGA, FRANCISCO F. C.; BONFA, ELOISA S. D. O.; BORBA, EDUARDO F.; WAITZBERG, DAN L.. SARS-CoV-2 infection, gut dysbiosis, and heterogeneous clinical results of hydroxychloroquine on COVID-19 therapy-Is there a link?. NUTRITION, v. 85, p. 3-pg., 2021-02-02. (18/16162-3, 15/03756-4)

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