Home-Based Exercise Training in Childhood-Onset Takayasu Arteritis: A Multicenter, Randomized, Controlled Trial

Author(s):Show less -

Astley, Camilla ^[1] ; Clemente, Gleice ^[2] ; Terreri, Maria Teresa ^[2] ; Carneiro, Camila G. ^[3] ; Lima, Marcos S. ^[3] ; Buchpiguel, Carlos Alberto ^[3] ; Leao Filho, Hilton ^[4] ; Pinto, Ana Lucia de Sa ^{[1, 5]} ; Silva, Clovis Artur ^[6] ; Arruda Campos, Lucia Maria ^[6] ; Aikawa, Nadia Emi ^{[5, 6]} ; Gil, Saulo ^[1] ; Rodrigues Pereira, Rosa Maria ^[5] ; Roschel, Hamilton ^[1] ; Gualano, Bruno ^[1]

Affiliation

^[1] Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Lab Assessment & Conditioning Rheumatol, Fac Med Univ Sao Paulo FMUSP, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Pediat, Div Pediat Rheumatol, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Hosp Clin Fac Med Univ Sao Paulo HCFMUSP, Fac Med, Dept Radiol & Oncol, Lab Nucl Med 43, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Hosp Clin Fac Med Univ Sao Paulo HCFMUSP, Fac Med, Radiol Inst, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Hosp Clin Fac Med Univ Sao Paulo HCFMUSP, Rheumatol Div, Fac Med, Sao Paulo - Brazil

^[6] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Childrens Inst, Pediat Rheumatol Unit, Sao Paulo - Brazil

• Document type: Journal article
• Source: FRONTIERS IN IMMUNOLOGY; v. 12, JUL 28 2021.
• Web of Science Citations: 0

Abstract

Introduction: Childhood-onset Takayasu Arteritis (c-TA) is a rare, large-vessel vasculitis seen in children that could predisposing patients to a high risk of mortality. Exercise has the potential to improve overall health in several diseases, but evidence remains scant in c-TA. The main objective of this study was to investigate the safety and potential therapeutic effects of exercise in c-TA. Methods: This was a 12-week, multicenter, randomized, controlled trial, to test the effects of a home-based, exercise intervention vs. standard of care in c-TA patients in remission. The primary outcomes were arterial inflammation, assessed by {[}F-18] FDG-PET/MRI and systemic inflammatory markers. Secondary outcomes included, physical activity levels, functionality, body composition, disease-related parameters, and quality of life. Results: Thirty-seven patients were assessed for eligibility, which represents the total number of c-TA patients being followed by the three specialized medical ambulatory services in Sao Paulo. After exclusions, fourteen c-TA patients (71.4% females) aged 12-25 years were randomly allocated into exercised (n=5) and non-exercised groups (n=9). Exercise did not exacerbate arterial inflammation. In fact, exercised patients had a reduction in the frequency of vessel segments with severe inflammation, whereas the non-exercised patients had an opposite response (P=0.007). Greater improvements in visceral fat, steps per day, functionality and physical component SF-36 were observed in the exercised patients (P <= 0.05). Conclusions: Exercise is safe and may improve visceral fat, physical activity levels, functionality, and physical component SF-36 in c-TA patients. Thus, exercise arises as a novel, evidence-based intervention to improve general health in c-TA. (AU)

• FAPESP's process: 15/03756-4 - Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy
• Grantee: Eloisa Silva Dutra de Oliveira Bonfá
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 17/07358-9 - Physical activity in patients with Juvenile Takayasu Arteritis: Clinical effects and mechanisms of action.
• Grantee: Camilla Astley Amaral Pedroso
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 17/13552-2 - Reducing sedentary time in clinical populations: the take a stand for health study
• Grantee: Bruno Gualano
• Support Opportunities: Research Projects - Thematic Grants