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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Home-Based Exercise Training in Childhood-Onset Takayasu Arteritis: A Multicenter, Randomized, Controlled Trial

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Astley, Camilla [1] ; Clemente, Gleice [2] ; Terreri, Maria Teresa [2] ; Carneiro, Camila G. [3] ; Lima, Marcos S. [3] ; Buchpiguel, Carlos Alberto [3] ; Leao Filho, Hilton [4] ; Pinto, Ana Lucia de Sa [1, 5] ; Silva, Clovis Artur [6] ; Arruda Campos, Lucia Maria [6] ; Aikawa, Nadia Emi [5, 6] ; Gil, Saulo [1] ; Rodrigues Pereira, Rosa Maria [5] ; Roschel, Hamilton [1] ; Gualano, Bruno [1]
Total Authors: 15
[1] Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Lab Assessment & Conditioning Rheumatol, Fac Med Univ Sao Paulo FMUSP, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Pediat, Div Pediat Rheumatol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Hosp Clin Fac Med Univ Sao Paulo HCFMUSP, Fac Med, Dept Radiol & Oncol, Lab Nucl Med 43, Sao Paulo - Brazil
[4] Univ Sao Paulo, Hosp Clin Fac Med Univ Sao Paulo HCFMUSP, Fac Med, Radiol Inst, Sao Paulo - Brazil
[5] Univ Sao Paulo, Hosp Clin Fac Med Univ Sao Paulo HCFMUSP, Rheumatol Div, Fac Med, Sao Paulo - Brazil
[6] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Childrens Inst, Pediat Rheumatol Unit, Sao Paulo - Brazil
Total Affiliations: 6
Document type: Journal article
Source: FRONTIERS IN IMMUNOLOGY; v. 12, JUL 28 2021.
Web of Science Citations: 0

Introduction: Childhood-onset Takayasu Arteritis (c-TA) is a rare, large-vessel vasculitis seen in children that could predisposing patients to a high risk of mortality. Exercise has the potential to improve overall health in several diseases, but evidence remains scant in c-TA. The main objective of this study was to investigate the safety and potential therapeutic effects of exercise in c-TA. Methods: This was a 12-week, multicenter, randomized, controlled trial, to test the effects of a home-based, exercise intervention vs. standard of care in c-TA patients in remission. The primary outcomes were arterial inflammation, assessed by {[}F-18] FDG-PET/MRI and systemic inflammatory markers. Secondary outcomes included, physical activity levels, functionality, body composition, disease-related parameters, and quality of life. Results: Thirty-seven patients were assessed for eligibility, which represents the total number of c-TA patients being followed by the three specialized medical ambulatory services in Sao Paulo. After exclusions, fourteen c-TA patients (71.4% females) aged 12-25 years were randomly allocated into exercised (n=5) and non-exercised groups (n=9). Exercise did not exacerbate arterial inflammation. In fact, exercised patients had a reduction in the frequency of vessel segments with severe inflammation, whereas the non-exercised patients had an opposite response (P=0.007). Greater improvements in visceral fat, steps per day, functionality and physical component SF-36 were observed in the exercised patients (P <= 0.05). Conclusions: Exercise is safe and may improve visceral fat, physical activity levels, functionality, and physical component SF-36 in c-TA patients. Thus, exercise arises as a novel, evidence-based intervention to improve general health in c-TA. (AU)

FAPESP's process: 15/03756-4 - Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy
Grantee:Eloisa Silva Dutra de Oliveira Bonfá
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 17/07358-9 - Physical activity in patients with Juvenile Takayasu Arteritis: Clinical effects and mechanisms of action.
Grantee:Camilla Astley Amaral Pedroso
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 17/13552-2 - Reducing sedentary time in clinical populations: the take a stand for health study
Grantee:Bruno Gualano
Support Opportunities: Research Projects - Thematic Grants