| Full text | |
| Author(s): Show less - |
Astley, Camilla
[1]
;
Clemente, Gleice
[2]
;
Terreri, Maria Teresa
[2]
;
Carneiro, Camila G.
[3]
;
Lima, Marcos S.
[3]
;
Buchpiguel, Carlos Alberto
[3]
;
Leao Filho, Hilton
[4]
;
Pinto, Ana Lucia de Sa
[1, 5]
;
Silva, Clovis Artur
[6]
;
Arruda Campos, Lucia Maria
[6]
;
Aikawa, Nadia Emi
[5, 6]
;
Gil, Saulo
[1]
;
Rodrigues Pereira, Rosa Maria
[5]
;
Roschel, Hamilton
[1]
;
Gualano, Bruno
[1]
Total Authors: 15
|
| Affiliation: | [1] Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Lab Assessment & Conditioning Rheumatol, Fac Med Univ Sao Paulo FMUSP, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Pediat, Div Pediat Rheumatol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Hosp Clin Fac Med Univ Sao Paulo HCFMUSP, Fac Med, Dept Radiol & Oncol, Lab Nucl Med 43, Sao Paulo - Brazil
[4] Univ Sao Paulo, Hosp Clin Fac Med Univ Sao Paulo HCFMUSP, Fac Med, Radiol Inst, Sao Paulo - Brazil
[5] Univ Sao Paulo, Hosp Clin Fac Med Univ Sao Paulo HCFMUSP, Rheumatol Div, Fac Med, Sao Paulo - Brazil
[6] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Childrens Inst, Pediat Rheumatol Unit, Sao Paulo - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | FRONTIERS IN IMMUNOLOGY; v. 12, JUL 28 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Introduction: Childhood-onset Takayasu Arteritis (c-TA) is a rare, large-vessel vasculitis seen in children that could predisposing patients to a high risk of mortality. Exercise has the potential to improve overall health in several diseases, but evidence remains scant in c-TA. The main objective of this study was to investigate the safety and potential therapeutic effects of exercise in c-TA. Methods: This was a 12-week, multicenter, randomized, controlled trial, to test the effects of a home-based, exercise intervention vs. standard of care in c-TA patients in remission. The primary outcomes were arterial inflammation, assessed by {[}F-18] FDG-PET/MRI and systemic inflammatory markers. Secondary outcomes included, physical activity levels, functionality, body composition, disease-related parameters, and quality of life. Results: Thirty-seven patients were assessed for eligibility, which represents the total number of c-TA patients being followed by the three specialized medical ambulatory services in Sao Paulo. After exclusions, fourteen c-TA patients (71.4% females) aged 12-25 years were randomly allocated into exercised (n=5) and non-exercised groups (n=9). Exercise did not exacerbate arterial inflammation. In fact, exercised patients had a reduction in the frequency of vessel segments with severe inflammation, whereas the non-exercised patients had an opposite response (P=0.007). Greater improvements in visceral fat, steps per day, functionality and physical component SF-36 were observed in the exercised patients (P <= 0.05). Conclusions: Exercise is safe and may improve visceral fat, physical activity levels, functionality, and physical component SF-36 in c-TA patients. Thus, exercise arises as a novel, evidence-based intervention to improve general health in c-TA. (AU) | |
| FAPESP's process: | 15/03756-4 - Assessment of relevance of blood levels of drugs in the monitoring rheumatic autoimmune diseases: safety, effectiveness and adherence to therapy |
| Grantee: | Eloisa Silva Dutra de Oliveira Bonfá |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 17/07358-9 - Physical activity in patients with Juvenile Takayasu Arteritis: Clinical effects and mechanisms of action. |
| Grantee: | Camilla Astley Amaral Pedroso |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 17/13552-2 - Reducing sedentary time in clinical populations: the take a stand for health study |
| Grantee: | Bruno Gualano |
| Support Opportunities: | Research Projects - Thematic Grants |