Home-Based Exercise Training in Childhood-Onset Takayasu Arteritis: A Multicenter, Randomized, Controlled Trial

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Astley, Camilla ^[1] ; Clemente, Gleice ^[2] ; Terreri, Maria Teresa ^[2] ; Carneiro, Camila G. ^[3] ; Lima, Marcos S. ^[3] ; Buchpiguel, Carlos Alberto ^[3] ; Leao Filho, Hilton ^[4] ; Pinto, Ana Lucia de Sa ^{[1, 5]} ; Silva, Clovis Artur ^[6] ; Arruda Campos, Lucia Maria ^[6] ; Aikawa, Nadia Emi ^{[5, 6]} ; Gil, Saulo ^[1] ; Rodrigues Pereira, Rosa Maria ^[5] ; Roschel, Hamilton ^[1] ; Gualano, Bruno ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Lab Assessment & Conditioning Rheumatol, Fac Med Univ Sao Paulo FMUSP, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Pediat, Div Pediat Rheumatol, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Hosp Clin Fac Med Univ Sao Paulo HCFMUSP, Fac Med, Dept Radiol & Oncol, Lab Nucl Med 43, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Hosp Clin Fac Med Univ Sao Paulo HCFMUSP, Fac Med, Radiol Inst, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Hosp Clin Fac Med Univ Sao Paulo HCFMUSP, Rheumatol Div, Fac Med, Sao Paulo - Brazil

^[6] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Childrens Inst, Pediat Rheumatol Unit, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN IMMUNOLOGY; v. 12, JUL 28 2021.
• Citações Web of Science: 0

Resumo

Introduction: Childhood-onset Takayasu Arteritis (c-TA) is a rare, large-vessel vasculitis seen in children that could predisposing patients to a high risk of mortality. Exercise has the potential to improve overall health in several diseases, but evidence remains scant in c-TA. The main objective of this study was to investigate the safety and potential therapeutic effects of exercise in c-TA. Methods: This was a 12-week, multicenter, randomized, controlled trial, to test the effects of a home-based, exercise intervention vs. standard of care in c-TA patients in remission. The primary outcomes were arterial inflammation, assessed by {[}F-18] FDG-PET/MRI and systemic inflammatory markers. Secondary outcomes included, physical activity levels, functionality, body composition, disease-related parameters, and quality of life. Results: Thirty-seven patients were assessed for eligibility, which represents the total number of c-TA patients being followed by the three specialized medical ambulatory services in Sao Paulo. After exclusions, fourteen c-TA patients (71.4% females) aged 12-25 years were randomly allocated into exercised (n=5) and non-exercised groups (n=9). Exercise did not exacerbate arterial inflammation. In fact, exercised patients had a reduction in the frequency of vessel segments with severe inflammation, whereas the non-exercised patients had an opposite response (P=0.007). Greater improvements in visceral fat, steps per day, functionality and physical component SF-36 were observed in the exercised patients (P <= 0.05). Conclusions: Exercise is safe and may improve visceral fat, physical activity levels, functionality, and physical component SF-36 in c-TA patients. Thus, exercise arises as a novel, evidence-based intervention to improve general health in c-TA. (AU)

• Processo FAPESP: 15/03756-4 - Avaliação da relevância dos níveis sanguíneos de drogas utilizadas em doenças autoimunes reumatológicas no acompanhamento da segurança, eficácia e aderência à terapêutica
• Beneficiário: Eloisa Silva Dutra de Oliveira Bonfá
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/07358-9 - Atividade física em pacientes com Arterite de Takayasu Juvenil: Efeitos clínicos e mecanismos de ação.
• Beneficiário: Camilla Astley Amaral Pedroso
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 17/13552-2 - Reduzindo tempo sedentário em populações clínicas: o estudo take a stand for health
• Beneficiário: Bruno Gualano
• Modalidade de apoio: Auxílio à Pesquisa - Temático