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Short and long-term effects of a home-based pulmonary rehabilitation on functional capacity, peripheral muscle strength and quality of life: a randomized controlled trial.

Grant number: 16/13756-4
Support Opportunities:Regular Research Grants
Duration: February 01, 2017 - July 31, 2019
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Simone Dal Corso
Grantee:Simone Dal Corso
Host Institution: Universidade Nove de Julho (UNINOVE). Campus Vergueiro. São Paulo , SP, Brazil
Associated researchers: Anne Elizabeth Holland ; Rafael Stelmach


Introduction: Home-based pulmonary rehabilitation (HBPR) has been used in patients with chronic obstructive pulmonary disease, asthma and pulmonary fibrosis. Results from HBPR have been similar to those observe in the outpatient pulmonary rehabilitation such improvement in exercise capacity, symptoms and quality of life. However, HBPR has not yet been investigated in patients with bronchiectasis, a progressive and debilitating disease with a high socioeconomic impact. Objective: To investigate the short-and long-term effects of the RPD in peripheral muscle strength, functional capacity and quality of life in patients with bronchiectasis. Methods: A randomized-controlled trial with 66 patients (according to sample size calculation) diagnosed with bronchiectasis will be recruited from the Obstructive Diseases Outpatient Clinic of the Hospital das Clínicas - Medicine School, University of São Paulo. Participants will be randomized into two groups: control group (usual care and recommendations for performing exercises and respiratory physiotherapy, n =33) and training group (n = 33), that will perform aerobic (stepping training) and resistance training (lower and upper limbs) for eight weeks, three times a week. All patients will receive a phone call once a week and patients allocated in the training group, additionally, will receive a home visit every 15 days. At baseline, immediately after finishing and after six months of the HBPR patients will undergo to assessment of the exercise tolerance and functional capacity through the incremental shuttle walk test, endurance shuttle walk test and incremental step test; the quality of life will be evaluated through Quality of Life Questionnaire-Bronchiectasis (QOL-B), dyspnea by the Medical Research Council scale, physical activity in daily life through a pedometer and peripheral muscle strength by the one-repetition maximum. Expected results: HBPR will have positive effects on exercise tolerance and quality of life. In addition, this study will contribute to future guidelines on the recommendation of HBPR for patients with bronchiectasis. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
JOSE, ANDERSON; HOLLAND, ANNE E.; SELMAN, JESSYCA P. R.; DE CAMARGO, CRISTIANE OLIVEIRA; FONSECA, DIOGO SIMOES; ATHANAZIO, RODRIGO A.; RACHED, SAMIA Z.; CUKIER, ALBERTO; STELMACH, RAFAEL; DAL CORSO, SIMONE. Home-based pulmonary rehabilitation in people with bronchiectasis: a randomised controlled trial. ERJ OPEN RESEARCH, v. 7, n. 2, . (16/13756-4)
JOSE, ANDERSON; HOLLAND, ANNE E.; DE OLIVEIRA, CRISTIANE S.; SELMAN, JESSYCA P. R.; DE CASTRO, REJANE A. S.; ATHANAZIO, RODRIGO A.; RACHED, SAMIA Z.; CUKIER, ALBERTO; STELMACH, RAFAEL; DAL CORSO, SIMONE. Does home-based pulmonary rehabilitation improve functional capacity, peripheral muscle strength and quality of life in patients with bronchiectasis compared to standard care?. BRAZILIAN JOURNAL OF PHYSICAL THERAPY, v. 21, n. 6, p. 473-480, . (16/13756-4)

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