Reducing sedentary time in clinical populations: the take a stand for health study

• Grant number: 17/13552-2
• Support Opportunities: Research Projects - Thematic Grants
• Start date: April 01, 2019
• End date: August 31, 2024
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Bruno Gualano
• Grantee: Bruno Gualano
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Pesquisadores principais: Hamilton Augusto Roschel da Silva
• Associated researchers: Ana Jéssica Pinto ; Ana Lúcia de Sá Pinto ; David Dunstan ; Eloisa Silva Dutra de Oliveira Bonfá ; Ernani Pinto Junior ; Fabiana Braga Benatti ; Fábio Henrique de Gobbi Porto ; Fernanda Rodrigues Lima ; James Turner ; John Patrick Kirwan ; Marco Aurélio Santo ; Maria Claudia Costa Irigoyen ; Miriam Sanz Roldán ; Neville Owen ; Roberto de Cleva ; Rosa Maria Rodrigues Pereira ; Sonia Maria Dozzi Brucki
• Associated scholarship(s): 21/13580-1 - Effects of home-based exercise training on quality of life and general health of severe COVID-19 survivors, BP.DD; 22/12890-0 - Reducing sedentary time in clinical populations: The Take a STAND for health study, BP.PD; 22/12770-4 - Reducing sedentary time in clinical populations: The Take a STAND for health study, BP.PD; + associated scholarships 22/08306-0 - Reducing sedentary time in clinical populations: the Take a STAND for health study, BP.IC; 22/08862-0 - Reducing sedentary time in clinical populations: The Take a STAND for health study, BP.TT; 21/10385-3 - Reducing sedentary time in clinical populations: the take a stand for health study, BP.TT; 21/04616-2 - Reducing sedentary time in clinical populations: the take a stand for health study, BP.IC; 19/22160-6 - Reducing sedentary time in bariatric patients: a proof-of-concept, laboratorial study, BP.PD; 19/20814-9 - Reducing sedentary time in mild cognitive impairment patients: a randomized controlled trial, BP.PD; 19/18039-7 - Reducing sedentary time in bariatric patients: a randomized controlled trial, BP.PD - associated scholarships

Abstract

Cumulative evidence has shown that sedentary behavior (i.e., excessive time spent while in a sitting or reclining posture) is a strong and independent factor predisposing to poor health-related outcomes and all-cause mortality in several populations. In this context, new interventions focused on reducing sedentary time could be of great therapeutic relevance. To date, however, studies assessing this topic remain scarce. This research program aims to comprehensively investigate the clinical, physiological, metabolic, and molecular effects of reducing sedentary behavior in specific clinical populations. To that end, we will perform three distinct randomized controlled trials and three acute laboratorial studies involving rheumatoid arthritis, bariatric and mild cognitive impairment patients. All of these studies are under the umbrella title Take a stand for health. The 4-month parallel-group randomized controlled trials aim to investigate the feasibility and efficacy of a newly developed personalized intervention focused on replacing sedentary time with light-(or very light-) intensity physical activity in these populations. A multitude of gold-standard techniques will be applied to evaluate the effects of the intervention on several outcomes, including sedentary time (primary outcome), physical activity levels, clinical parameters specific to each condition, cardiometabolic risk factors, immune function, and health-related quality of life. In addition, skeletal muscle and blood samples will be collected and a variety of molecular analyses will be performed to gather knowledge on the potential mechanisms which underpin the response to this intervention. The cross-over acute studies mainly aim to unravel potential mechanisms underlying the effects of successive breaks in prolonged sitting (i.e., 3-minute bouts of light-intensity walking every 30 minutes for 8 hours) versus 30-minutes of exercise followed by prolonged sitting or prolonged sitting only (control condition), in a well-controlled laboratorial condition. We will assess physiological and metabolic parameters (i.e., arterial blood pressure, heart rate, insulin sensitivity surrogates, lipid profile, and inflammatory markers) throughout the experimental sessions. In addition, we will explore the molecular responses in skeletal muscle and in blood, elicited by the interventions, through targeted analyses of candidate genes and proteins potentially modulated by physical (in)activity as well as untargeted analyses, by means of proteomic and metabolomic approaches. Our research team involves several national and international leading experts who act from clinical to translational sciences; and our research facilities are perfectly suited to conducting the planned studies. Findings emerging from this research program will be of paramount clinical relevance since they could provide the foundation for new prescriptions focused on reducing sedentary behavior, which is an important, modifiable and so far, overlooked risk factor in clinical populations. From a scientific standpoint, this project will originate a body of cutting-edge data, which could be highly influential in broad scientific fields, including Medical Sciences, Exercise Science, Public Health, and Basic Sciences. (AU)

Scientific publications

(56)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MURAI, IGOR H.; FERNANDES, ALAN L.; SALES, LUCAS P.; PINTO, ANA J.; GOESSLER, KARLA F.; DURAN, CAMILA S. C.; SILVA, CARLA B. R.; FRANCO, ANDRE S.; MACEDO, MARINA B.; DALMOLIN, HENRIQUE H. H.; et al. Effect of a Single High Dose of Vitamin D-3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19 A Randomized Clinical Trial. JAMA, v. 325, n. 11, FEB 2021. (20/11102-2, 15/26937-4, 17/13552-2, 19/24782-4, 19/18039-7, 20/05752-4, 16/00006-7)

SIECZKOWSKA, MENDES; SMAIRA, FABIANA INFANTE; MAZZOLANI, BRUNA CARUSO; GUALANO, BRUNO; ROSCHEL, HAMILTON; PECANHA, TIAGO. Efficacy of home-based physical activity interventions in patients with autoimmune rheumatic diseases: A systematic review and meta-analysis. SEMINARS IN ARTHRITIS AND RHEUMATISM, v. 51, n. 3, p. 576-587, JUN 2021. (19/07150-4, 19/14820-6, 17/13552-2, 16/23319-0, 19/14819-8, 19/15231-4)

GONCALVES, LIVIA DE SOUZA; SALES, LUCAS PEIXOTO; SAITO, TIEMI RAQUEL; CAMPOS, JULIANE CRUZ; FERNANDES, ALAN LINS; NATALI, JOSE; JENSEN, LEONARDO; ARNOLD, ALEXANDRE; RAMALHO, LISLEY; BECHARA, LUIZ ROBERTO GRASSMANN; et al. Histidine dipeptides are key regulators of excitation-contraction coupling in cardiac muscle: Evidence from a novel CARNS1 knockout rat model. REDOX BIOLOGY, v. 44, AUG 2021. (17/16540-5, 13/14746-4, 17/11142-1, 13/07937-8, 17/13552-2, 19/24899-9, 18/14544-6, 19/25032-9, 14/11948-8, 20/04006-7)

NICOLETTI, CAROLINA FERREIRA; ESTEVES, GABRIEL PERRI; GENARIO, RAFAEL; SANTO, MARCO AURELIO; DE CLEVA, ROBERTO; GUALANO, BRUNO; ROSCHEL, HAMILTON. Nutritional Inadequacies Among Post-bariatric Patients During COVID-19 Quarantine in Sao Paulo, Brazil. OBESITY SURGERY, v. 31, n. 5, NOV 2020. (20/07860-9, 19/18039-7, 15/26937-4, 17/13552-2)

DOLAN, EIMEAR; ARTIOLI, GUILHERME G.; PEREIRA, ROSA MARIA R.; GUALANO, BRUNO. Muscular Atrophy and Sarcopenia in the Elderly: Is There a Role for Creatine Supplementation?. BIOMOLECULES, v. 9, n. 11, NOV 2019. (19/05616-6, 17/13552-2)

BARRETO, GABRIEL; GRECCO, BEATRIZ; MEROLA, PIETRO; GONCALVES REIS, CAIO EDUARDO; GUALANO, BRUNO; SAUNDERS, BRYAN. Novel insights on caffeine supplementation, CYP1A2 genotype, physiological responses and exercise performance. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 121, n. 3, JAN 2021. (17/15314-1, 17/13552-2, 20/02391-0, 16/50438-0)

ASTLEY, CAMILLA; PINTO, ANA JESSICA; BONFA, ELOISA; DA SILVA, CLOVIS ARTUR ALMEIDA; GUALANO, BRUNO. Gaps on rheumatologists' knowledge of physical activity. CLINICAL RHEUMATOLOGY, v. 40, n. 7, JAN 2021. (15/26937-4, 17/13552-2, 15/03756-4)

ASTLEY, CAMILLA; CLEMENTE, GLEICE; TERRERI, MARIA TERESA; CARNEIRO, CAMILA G.; LIMA, MARCOS S.; BUCHPIGUEL, CARLOS ALBERTO; LEAO FILHO, HILTON; PINTO, ANA LUCIA DE SA; SILVA, CLOVIS ARTUR; ARRUDA CAMPOS, LUCIA MARIA; et al. Home-Based Exercise Training in Childhood-Onset Takayasu Arteritis: A Multicenter, Randomized, Controlled Trial. FRONTIERS IN IMMUNOLOGY, v. 12, JUL 28 2021. (15/03756-4, 17/07358-9, 17/13552-2)

GUALANO, BRUNO; LEMES, ITALO R.; SILVA, RAFAEL P.; PINTO, ANA J.; MAZZOLANI, BRUNA C.; SMAIRA, FABIANA, I; SIECZKOWSKA, SOFIA M.; AIKAWA, NADIA E.; PASOTO, SANDRA G.; MEDEIROS-RIBEIRO, ANA C.; et al. Association between physical activity and immunogenicity of an inactivated virus vaccine against SARS-CoV-2 in patients with autoimmune rheumatic diseases. BRAIN BEHAVIOR AND IMMUNITY, v. 101, p. 8-pg., 2022-03-01. (19/14819-8, 15/03756-4, 15/26937-4, 19/15231-4, 17/23688-9, 17/13552-2, 19/14820-6)

CRISTINA-OLIVEIRA, MICHELLE; MEIRELES, KAMILA; GIL, SAULO; ASSIS, FABIO CAVALCANTE; GEBER-JUNIOR, JOAO CARLOS; SHINJO, SAMUEL KATSUYUKI; DE SOUZA, HERALDO POSSOLO; CRUZ SANTANA, ALFREDO NICODEMOS; SWINTON, PAUL A.; DRAGER, LUCIANO F.; et al. Carotid intima-media thickness and flow-mediated dilation do not predict acute in-hospital outcomes in patients hospitalized with COVID-19. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 322, n. 6, p. 8-pg., 2022-04-01. (17/13552-2, 16/23319-0)

SMAIRA, FABIANA INFANTE; MAZZOLANI, BRUNA CARUSO; ESTEVES, GABRIEL PERRI; ANDRE, HELOISA C. SANTO; AMARANTE, MILLA CORDEIRO; CASTANHO, DANIELA FERNANDES; CAMPOS, KAREN JENNIFER DE; BENATTI, FABIANA BRAGA; PINTO, ANA JESSICA; ROSCHEL, HAMILTON; et al. Poor Eating Habits and Selected Determinants of Food Choice Were Associated With Ultraprocessed Food Consumption in Brazilian Women During the COVID-19 Pandemic. FRONTIERS IN NUTRITION, v. 8, MAY 13 2021. (19/14819-8, 20/07860-9, 17/13552-2, 15/26937-4, 19/14820-6)

ESTEVES, GABRIEL P.; NOVELLI, FABIULA ISOTON; MELETTI, MATHEUS MOLINA; COSTA, LUIZ AUGUSTO RIANI; DO PRADO, DANILO MARCELO LEITE; MOLLER, GABRIELLA BERWIG; MARTICORENA, FELIPE MIGUEL; FRANCO, RUTH ROCHA; COMINATO, LOUISE; DOS SANTOS, CLAUDIA RENATA PINTO; et al. Cloth masks during exercise are safe and tolerable for children with overweight and obesity. PEDIATRIC PULMONOLOGY, v. 58, n. 7, p. 4-pg., 2023-05-03. (21/05847-8, 19/18039-7, 17/13552-2, 20/07860-9, 20/15678-6)

GIL, SAULO; GUALANO, BRUNO; DE ARAUJO, ADRIANA LADEIRA; DE OLIVEIRA JUNIOR, GERSIEL NASCIMENTO; DAMIANO, RODOLFO FURLAN; PINNA, FABIO; IMAMURA, MARTA; ROCHA, VANDERSON; KALLAS, ESPER; BATISTELLA, LINAMARA RIZZO; et al. Post-acute sequelae of SARS-CoV-2 associates with physical inactivity in a cohort of COVID-19 survivors. SCIENTIFIC REPORTS, v. 13, n. 1, p. 8-pg., 2023-01-05. (17/13552-2, 20/08091-9)

ASTLEY, CAMILLA; LEAL, GABRIELA NUNES; GIL, SAULO; SUGUITA, PRISCILA; FINK, THAIS; BAIN, VERA; PEREIRA, MARIA FERNANDA BADUE; MARQUES, HELOISA HELENA; SIECZKOWSKA, SOFIA; PRADO, DANILO; et al. Home-Based Exercise Training in the Recovery of Multisystem Inflammatory Syndrome in Children: A Case Series Study. CHILDREN-BASEL, v. 10, n. 5, p. 14-pg., 2023-05-16. (17/13552-2, 21/02742-0, 19/15231-4, 15/03756-4)

LONGOBARDI, IGOR; GOESSLER, KARLA; DE OLIVEIRA JR, GERSIEL NASCIMENTO; DO PRADO, DANILO MARCELO LEITE; SANTOS, JHONNATAN VASCONCELOS PEREIRA; MELETTI, MATHEUS MOLINA; DE ANDRADE, DANIELI CASTRO OLIVEIRA; GIL, SAULO; BOZA, JOAO ANTONIO SPOTT DE OLIVEIRA; LIMA, FERNANDA RODRIGUES; et al. Effects of a 16-week home-based exercise training programme on health-related quality of life, functional capacity, and persistent symptoms in survivors of severe/critical COVID-19: a randomised controlled trial. BRITISH JOURNAL OF SPORTS MEDICINE, v. N/A, p. 10-pg., 2023-05-09. (20/08091-9, 19/18039-7, 17/13552-2, 21/13580-1, 20/15678-6, 20/07540-4)

ESTEVES, GABRIEL P.; MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; SANTO ANDRE, HELOISA C.; IRAHA, AMANDA YURI; ASTLEY, CAMILLA; MARQUES, ISABELA GOUVEIA; AMARANTE, MILLA CORDEIRO; REZENDE, NATHALIA SAFFIOTI; SIECZKOWSKA, SOFIA MENDES; et al. Food consumption based on processing level (according to Nova system) during the COVID-19 pandemic among adolescents with immunocompromised conditions: a case-control study. FRONTIERS IN NUTRITION, v. 10, p. 9-pg., 2023-05-16. (21/02742-0, 19/14820-6, 17/13552-2, 15/26937-4, 20/07860-9, 15/03756-4, 20/02741-1, 19/20814-9, 16/00006-7, 19/14819-8, 19/15231-4)

GUARDIEIRO, NATALIA MENDES; BARRETO, GABRIEL; MARTICORENA, FELIPE MIGUEL; OLIVEIRA, TAMIRES NUNES; DE OLIVEIRA, LUANA FARIAS; PINTO, ANA LUCIA DE SA; DO PRADO, DANILO MARCELO LEITE; SAUNDERS, BRYAN; GUALANO, BRUNO. A Cloth Facemask Causes No Major Respiratory or Cardiovascular Perturbations During Moderate to Heavy Exercise. JOURNAL OF PHYSICAL ACTIVITY & HEALTH, v. 20, n. 1, p. 10-pg., 2023-01-01. (21/05847-8, 16/50438-0, 20/12036-3, 17/13552-2, 21/06836-0, 20/04368-6)

SMAIRA, FABIANA INFANTE; MAZZOLANI, BRUNA CARUSO; LEMES, ITALO RIBEIRO; DA SILVA, RAFAEL PIRES; PINTO, ANA J.; SIECZKOWSKA, SOFIA M.; AIKAWA, NADIA E.; PASOTO, SANDRA G.; MEDEIROS-RIBEIRO, ANA C.; SAAD, CARLA G. S.; et al. No Associations Between Physical Activity and Immunogenicity in SARS-CoV-2 Seropositive Patients With Autoimmune Rheumatic Diseases Prior to and After Vaccination. JOURNAL OF PHYSICAL ACTIVITY & HEALTH, v. N/A, p. 4-pg., 2023-06-08. (17/23688-9, 19/14820-6, 17/13552-2, 15/26937-4, 15/03756-4, 20/04877-8, 19/14819-8, 19/15231-4)

PERIM, PEDRO; GOBBI, NATHAN; DUARTE, BRENO; FARIAS DE OLIVEIRA, LUANA; COSTA, LUIZ AUGUSTO RIANI; SALE, CRAIG; GUALANO, BRUNO; DOLAN, EIMEAR; SAUNDERS, BRYAN. Beta-alanine did not improve high-intensity performance throughout simulated road cycling. European Journal of Sport Science, v. 22, n. 8, p. 10-pg., 2021-06-16. (16/50438-0, 19/07497-4, 19/05616-6, 19/06140-5, 18/01594-5, 17/13552-2, 16/17391-0)

ASTLEY, CAMILLA; BADUE PEREIRA, MARIA FERNANDA; LIMA, MARCOS SANTOS; BUCHPIGUEL, CARLOS ALBERTO; CARNEIRO, CAMILA G.; SAPIENZA, MARCELO TATIT; LEAL, GABRIELA NUNES; LEITE DO PRADO, DANILO MARCELO; PECANHA, TIAGO; SIECZKOWSKA, SOFIA MENDES; et al. In-depth cardiovascular and pulmonary assessments in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: A case series study. PHYSIOLOGICAL REPORTS, v. 10, n. 5, p. 9-pg., 2022-03-01. (15/03756-4, 19/15231-4, 17/13552-2)

SIECZKOWSKA, SOFIA MENDES; SMAIRA, FABIANA INFANTE; MAZZOLANI, BRUNA CARUSO; ROMERO, MARINA; PASOTO, SANDRA GOFINET; PINTO, ANA LUCIA DE SA; LIMA, FERNANDA RODRIGUES; DE OLIVEIRA, VICTOR RODRIGUES; UEDA, SERLI; BENATTI, FABIANA BRAGA; et al. A randomized controlled trial of an intervention promoting physical activity and healthy eating recommendations in systemic lupus erythematosus: the protocol study "Living Well with Lupus". RHEUMATOLOGY INTERNATIONAL, v. 43, n. 10, p. 12-pg., 2023-06-24. (17/13552-2, 19/14820-6, 19/15231-4, 19/14819-8)

GUALANO, BRUNO; SIECZKOWSKA, SOFIA M.; LEMES, ITALO RIBEIRO; DA SILVA, RAFAEL PIRES; PINTO, ANA J.; MAZZOLANI, BRUNA C.; SMAIRA, FABIANA I.; AIKAWA, NADIA E.; KUPA, LEONARD V. K.; PASOTO, SANDRA G.; et al. Physical Activity: A Strategy to Improve Antibody Response to a SARS-CoV-2 Vaccine Booster Dose in Patients With Autoimmune Rheumatic Diseases. JOURNAL OF PHYSICAL ACTIVITY & HEALTH, v. 20, n. 4, p. 6-pg., 2023-03-03. (17/23688-9, 19/14820-6, 17/13552-2, 15/26937-4, 15/03756-4, 20/04877-8, 19/14819-8, 19/15231-4)

MARTICORENA, FELIPE MIGUEL; BARRETO, GABRIEL CASTANHO; GUARDIEIRO, NATALIA MENDES; ESTEVES, GABRIEL PERRI; OLIVEIRA, TAMIRES NUNES; DE OLIVEIRA, LUANA FARIAS; PINTO, ANA LUCIA DE SA; RIANI, LUIZ; PRADO, DANILO MENDES; SAUNDERS, BRYAN; et al. Performing moderate to severe activity is safe and tolerable for healthy youth while wearing a cloth facemask. PLoS One, v. 18, n. 3, p. 11-pg., 2023-03-06. (21/05847-8, 16/50438-0, 20/12036-3, 17/13552-2, 20/07860-9, 20/04368-6)

PERIM, PEDRO; GOBBI, NATHAN; DUARTE, BRENO; FARIAS DE OLIVEIRA, LUANA; COSTA, LUIZ AUGUSTO RIANI; SALE, CRAIG; GUALANO, BRUNO; DOLAN, EIMEAR; SAUNDERS, BRYAN. Beta-alanine did not improve high-intensity performance throughout simulated road cycling. European Journal of Sport Science, JUN 2021. (19/07497-4, 17/13552-2, 18/01594-5, 19/06140-5, 16/17391-0, 16/50438-0, 19/05616-6)

PINTO, ANA JESSICA; DUNSTAN, DAVID W.; OWEN, NEVILLE; BONFA, ELOISA; GUALANO, BRUNO. Combating physical inactivity during the COVID-19 pandemic. Nature Reviews Rheumatology, APR 2020. (15/26937-4, 17/13552-2, 18/19418-9, 15/03756-4)

NEMEZIO, KLEINER; YAMAGUCHI, GUILHERME DE CARVALHO; BOITO RAMKRAPES, ANA PAULA; SCHULZ, MARIANE LEICHSENRING; BAPTISTA, IGOR LUCHINI; RIANI, LUIZ AUGUSTO; GONCALVES, LIVIA DE SOUZA; SALE, CRAIG; GENNARI DE MEDEIROS, MARISA HELENA; GUALANO, BRUNO; et al. The role of chronic muscle (in)activity on carnosine homeostasis: a study with spinal cord-injured athletes. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, v. 320, n. 6, p. R824-R832, JUN 2021. (14/11948-8, 19/25032-9, 17/13552-2, 13/07937-8, 15/23176-2, 13/14746-4, 19/12236-5)

PINTO, ANA JESSICA; PECANHA, TIAGO; MEIRELES, KAMILA; BENATTI, FABIANA BRAGA; BONFIGLIOLI, KARINA; DE SA PINTO, ANA LUCIA; LIMA, FERNANDA RODRIGUES; RODRIGUES PEREIRA, ROSA MARIA; COSTA IRIGOYEN, MARIA CLAUDIA; TURNER, JAMES EDWARD; et al. A randomized controlled trial to reduce sedentary time in rheumatoid arthritis: protocol and rationale of the Take a STAND for Health study. Trials, v. 21, n. 1, FEB 12 2020. (15/26937-4, 17/13552-2, 18/19418-9, 16/23319-0)

GOESSLER, KARLA FABIANA; NICOLETTI, CAROLINA FERREIRA; REZENDE, DIEGO AUGUSTO NUNES; SIECZKOWSKA, SOFIA MENDES; ESTEVES, GABRIEL PERRI; GENARIO, RAFAEL; DE OLIVEIRA JUNIOR, GERSIEL NASCIMENTO; MEIRELES, KAMILA; PINTO, ANA JESSICA; NAKAHARA-MELO, MICHELE; et al. Outpatient Screening of Health Status Among Postbariatric Patients during the COVID-19 Pandemic in Sao Paulo, Brazil. OBESITY, v. 28, n. 12, p. 2263-2264, DEC 2020. (15/26937-4, 17/13552-2, 19/18039-7)

GUALANO, BRUNO. Evidence-based physical activity for COVID-19: what do we know and what do we need to know?. BRITISH JOURNAL OF SPORTS MEDICINE, v. N/A, p. 2-pg., 2022-02-15. (17/13552-2)

REZENDE, DIEGO A. N.; PINTO, ANA J.; GOESSLER, KARLA F.; NICOLETTI, CAROLINA F.; SIECZKOWSKA, SOFIA M.; MEIRELES, KAMILA; ESTEVES, GABRIEL P.; GENARIO, RAFAEL; OLIVEIRA JUNIOR, GERSIEL N.; SANTO, MARCO A.; et al. Influence of Adherence to Social Distancing Due to the COVID-19 Pandemic on Physical Activity Level in Post-bariatric Patients. OBESITY SURGERY, v. 31, n. 3, p. 1372-1375, MAR 2021. (19/15231-4, 17/13552-2, 15/26937-4, 19/18039-7)

PECANHA, TIAGO; GOESSLER, KARLA FABIANA; ROSCHEL, HAMILTON; GUALANO, BRUNO. Social isolation during the COVID-19 pandemic can increase physical inactivity and the global burden of cardiovascular disease. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 318, n. 6, p. H1441-H1446, JUN 2020. (17/13552-2, 19/07150-4, 19/18039-7)

NICOLETTI, CAROLINA F.; ROSCHEL, HAMILTON; MEREGE-FILHO, CARLOS; LIMA, ALISSON P.; GIL, SAULO; PINHEL, MARCELA A. S.; NORONHA, NATALIA Y.; SANTO, MARCO A.; JACOME, AMALIA; CRUJEIRAS, ANA B.; et al. Exercise training and DNA methylation profile in post-bariatric women: Results from an exploratory study. FRONTIERS IN SPORTS AND ACTIVE LIVING, v. 5, p. 5-pg., 2023-02-08. (17/13552-2, 16/05638-1, 15/18669-0)

SEKIYA, FELIPE SEITI; DA SILVA, CLARISSE PEREIRA NUNES; OBA-SHINJO, SUELI MIEKO; SANTOS-BEZERRA, DANIELE PEREIRA; RAVAGNANI, FELIPE GUSTAVO; PASQUALUCCI, CARLOS AUGUSTO; GIL, SAULO; GUALANO, BRUNO; BAPTISTA, MAURICIO DA SILVA; CORREA-GIANNELLA, MARIA LUCIA; et al. Identification of two patterns of mitochondrial DNA-copy number variation in postcentral gyrus during aging, influenced by body mass index and type 2 diabetes. Experimental Gerontology, v. 168, p. 8-pg., 2022-08-23. (17/13552-2, 20/02988-7, 20/08091-9, 13/07937-8, 16/15603-0)

MURAI, IGOR H.; FERNANDES, ALAN L.; SALES, LUCAS P.; PINTO, ANA J.; GOESSLER, KARLA F.; DURAN, CAMILA S. C.; SILVA, CARLA B. R.; FRANCO, ANDRE S.; MACEDO, MARINA B.; DALMOLIN, HENRIQUE H. H.; et al. Effect of a Single High Dose of Vitamin D-3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19 A Randomized Clinical Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, v. 325, n. 11, p. 8-pg., 2021-02-17. (20/11102-2, 16/00006-7, 19/24782-4, 15/26937-4, 19/18039-7, 20/05752-4, 17/13552-2)

BRITO, GISELE MENDES; LEITE DO PRADO, DANILO MARCELO; REZENDE, DIEGO AUGUSTO; NAGEM JANOT DE MATOS, LUCIANA DINIZ; LOTURCO, IRINEU; CAMPOS VIEIRA, MARCELO LUIZ; DE SA PINTO, ANA LUCIA; BOUGLEUX ALO, RODRIGO OTAVIO; ARAUJO DE ALBUQUERQUE, LORENA CHRISTINE; BIANCHINI, FLAVIA RIVA; et al. The utility of cardiopulmonary exercise testing in athletes and physically active individuals with or without persistent symptoms after COVID-19. FRONTIERS IN MEDICINE, v. 10, p. 9-pg., 2023-04-26. (17/13552-2, 18/19418-9, 20/04877-8, 15/26937-4)

ESTEVES, GABRIEL P.; SWINTON, PAUL; SALE, CRAIG; GUALANO, BRUNO; ROSCHEL, HAMILTON; DOLAN, EIMEAR. Use of factor analysis to model relationships between bone mass and physical, dietary, and metabolic factors in frail and pre-frail older adults. Journal of Applied Physiology, v. 135, n. 1, p. 8-pg., 2023-07-01. (17/13552-2, 19/05616-6, 20/07860-9, 19/26899-6)

SANTO ANDRE, HELOISA C.; PINTO, ANA JESSICA; MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; ULIAN, MARIANA DIMITROV; GUALANO, BRUNO; BENATTI, FABIANA BRAGA. "Can A Ballerina Eat Ice Cream?": A Mixed-Method Study on Eating Attitudes and Body Image in Female Ballet Dancers. FRONTIERS IN NUTRITION, v. 8, p. 9-pg., 2022-01-06. (17/13552-2, 15/26937-4)

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