Advanced search
Start date

Reducing sedentary time in mild cognitive impairment patients: a randomized controlled trial

Grant number: 19/20814-9
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): January 01, 2020
Effective date (End): December 31, 2020
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Bruno Gualano
Grantee:Isabela Gouveia Marques
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:17/13552-2 - Reducing sedentary time in clinical populations: the take a stand for health study, AP.TEM


This study aims to comprehensively investigate the clinical, physiological, metabolic, and molecular effects of reducing sedentary behavior in specific clinical populations. To that end, we will perform three distinct randomized controlled trials and acute laboratorial studies involving rheumatoid arthritis, bariatric and mild cognitive impairment patients. All of these studies will be under the umbrella title Take a STAND for health, which also gives name to the intervention used in the randomized controlled trials to reduce sedentary behavior. The parallel-group randomized controlled trials aim to investigate the feasibility and efficacy of a newly developed personalized intervention focused on replacing sedentary time with light- (or very light-) intensity physical activity in these populations. A multitude of gold-standard techniques (thoroughly described in the next sections) will be applied to evaluate the effects of the intervention on several outcomes, including sedentary time (primary outcome), physical activity levels, clinical parameters specific to each condition, cardiometabolic risk factors (i.e., insulin sensitivity surrogates, lipid profile, inflammatory biomarkers, immune function, arterial blood pressure, autonomic function, body composition, and aerobic conditioning), and health-related quality of life. In addition, molecular analysis will be performed in both skeletal muscle and blood to gather knowledge on the possible mechanisms related to this intervention. The cross-over acute studies aim to unravel potential mechanisms underlying the effects of breaking up sedentary time with light-intensity physical activity versus carrying out the minimum amount of daily exercise at once and then remaining sedentary versus simply remaining sedentary throughout all sessions, in a well-controlled laboratorial condition. We will assess the physiological and metabolic parameters (i.e., arterial blood pressure, heart rate, insulin sensitivity surrogates, lipid profile, and inflammatory markers) throughout the experimental sessions. In addition, we will explore both skeletal muscle and blood molecular responses elicited by the interventions through targeted analyses of candidate genes and proteins potentially modulated by physical (in) activity as well as untargeted analyses, by means of proteomic and metabolomic approaches. (AU)