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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Muscular Atrophy and Sarcopenia in the Elderly: Is There a Role for Creatine Supplementation?

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Dolan, Eimear [1, 2] ; Artioli, Guilherme G. [1] ; Pereira, Rosa Maria R. [2] ; Gualano, Bruno [1]
Total Authors: 4
[1] Univ Sao Paulo, Fac Med FMUSP, Sch Phys Educ & Sport, Appl Physiol & Nutr Res Grp, Rheumatol Div, BR-01246000 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med FMUSP, Bone Metab Lab, Disciplina Reumatol, BR-01246903 Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: BIOMOLECULES; v. 9, n. 11 NOV 2019.
Web of Science Citations: 0

Sarcopenia is characterized by a loss of muscle mass, quality, and function, and negatively impacts health, functionality, and quality of life for numerous populations, particularly older adults. Creatine is an endogenously produced metabolite, which has the theoretical potential to counteract many of the morphological and metabolic parameters underpinning sarcopenia. This can occur through a range of direct and indirect mechanisms, including temporal and spatial functions that accelerate ATP regeneration during times of high energy demand, direct anabolic and anti-catabolic functions, and enhanced muscle regenerating capacity through positively impacting muscle stem cell availability. Studies conducted in older adults show little benefit of creatine supplementation alone on muscle function or mass. In contrast, creatine supplementation as an adjunct to exercise training seems to augment the muscle adaptive response to the training stimulus, potentially through increasing capacity for higher intensity exercise, and/or by enhancing post-exercise recovery and adaptation. As such, creatine may be an effective dietary strategy to combat age-related muscle atrophy and sarcopenia when used to complement the benefits of exercise training. (AU)

FAPESP's process: 19/05616-6 - The bone response to exercise: a translational research program exploring clinical and mechanistic aspects
Grantee:Eimear Bernadette Dolan
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 17/13552-2 - Reducing sedentary time in clinical populations: the take a stand for health study
Grantee:Bruno Gualano
Support type: Research Projects - Thematic Grants