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Physical activity in patients with Juvenile Takayasu Arteritis: Clinical effects and mechanisms of action.

Grant number: 17/07358-9
Support type:Scholarships in Brazil - Master
Effective date (Start): August 01, 2017
Effective date (End): July 07, 2019
Field of knowledge:Health Sciences - Physical Education
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Bruno Gualano
Grantee:Camilla Astley Amaral Pedroso
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Takayasu's Arteritis (TA) is a chronic inflammatory disease that affects large and medium-sized arteries, predominantly in the aorta and pulmonary arteries, with initial non-specific clinical manifestations such as hypertension, headache, myalgia, arthralgia, fever, weight loss, ischemia and high levels of inflammation. The number of cases describe in children and adolescents has growing, and the hypertension is one of the symptoms most common, followed by other manifestations such as congestive heart failure and intermittent claudication. All clinical manifestations may aggravated by physical inactivity and obesity, beginnings a vicious cycle, whereas the risks of morbidity and mortality increase significantly in the pediatric population, impairing function and physical capacity, quality of life and evolution to adult life. Thereby, physical exercise it is show to be an efficient strategy to reduce all these risk factors, however, no one study, until now, was conducted to available the effects of exercise in children with TA. Objective: Investigated the effects of two 16-week physical exercise programs, one combined exercises (aerobic and muscle strength) and supervised, and another named home-based exercise, where the patients receive a guideline from a physical education professional, teaching how to do the exercise at home. The beneficial effects of the programs expect is to be associated with improved cardiovascular risk factors, function and physical capacity, and body composition. Methods: Two prospective, longitudinal and quasi-experimental studies will conducted in patients with Juvenile Takayasu Arteritis (JTA), where they will perform two exercise programs, being one supervised training (Study 1) or at home (Study 2) over 16 weeks. All patients will be recruited at the Clinical Hospital of the University of São Paulo Medical School (HC-FMUSP), in the Laboratory of Evaluation and Conditioning in Rheumatology, Pediatric Rheumatology outpatient clinics of the Department of Pediatrics, Federal University of São Paulo and The Children's Institute of the University of São Paulo and the Vasculitis Unit of the HC-FMUSP Rheumatology Service. In order to evaluate how a physical exercise program will act on JTA, the following pre and post intervention evaluations will be performed: physical activity level; Global clinical evaluation; Anthropometry and body composition; Hematological and inflammatory blood parameters; Cardiovascular risk factors; Aerobic capacity; Functional capacity and fatigue; quality of life; Endothelial function and magnetic resonance angiography. (AU)

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