Studies on physical (in)activity in patients with rheumatoid arthritis: characterization, associations with disease and effects of breaking up sedentary time

• Grant number: 15/26937-4
• Support type: Scholarships in Brazil - Doctorate (Direct)
• Effective date (Start): July 01, 2016
• Effective date (End): June 30, 2021
• Field of knowledge: Health Sciences - Physical Education
• Principal researcher: Bruno Gualano
• Grantee: Ana Jéssica Pinto
• Home Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 18/19418-9 - Acute and chronic effects of reducing sedentary time in rheumatoid arthritis: the Take a stand for health study, BE.EP.DD

Abstract

Rheumatoid Arthritis (RA) is an autoimmune disease characterized by the involvement of synovial joints, causing pain and swelling. Moreover, clinical manifestations presented by patients with RA may contribute to worsening of physical capacity, quality of life, increasing risk of morbidity and mortality cardiovascular and development of a sedentary lifestyle in these patients. It is known that aerobic exercise programs and strength, performed at moderate to high intensity can improve aerobic capacity, muscle strength, functional capacity, cardiovascular risk factors and body composition in patients with RA. The benefits promoted by physical exercise in patients with RA is undeniable. However, a growing body of evidence suggests that, in addition to compliance with the recommendations of physical activity, individuals should aim to reduce the time spent in sedentary behavior to promote improvements in health. Few studies have shown that breaking up prolonged time spent in sedentary behavior is associated with improvement in cardiovascular risk factors and reduced risk of all-cause mortality. In this regard, it is plausible to assume that interventions aiming to promote reduction of sedentary time and breaking up prolonged sedentary behavior with light physical activity could be beneficial on comorbidities and cardiovascular risk factors in patients with RA. Moreover, to the best of our knowledge, no studies in the literature aimed to determine whether an intervention to promote the reduction of sedentary time and increasing breaking up sedentary behavior is effective in patients with RA. In this context, the aims of this study are: (1) to evaluate the sedentary time, number of breaking up in sedentary time and physical activity level in patients with RA; (2) to investigate the effects of an intervention that promotes breaking up prolonged sedentary time in disease-related parameters, body composition, cardiovascular risk factors, physical function and quality of life in patients with RA. Moreover, to gather knowledge on the mechanisms involved on the breaking up prolonged sedentary behavior in skeletal muscle of these patients. Two studies will be conducted as part of this project. The first is a descriptive cross-sectional study of association (study 1), while the second is a longitudinal, randomized and controlled (study 2). Patients will be recruited at the Rheumatology Unit at the Clinical Hospital of Faculty of Medicine, University of São Paulo (HC-FMUSP). Data collection will be conducted at the Laboratory of Evaluation and Conditioning in Rheumatology. The volunteers will be analyzed for the following parameters: (1) level of (in)physical activity (accelerometry and ActivPAL®); (2) global clinical evaluation (specific questionnaires); (3) anthropometry and body composition (DXA); (4) inflammatory and hematological blood parameters; (5) cardiovascular risk factors (Framingham Survey); (6) aerobic capacity (maximal graded exercise test); (7) functional capacity and fatigue (functional tests and specific questionnaires); (8) quality of life (SF-36); (9) muscle biopsy (study 2). (AU)

Scientific publications

(17)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ASTLEY, CAMILLA; PINTO, ANA JESSICA; BONFA, ELOISA; DA SILVA, CLOVIS ARTUR ALMEIDA; GUALANO, BRUNO. Gaps on rheumatologists' knowledge of physical activity. CLINICAL RHEUMATOLOGY, JAN 2021. Web of Science Citations: 0.

NICOLETTI, CAROLINA FERREIRA; ESTEVES, GABRIEL PERRI; GENARIO, RAFAEL; SANTO, MARCO AURELIO; DE CLEVA, ROBERTO; GUALANO, BRUNO; ROSCHEL, HAMILTON. Nutritional Inadequacies Among Post-bariatric Patients During COVID-19 Quarantine in Sao Paulo, Brazil. OBESITY SURGERY, NOV 2020. Web of Science Citations: 0.

PECANHA, TIAGO; MEIRELES, KAMILA; PINTO, ANA JESSICA; NUNES REZENDE, DIEGO AUGUSTO; IRAHA, AMANDA YURI; MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; KLUSER SALES, ALLAN ROBSON; BONFIGLIOLI, KARINA; DE SA-PINTO, ANA LUCIA; LIMA, FERNANDA RODRIGUES; IRIGOYEN, MARIA CLAUDIA; GUALANO, BRUNO; ROSCHEL, HAMILTON. Increased sympathetic and haemodynamic responses to exercise and muscle metaboreflex activation in post-menopausal women with rheumatoid arthritis. JOURNAL OF PHYSIOLOGY-LONDON, v. 599, n. 3 NOV 2020. Web of Science Citations: 2.

DAMIOT, ANTHONY; PINTO, ANA JESSICA; TURNER, JAMESE.; GUALANO, BRUNO. Immunological Implications of Physical Inactivity among Older Adults during the COVID-19 Pandemic. Gerontology, v. 66, n. 5, p. 431-438, SEP 2020. Web of Science Citations: 3.

SALES, LUCAS PEIXOTO; PINTO, ANA JESSICA; RODRIGUES, SAMARA FERRARI; ALVARENGA, JACKELINE COUTO; GONCALVES, NATALIA; SAMPAIO-BARROS, MARILIA M.; BENATTI, FABIANA BRAGA; GUALANO, BRUNO; RODRIGUES PEREIRA, ROSA MARIA. Creatine Supplementation (3 g/d) and Bone Health in Older Women: A 2-Year, Randomized, Placebo-Controlled Trial. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, v. 75, n. 5, p. 931-938, MAY 2020. Web of Science Citations: 2.

PINTO, ANA JESSICA; DUNSTAN, DAVID W.; OWEN, NEVILLE; BONFA, ELOISA; GUALANO, BRUNO. Combating physical inactivity during the COVID-19 pandemic. Nature Reviews Rheumatology, APR 2020. Web of Science Citations: 0.

PINTO, ANA JESSICA; PECANHA, TIAGO; MEIRELES, KAMILA; BENATTI, FABIANA BRAGA; BONFIGLIOLI, KARINA; DE SA PINTO, ANA LUCIA; LIMA, FERNANDA RODRIGUES; RODRIGUES PEREIRA, ROSA MARIA; COSTA IRIGOYEN, MARIA CLAUDIA; TURNER, JAMES EDWARD; KIRWAN, JOHN P.; OWEN, NEVILLE; DUNSTAN, DAVID W.; ROSCHEL, HAMILTON; GUALANO, BRUNO. A randomized controlled trial to reduce sedentary time in rheumatoid arthritis: protocol and rationale of the Take a STAND for Health study. Trials, v. 21, n. 1 FEB 12 2020. Web of Science Citations: 0.

SMAIRA, FABIANA INFANTE; MAZZOLANI, BRUNA CARUSO; PECANHA, TIAGO; DOS SANTOS, KAMILA MEIRELES; NUNES REZENDE, DIEGO AUGUSTO; ARAUJO, MARIA EUGENIA; BONFIGLIOLI, KARINA; SCAGLIUSI, FERNANDA BAEZA; BENATTI, FABIANA BRAGA; DE SA PINTO, ANA LUCIA; LIMA, FERNANDA RODRIGUES; PEREIRA, ROSA MARIA R.; ROSCHEL, HAMILTON; GUALANO, BRUNO; PINTO, ANA JESSICA. Ultra-processed food consumption associates with higher cardiovascular risk in rheumatoid arthritis. CLINICAL RHEUMATOLOGY, v. 39, n. 5 JAN 2020. Web of Science Citations: 1.

MARIANA DIMITROV ULIAN; PRISCILA DE MORAIS SATO; ANA JÉSSICA PINTO; FABIANA B. BENATTI; PATRICIA LOPES DE CAMPOS-FERRAZ; DESIRE COELHO; ODILON J. ROBLE; FERNANDA SABATINI; ISABEL PEREZ; LUIZ ABURAD; ANDRÉ VESSONI; RAMIRO FERNANDEZ UNSAIN; BRUNO GUALANO; FERNANDA B. SCAGLIUSI. “It is over there, next to that fat lady”: a qualitative study of fat women’s own body perceptions and weight-related discriminations. Saúde e Sociedade, v. 29, n. 4, p. -, 2020.

ATALLA, MARCIO; PINTO, ANA JESSICA; MIELKE, GREGORE IVEN; BENATTI, FABIANA BRAGA; GUALANO, BRUNO. Impact of a Real-World Lifestyle Intervention in an Entire Latin American City with More Than 50,000 People. OBESITY, v. 27, n. 12, p. 1967-1974, DEC 2019. Web of Science Citations: 1.

SAUNDERS, BRYAN; SAITO, TIEMI; KLOSTERHOFF, RAFAEL; DE OLIVEIRA, LUANA FARIAS; BARRETO, GABRIEL; PERIM, PEDRO; PINTO, ANA JESSICA; LIMA, FERNANDA; DE SAPINTO, ANA LUCIA; GUALANO, BRUNO. ``I put it in my head that the supplement would help me{''}: Open-placebo improves exercise performance in female cyclists. PLoS One, v. 14, n. 9 SEP 24 2019. Web of Science Citations: 2.

SABATINI, FERNANDA; ULIAN, MARIANA D.; PEREZ, ISABEL; PINTO, ANA JESSICA; VESSONI, ANDRE; ABURAD, LUIZ; BENATTI, FABIANA B.; DE CAMPOS-FERRAZ, PATRICIA LOPES; COELHO, DESIRE; SATO, PRISCILA DE MORAIS; ROBLE, ODILON J.; UNSAIN, RAMIRO FERNANDEZ; SCHUSTER, ROSEANNE C.; GUALANO, BRUNO; SCAGLIUSI, FERNANDA B. Eating Pleasure in a Sample of Obese Brazilian Women: A Qualitative Report of an Interdisciplinary Intervention Based on the Health at Every Size Approach. JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS, v. 119, n. 9, p. 1470-1482, SEP 2019. Web of Science Citations: 0.

ULIAN, M. D.; ABURAD, L.; DA SILVA OLIVEIRA, M. S.; POPPE, A. C. M.; SABATINI, F.; PEREZ, I.; GUALANO, B.; BENATTI, F. B.; PINTO, A. J.; ROBLE, O. J.; VESSONI, A.; DE MORAIS SATO, P.; UNSAIN, R. F.; BAEZA SCAGLIUSI, F. Effects of health at every size (R) interventions on health-related outcomes of people with overweight and obesity: a systematic review. Obesity Reviews, v. 19, n. 12, p. 1659-1666, DEC 2018. Web of Science Citations: 4.

ATALLA, MARCIO; PINTO, ANA JESSICA; MIELKE, GREGORE IVEN; BACIUK, ERICA PASSOS; BENATTI, FABIANA BRAGA; GUALANO, BRUNO. Tackling Youth Inactivity and Sedentary Behavior in an Entire Latin America City. FRONTIERS IN PEDIATRICS, v. 6, OCT 11 2018. Web of Science Citations: 1.

PECANHA, TIAGO; RODRIGUES, REYNALDO; PINTO, ANA JESSICA; SA-PINTO, ANA LUCIA; GUEDES, LISSIANE; BONFIGLIOLI, KARINA; GUALANO, BRUNO; ROSCHEL, HAMILTON. Chronotropic Incompetence and Reduced Heart Rate Recovery in Rheumatoid Arthritis. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, v. 24, n. 7, p. 375-380, OCT 2018. Web of Science Citations: 0.

ULIAN, MARIANA DIMITROV; PINTO, ANA JESSICA; SATO, PRISCILA DE MORAIS; BENATTI, FABIANA B.; DE CAMPOS-FERRAZ, PATRICIA LOPES; COELHO, DESIRE; ROBLE, ODILON J.; SABATINI, FERNANDA; PEREZ, ISABEL; ABURAD, LUIZ; VESSONI, ANDRE; UNSAIN, RAMIRO FERNANDEZ; ROGERO, MARCELO MACEDO; TOPORCOV, TATIANA NATASHA; DE SA-PINTO, ANA LUCIA; GUALANO, BRUNO; SCAGLIUSI, FERNANDA B. Effects of a new intervention based on the Health at Every Size approach for the management of obesity: The ``Health and Wellness in Obesity{''} study. PLoS One, v. 13, n. 7 JUL 6 2018. Web of Science Citations: 1.

PINTO, ANA JESSICA; ROSCHEL, HAMILTON; DE SA PINTO, ANA LUCIA; LIMA, FERNANDA RODRIGUES; RODRIGUES PEREIRA, ROSA MARIA; SILVA, CLOVIS ARTUR; BONFA, ELOISA; GUALANO, BRUNO. Physical inactivity and sedentary behavior: Overlooked risk factors in autoimmune rheumatic diseases?. AUTOIMMUNITY REVIEWS, v. 16, n. 7, p. 667-674, JUL 2017. Web of Science Citations: 12.