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Aerobic capacity and strength exercise in Takayasu's arteritis: relationships and impacts on clinical, laboratory and vascular end points

Grant number: 18/08735-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): January 01, 2019
Effective date (End): January 31, 2021
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Samuel Katsuyuki Shinjo
Grantee:Alexandre Moura dos Santos
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Takayasu's arteritis (TA) is a primary systemic vasculitis that affects large vessels and their main branches. It mainly affects young women. Blood vessel inflammation may result in stenosis, occlusions, ectasias and/or aneurysms and, consequently, difference of blood pressure between limbs and vascular claudication.Aerobic capacity (CA) is the measure of oxygen uptake, transport and use by the body, characterizing the individual's ability to perform activity. It is also a tool that can predict cardiovascular diseases.Our group was a pioneer in demonstrating that AC is decreased in a small, homogeneous sample of young women with TA disease remission. In addition, the safety and efficacy of aerobic exercises in this sample of patients was shown, as well as the influence of these sessions on the pro-inflammatory and angiogenic serum cytokine behavior. However, due to a small and homogeneous sample, it was not possible to correlate CA with clinical and laboratory parameters and also with the presence, location and extent of vascular damage, which are frequently found in patients with to TA.Moreover, to date, no studies have evaluated safety and impact of a strength exercise session in TA. However, strength exercise session shows health benefits of patients with cardiovascular disease and peripheral arterial disease.Therefore, the objective of the present study is to evaluate in a representative sample of both genders and with the disease in different stages of activity: a) the CA; b) impact and safety of the strength exercise session; c) correlation between AC, as well as strength exercise session, with demographic, clinical, therapeutic, comorbid parameters, and presence, location and degree of vascular damage; d) serum cytokine behavior (pro-inflammatory and angiogenic/anti-angiogenic).

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOS SANTOS, ALEXANDRE MOURA; MISSE, RAFAEL GIOVANI; BORGES, ISABELA BRUNA PIRES; GUALANO, BRUNO; DE SOUZA, ALEXANDRE WAGNER SILVA; TAKAYAMA, LILIAM; PEREIRA, ROSA MARIA R.; SHINJO, SAMUEL KATSUYUKI. Increased modifiable cardiovascular risk factors in patients with Takayasu arteritis: a multicenter cross-sectional study. ADVANCES IN RHEUMATOLOGY, v. 61, n. 1, . (18/08735-3, 19/11367-9, 19/12155-5)
MISSE, R. G.; DOS SANTOS, A. M.; DE SOUZA, J. M.; SHINJO, S. K.. Transcranial direct current stimulation improves myofascial pain syndrome and chronic fatigue. REUMATISMO, v. 72, n. 3, p. 186-188, . (18/08735-3, 19/12155-5)
ARAUJO, C. S. R.; DOS SANTOS, A. M.; OLIVO PALLO, P. A.; PEREIRA, R. M. R.; SHINJO, S. K.. Is there a reliable association between patient-reported limb claudication and vascular imaging methods in Takayasu arteritis?. REUMATISMO, v. 72, n. 2, p. 103-110, . (18/08735-3)
DOS SANTOS, A. M.; MISSE, R. G.; BORGES, I. B. P.; PEREIRA, R. M. R.; SHINJO, S. K.. Is there an association between upper limb claudication and handgrip strength in Takayasu arteritis?. REUMATISMO, v. 72, n. 4, p. 10-pg., . (18/08735-3, 19/12155-5)
DOS SANTOS, ALEXANDRE MOURA; MISSE, RAFAEL GIOVANI; PIRES BORGES, ISABELA BRUNA; SHINJO, SAMUEL KATSUYUKI. The aerobic capacity in patients with antisynthetase syndrome and dermatomyositis. ADVANCES IN RHEUMATOLOGY, v. 60, n. 1, . (17/13109-1, 16/23574-0, 18/08735-3, 16/20371-1)
DOS SANTOS, ALEXANDRE MOURA; MISSE, RAFAEL GIOVANI; PIRES BORGES, ISABELA BRUNA; BUORO PERANDINI, LUIZ AUGUSTO; SHINJO, SAMUEL KATSUYUKI. Physical exercise for the management of systemic autoimmune myopathies: recent findings, and future perspectives. CURRENT OPINION IN RHEUMATOLOGY, v. 33, n. 6, p. 563-569, . (18/08735-3, 19/12155-5, 19/11367-9, 19/11776-6)
MISSE, RAFAEL GIOVANI; BORGES, ISABELA BRUNA PIRES; DOS DANTOS, ALEXANDRE MOURA; GUPTA, LATIKA; SHINJO, SAMUEL KATSUYUKI. Effect of exercise training on fatigue and pain in patients with systemic autoimmune myopathies: A systematic review. AUTOIMMUNITY REVIEWS, v. 20, n. 10, . (19/11367-9, 18/08735-3, 19/12155-5, 19/11776-6)
PIRES BORGES, ISABELA BRUNA; DE OLIVEIRA, DIEGO SALES; MISSE, RAFAEL GIOVANI; DOS SANTOS, ALEXANDRE MOURA; COSTA HONG, VALERIA APARECIDA; BORTOLOTTO, LUIZ APARECIDO; SHINJO, SAMUEL KATSUYUKI. Safety of Atorvastatin in Patients With Stable Systemic Autoimmune Myopathies A Pilot Longitudinal Study. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, v. 27, n. 6, p. S236-S241, . (16/19771-5, 16/23574-0, 18/08735-3, 17/13109-1, 16/20371-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTOS, Alexandre Moura dos. Modifiable cardiovascular risk factors and safety of the combined exercise session in Takayasu\'s arteritis: multicenter, randomized study. 2021. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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