Plasmodium simium: Population Genomics Reveals the Origin of a Reverse Zoonosis

Autor(es):Mostrar menos -

de Oliveira, Thais C. ^[1] ; Rodrigues, Priscila T. ^[1] ; Early, Angela M. ^{[2, 3]} ; Duarte, Ana Maria R. C. ^{[4, 5]} ; Buery, Julyana C. ^[6] ; Bueno, Marina G. ^{[7, 8]} ; Catao-Dias, Jose L. ^[7] ; Cerutti, Crispim ^[6] ; Rona, Luisa D. P. ^{[9, 10]} ; Neafsey, Daniel E. ^{[2, 3]} ; Ferreira, Marcelo U. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo - Brazil

^[2] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA - USA

^[3] Broad Inst MIT & Harvard, Infect Dis & Microbiome Program, Cambridge, MA 02142 - USA

^[4] Univ Sao Paulo, Inst Trop Med Sao Paulo, Lab Protozool, Sao Paulo - Brazil

^[5] State Secretary Hlth, Lab Biochem & Mol Biol, Superintendency Control Endem SUCEN, Sao Paulo - Brazil

^[6] Univ Fed Espirito Santo, Ctr Hlth Sci, Dept Social Med, Vitoria, ES - Brazil

^[7] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Lab Wildlife Comparat Pathol, Sao Paulo - Brazil

^[8] Fiocruz MS, Lab Comparat & Environm Virol, Oswaldo Cruz Inst, Rio De Janeiro - Brazil

^[9] Univ Fed Santa Catarina, Dept Cell Biol Embryol & Genet, Florianopolis, SC - Brazil

^[10] Natl Council Sci & Technol Dev, Natl Inst Sci & Technol Mol Entomol, Rio De Janeiro - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Infectious Diseases; v. 224, n. 11, p. 1950-1961, DEC 1 2021.
• Citações Web of Science: 4

Resumo

Background. The population history of Plasmodium simium, which causes malaria in sylvatic Neotropical monkeys and humans along the Atlantic Coast of Brazil, remains disputed. Genetically diverse P vivax populations from various sources, including the lineages that founded the species P simium, are thought to have arrived in the Americas in separate migratory waves. Methods. We use population genomic approaches to investigate the origin and evolution of P simium. Results. We find a minimal genome-level differentiation between P simium and present-day New World P vivax isolates, consistent with their common geographic origin and subsequent divergence on this continent. The meagre genetic diversity in P simium samples from humans and monkeys implies a recent transfer from humans to non-human primates - a unique example of malaria as a reverse zoonosis of public health significance. Likely genomic signatures of P simium adaptation to new hosts include the deletion of > 40% of a key erythrocyte invasion ligand, PvRBP2a, which may have favored more efficient simian host cell infection. Conclusions. New World P vivax lineages that switched from humans to platyrrhine monkeys founded the P simium population that infects nonhuman primates and feeds sustained human malaria transmission in the outskirts of major cities. (AU)

• Processo FAPESP: 09/51466-4 - Pesquisa da ocorrência de infecção por Leishmania spp. e Plasmodium spp. em primatas neotropicais de vida livre e mantidos em cativeiro no Estado de São Paulo
• Beneficiário: Jose Luiz Catao Dias
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/18740-9 - Bases científicas para a eliminação da malária residual na Amazônia Brasileira
• Beneficiário: Marcelo Urbano Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/10919-4 - Aspectos epidemiológicos da malária humana e símia em áreas de Mata Atlântica no entorno da cidade de São Paulo: estudo da fauna de anofelinos e infecção natural por Plasmodium sp. em Parelheiros e na Serra da Cantareira
• Beneficiário: Ana Maria Ribeiro de Castro Duarte
• Modalidade de apoio: Auxílio à Pesquisa - Regular