ntranasal oxygen reverses hypoxaemia in immobilised free-ranging capybaras (Hydrochoerus hydrochaeris

Autor(es)

Cordeiro, Jefferson F. ^[1] ; Sanches, Mariana C. ^[1] ; Rusch, Elidiane ^[1] ; Xavier, V, Nathalia ; Cassoli, Ana Angelica ^[2] ; Fahlman, Asa ^[3] ; Carregaro, Adriano B. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Anim Sci & Food Engn, Vet Med Dept, Pirassununga, SP - Brazil

^[2] Xavier, Nathalia, V, Univ Sao Paulo, Fac Anim Sci & Food Engn, Vet Med Dept, Pirassununga, SP - Brazil

^[3] Swedish Univ Agr Sci SLU, Swedish Biodivers Ctr, Dept Urban & Rural Dev, Uppsala - Sweden

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 16, n. 11 NOV 30 2021.
• Citações Web of Science: 0

Resumo

Capybara (Hydrochoerus hydrochaeris) is the main host of tick-borne pathogens causing Brazilian spotted fever; therefore, controlling its population is essential, and this may require chemical restraint. We assessed the impact of chemical restraint protocols on the partial pressure of arterial oxygen (PaO2) and other blood variables in 36 capybaras and the effect of different flows of nasal oxygen (O-2) supplementation. The capybaras were hand-injected with dexmedetomidine (5 mu g/kg) and midazolam (0.1 mg/kg) and butorphanol (0.2 mg/kg) (DMB, n = 18) or methadone (0.1 mg/kg) (DMM, n = 18). One-third of the animals were maintained in ambient air throughout the procedure, and one-third were administered intranasal 2 L/min O-2 after 30 min whereas the other third were administered 5 L/min O-2. Arterial blood gases, acid-base status, and electrolytes were assessed 30 and 60 min after drug injection. The DMB and DMM groups did not vary based on any of the evaluated variables. All animals developed hypoxaemia (PaO2 44 {[}30; 73] mmHg, SaO(2) 81 {[}62; 93] %) 30 min before O-2 supplementation. Intranasal O-2 at 2 L/min improved PaO2 (63 {[}49; 97] mmHg and SaO(2) {[}92 {[}85; 98] %), but 9 of 12 capybaras remained hypoxaemic. A higher O-2 flow of 5 L/min was efficient in treating hypoxaemia (PaO2 188 {[}146; 414] mmHg, SaO(2) 100 {[}99; 100] %) in all the 12 animals that received it. Both drug protocols induced hypoxaemia, which could be treated with intranasal oxygen supplementation. (AU)

• Processo FAPESP: 16/21121-9 - Protocolos reversíveis de contenção química em capivaras (Hydrochoerus hydrochaeris) de vida livre
• Beneficiário: Jefferson Farias Cordeiro
• Modalidade de apoio: Bolsas no Brasil - Doutorado