Anti-TNF therapy and immunogenicity in inflammatory bowel diseases: a translational approach

Autor(es)

Genaro, Livia Moreira ^[1] ; Miani Gomes, Luis Eduardo ^[1] ; Menezes de Freitas Franceschini, Ana Paula ^[1] ; Ceccato, Hugo Dugolin ^[1] ; de Jesus, Rafael Nascimento ^[1] ; Lima, Amanda Pereira ^[1] ; Nagasako, Cristiane Kibune ^[2] ; Fagundes, Joao Jose ^[1] ; Setsuko Ayrizono, Maria de Lourdes ^[1] ; Leal, Raquel Franco ^[1]

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Sch Med Sci, Dept Surg, Inflammatory Bowel Dis Res Lab, Colorectal Surg Un, Carlos Chagas St, 420, Cidade Univ Zeferino Vaz, BR-13083878 Campinas, SP - Brazil

^[2] Univ Campinas UNICAMP, Sch Med Sci, Dept Gastroenterol, Campinas - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH; v. 13, n. 12, p. 13916-13930, 2021.
• Citações Web of Science: 0

Resumo

Inflammatory bowel diseases are chronic illnesses that involve intestinal inflammation and are usually diagnosed as Crohn's disease or ulcerative colitis. As these diseases do not have a cure, the goal of treatment is to induce and maintain remission. Monoclonal antibodies have been recognized as the most advanced therapy to avoid complications and reduce the need for surgical approaches. However, although their effectiveness has been proven by several studies, they can trigger the immune system, induce the occurrence of immunogenicity, which may lead to the loss of response and treatment failure. The purpose of this review is to determine what are the main mechanisms involved in IBD; to assess the recommended treatments; to explore the mechanisms of immunogenicity. We also try to explain the detection and describe the existing advances that make possible the clinical application of these approaches. (AU)

• Processo FAPESP: 20/01924-5 - Avaliação dos níveis plasmáticos de Adalimumabe e detecção de anticorpos anti-Adalimumabe em pacientes com Doença de Crohn
• Beneficiário: Livia Moreira Genaro
• Modalidade de apoio: Bolsas no Brasil - Doutorado