Linear and non-linear analyses of autonomic modulation in uncontrolled and controlled elderly resistant hypertensives

Autor(es):Mostrar menos -

Rubio, Tatiane Azevedo ^[1] ; Rodrigues, Bruno ^[2] ; Caieiro da Costa, Larissa Morete ^[1] ; Ferreira-Melo, Silvia Elaine ^[3] ; Bonalume Tacito, Lucia Helena ^{[4, 5]} ; Moreno, Beatriz ^[3] ; Vilela Martin, Jose Fernando ^[1] ; Santo Cestario, Elizabeth do Espirito ^[1] ; Godoy, Moacir Fernandes ^[3] ; Moreno-Junior, Heitor ^[3] ; Yugar-Toledo, Juan Carlos ^[1]

Afiliação do(s) autor(es)

^[1] Med Sch Sao Jose Do Rio Preto FAMERP, Internal Med Dept, Hypertens Clin, Sao Jose Do Rio Preto, SP - Brazil

^[2] Univ Campinas UNICAMP, Sch Phys Educ, Lab Cardiovasc Invest & Exercise, Campinas, SP - Brazil

^[3] Univ Campinas UNICAMP, Sch Med Sci, Cardiovasc Pharmacol & Hypertens Lab, Campinas, SP - Brazil

^[4] Med Sch Sao Jose Do Rio Preto FAMERP, Surg Div, Sao Jose Do Rio Preto, SP - Brazil

^[5] Med Sch Sao Jose Do Rio Preto FAMERP, Clin Div, Sao Jose Do Rio Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Experimental Gerontology; v. 159, MAR 2022.
• Citações Web of Science: 0

Resumo

Resistant hypertension (RHT) is associated with worse outcomes among patients, and sympathetic overactivity is a challenge in treating this clinical condition. Here, we evaluated the autonomic modulation (by linear and non-linear analyses), central blood pressure, and pulse wave velocity in controlled and uncontrolled RHT patients, as well as those in use of beta-blockers. We observed that uncontrolled RHT patients display, in addition to an increase in peripheral blood pressure, presented higher central blood pressure values concerning controlled RHT. Furthermore, despite the use of beta-blockers, both patients in the RHT + beta-blockers and uncontrolled RHT groups had negative changes in autonomic balance as compared with controlled RHT. These results reinforce the importance of autonomic nervous system interventions in managing arterial hypertension. (AU)

• Processo FAPESP: 16/18104-5 - Efeito simpatolítico da estimulação transcraniana por corrente direta (tDCS) sobre a pressão arterial em hipertensos resistentes - Uma nova perspectiva terapêutica
• Beneficiário: Heitor Moreno Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular