Linear and non-linear analyses of autonomic modulation in uncontrolled and controlled elderly resistant hypertensives

Author(s):Show less -

Rubio, Tatiane Azevedo ^[1] ; Rodrigues, Bruno ^[2] ; Caieiro da Costa, Larissa Morete ^[1] ; Ferreira-Melo, Silvia Elaine ^[3] ; Bonalume Tacito, Lucia Helena ^{[4, 5]} ; Moreno, Beatriz ^[3] ; Vilela Martin, Jose Fernando ^[1] ; Santo Cestario, Elizabeth do Espirito ^[1] ; Godoy, Moacir Fernandes ^[3] ; Moreno-Junior, Heitor ^[3] ; Yugar-Toledo, Juan Carlos ^[1]

Affiliation

^[1] Med Sch Sao Jose Do Rio Preto FAMERP, Internal Med Dept, Hypertens Clin, Sao Jose Do Rio Preto, SP - Brazil

^[2] Univ Campinas UNICAMP, Sch Phys Educ, Lab Cardiovasc Invest & Exercise, Campinas, SP - Brazil

^[3] Univ Campinas UNICAMP, Sch Med Sci, Cardiovasc Pharmacol & Hypertens Lab, Campinas, SP - Brazil

^[4] Med Sch Sao Jose Do Rio Preto FAMERP, Surg Div, Sao Jose Do Rio Preto, SP - Brazil

^[5] Med Sch Sao Jose Do Rio Preto FAMERP, Clin Div, Sao Jose Do Rio Preto, SP - Brazil

• Document type: Journal article
• Source: Experimental Gerontology; v. 159, MAR 2022.
• Web of Science Citations: 0

Abstract

Resistant hypertension (RHT) is associated with worse outcomes among patients, and sympathetic overactivity is a challenge in treating this clinical condition. Here, we evaluated the autonomic modulation (by linear and non-linear analyses), central blood pressure, and pulse wave velocity in controlled and uncontrolled RHT patients, as well as those in use of beta-blockers. We observed that uncontrolled RHT patients display, in addition to an increase in peripheral blood pressure, presented higher central blood pressure values concerning controlled RHT. Furthermore, despite the use of beta-blockers, both patients in the RHT + beta-blockers and uncontrolled RHT groups had negative changes in autonomic balance as compared with controlled RHT. These results reinforce the importance of autonomic nervous system interventions in managing arterial hypertension. (AU)

• FAPESP's process: 16/18104-5 - Sympatholytic effects of transcranial direct current stimulation (tDCS) on blood pressure levels in resistant hypertensive subjects - A novel therapeutic approach
• Grantee: Heitor Moreno Junior
• Support Opportunities: Regular Research Grants