ew Strategies for Improving Budesonide Skin Retentio

Autor(es)

Padula, Cristina ^[1] ; Machado, Ian Pompermayer ^[2] ; Vigato, Aryane Alves ^[3] ; de Araujo, Daniele Ribeiro ^[3]

Afiliação do(s) autor(es)

^[1] Univ Parma, Dept Food & Drug, I-43100 Parma - Italy

^[2] Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, BR-01000000 Sao Paulo, SP - Brazil

^[3] Fed Univ ABC, Human & Nat Sci Ctr, Drug & Bioact Delivery Syst Res Grp SISLIBIO, Av. Estados 5001, Bl A, T 3, Lab 503-3, BR-09021058 St Andrew, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PHARMACEUTICS; v. 14, n. 1 JAN 2022.
• Citações Web of Science: 0

Resumo

The aim of this work was to evaluate the ex vivo effect of the combination of two strategies, complexation with cyclodextrin, and poloxamer hydrogels, for improving water solubility in the dermal absorption of budesonide. Two hydrogels containing 20% poloxamer 407, alone or in combination with poloxamer 403, were prepared. Each formulation was loaded with 0.05% budesonide, using either pure budesonide or its inclusion complex with hydroxypropyl-beta-cyclodextrin, and applied in finite dose conditions on porcine skin. The obtained results showed that for all formulations, budesonide accumulated preferentially in the epidermis compared to the dermis. The quantity of budesonide recovered in the receptor compartment was, in all cases, lower than the LOQ of the analytical method, suggesting the absence of possible systemic absorption. The use of a binary poloxamer mixture reduced skin retention, in line with the lower release from the vehicle. When the hydrogels were formulated with the inclusion complex, an increase in budesonide skin retention was observed with both hydrogels. Poloxamer hydrogel proved to be a suitable vehicle for cutaneous administration of budesonide. (AU)

• Processo FAPESP: 19/20303-4 - Organogéis termosensíveis como estratégias para o tratamento de processos inflamatórios: da estrutura supramolecular à avaliação farmacológica
• Beneficiário: Daniele Ribeiro de Araujo
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/14773-8 - Organogéis lecitina-poloxamer como carreadores de fármacos para aplicação tópica: desenvolvimento, perfil de permeação e avaliação estrutural do estrato córneo
• Beneficiário: Aryane Alves Vigato
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto