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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ew Strategies for Improving Budesonide Skin Retentio

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Author(s):
Padula, Cristina [1] ; Machado, Ian Pompermayer [2] ; Vigato, Aryane Alves [3] ; de Araujo, Daniele Ribeiro [3]
Total Authors: 4
Affiliation:
[1] Univ Parma, Dept Food & Drug, I-43100 Parma - Italy
[2] Univ Sao Paulo, Inst Chem, Dept Fundamental Chem, BR-01000000 Sao Paulo, SP - Brazil
[3] Fed Univ ABC, Human & Nat Sci Ctr, Drug & Bioact Delivery Syst Res Grp SISLIBIO, Av. Estados 5001, Bl A, T 3, Lab 503-3, BR-09021058 St Andrew, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PHARMACEUTICS; v. 14, n. 1 JAN 2022.
Web of Science Citations: 0
Abstract

The aim of this work was to evaluate the ex vivo effect of the combination of two strategies, complexation with cyclodextrin, and poloxamer hydrogels, for improving water solubility in the dermal absorption of budesonide. Two hydrogels containing 20% poloxamer 407, alone or in combination with poloxamer 403, were prepared. Each formulation was loaded with 0.05% budesonide, using either pure budesonide or its inclusion complex with hydroxypropyl-beta-cyclodextrin, and applied in finite dose conditions on porcine skin. The obtained results showed that for all formulations, budesonide accumulated preferentially in the epidermis compared to the dermis. The quantity of budesonide recovered in the receptor compartment was, in all cases, lower than the LOQ of the analytical method, suggesting the absence of possible systemic absorption. The use of a binary poloxamer mixture reduced skin retention, in line with the lower release from the vehicle. When the hydrogels were formulated with the inclusion complex, an increase in budesonide skin retention was observed with both hydrogels. Poloxamer hydrogel proved to be a suitable vehicle for cutaneous administration of budesonide. (AU)

FAPESP's process: 19/20303-4 - Thermosensitive organogels as strategies for the treatment of inflammatory processes: from supramolecular structure to pharmacological evaluation
Grantee:Daniele Ribeiro de Araujo
Support Opportunities: Regular Research Grants
FAPESP's process: 19/14773-8 - Organogels lecitin-poloxamer-based for skin delivery: development, ex vivo permeation profile and stratum corneum structural evaluation
Grantee:Aryane Alves Vigato
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)