ognitive functioning throughout adulthood and illness stages in individuals with psychotic disorders and their unaffected sibling

Autor(es):Mostrar menos -

Velthorst, Eva ^{[1, 2, 3]} ; Mollon, Josephine ^[4] ; Murray, Robin M. ^[5] ; de Haan, Lieuwe ^{[2, 6]} ; Germeys, Inez Myin ^[7] ; Glahn, David C. ^[4] ; Arango, Celso ^[8] ; van der Ven, Els ^{[9, 10]} ; Di Forti, Marta ^{[11, 12]} ; Bernardo, Miguel ^[13] ; Guloksuz, Sinan ^{[10, 14]} ; Delespaul, Philippe ^{[10, 15]} ; Mezquida, Gisela ^[13] ; Amoretti, Silvia ^[13] ; Bobes, Julio ^[16] ; Saiz, Pilar A. ^[16] ; Garcia-Portilla, Maria Paz ^[16] ; Santos, Jose Luis ^{[16, 17, 18]} ; Jimenez-Lopez, Estela ^{[19, 16]} ; Sanjuan, Julio ^[20] ; Aguilar, Eduardo J. ^[20] ; Arrojo, Manuel ^[21] ; Carracedo, Angel ^{[22, 23, 24]} ; Lopez, Gonzalo ^[16] ; Gonzalez-Penas, Javier ^[16] ; Parellada, Mara ^[8] ; Atbasoglu, Cem ^[25] ; Saka, Meram Can ^[25] ; Ucok, Alp ^[26] ; Alptekin, Koksal ^{[27, 28]} ; Akdede, Berna ^[27] ; Binbay, Tolga ^[27] ; Altinyazar, Vesile ^[29] ; Ulas, Halis ^[27] ; Yalincetin, Berna ^[28] ; Gumus-Akay, Guvem ^{[30, 31]} ; Beyaz, Burcin Cihan ^[32] ; Soygur, Haldun ^[33] ; Cankurtaran, Eylem Sahin ; Kaymak, Semra Ulusoy ^[34] ; Maric, Nadja P. ^{[35, 36]} ; Mihaljevic, Marina M. ^{[35, 36]} ; Petrovic, Sanja Andric ^{[35, 37]} ; Mirjanic, Tijana ^[38] ; Del-Ben, Cristina Marta ^[39] ; Ferraro, Laura ^[5] ; Gayer-Anderson, Charlotte ^[40] ; Jones, Peter B. ^[41] ; Jongsma, Hannah E. ^{[41, 42]} ; Kirkbride, James B. ^[42] ; La Cascia, Caterina ^[43] ; Lasalvia, Antonio ^[44] ; Tosato, Sarah ^[44] ; Llorca, Pierre-Michel ^[45] ; Menezes, Paulo Rossi ^[46] ; Morgan, Craig ^{[40, 47]} ; Quattrone, Diego ^[12] ; Menchetti, Marco ^[48] ; Selten, Jean-Paul ^{[49, 10]} ; Szoke, Andrei ^[50] ; Tarricone, Ilaria ^[51] ; Tortelli, Andrea ^[52] ; McGuire, Philip ^[5] ; Valmaggia, Lucia ^[53] ; Kempton, Matthew J. ^[5] ; van der Gaag, Mark ^[54] ; Riecher-Rossler, Anita ^[55] ; Bressan, Rodrigo A. ^[56] ; Barrantes-Vidal, Neus ^{[57, 58]} ; Nelson, Barnaby ^{[59, 60]} ; McGorry, Patrick ^{[59, 61, 62]} ; Pantelis, Chris ^{[61, 62]} ; Krebs, Marie-Odile ^[63] ; Ruhrmann, Stephan ^{[64, 65]} ; Sachs, Gabriele ^[66] ; Rutten, Bart P. F. ^[10] ; van Os, Jim ^{[5, 10, 67]} ; Alizadeh, Behrooz Z. ^{[68, 69]} ; van Amelsvoort, Therese ^[10] ; Bartels-Velthuis, Agna A. ^[69] ; Bruggeman, Richard ^{[69, 70]} ; van Beveren, Nico J. ^{[71, 72, 73]} ; Luykx, Jurjen J. ^{[67, 74, 75]} ; Cahn, Wiepke ^{[67, 76]} ; Simons, Claudia J. P. ^{[10, 77]} ; Kahn, Rene S. ^{[1, 78]} ; Schirmbeck, Frederike ^{[2, 6]} ; van Winkel, Ruud ^{[10, 79]} ; Reichenberg, Abraham ^{[1, 3]} ; Study, EU-GEI High Risk

Afiliação do(s) autor(es):Mostrar menos -

^[1] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 - USA

^[2] Amsterdam UMC, Dept Psychiat, Amsterdam - Netherlands

^[3] Icahn Sch Med Mt Sinai, Seaver Ctr Res & Treatment, New York, NY 10029 - USA

^[4] Harvard Med Sch, Dept Psychiat, Boston Childrens Hosp, Boston, MA 02115 - USA

^[5] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London - England

^[6] Arkin Inst Mental Hlth, Amsterdam - Netherlands

^[7] Katholieke Univ Leuven, Dept Neurosci, Psychiat Res Grp, Ctr Contextual Psychiat, Leuven - Belgium

^[8] Univ Complutense, Spanish Mental Hlth Res Network CIBERSAM, Inst Psy, Inst Invest Sanitaria Gregorio Maranon IiSGM, Sch, Dept Child & Adolescent Psychiat, Hosp Gen Univ Gr, Madrid - Spain

^[9] Columbia Univ, Mailman Sch Publ Hlth, New York, NY - USA

^[10] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Med Ctr, Maastricht - Netherlands

^[11] South London & Maudsley NHS Mental Hlth Fdn Trust, London - England

^[12] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Social Genet & Dev Psychiat, London - England

^[13] Univ Barcelona, Barcelona Clin Schizophrenia Unit, Spanish Mental Hlth Res Network CIBERSAM, Hosp Clin Barcelona, IDIBAPS, Neurosci Inst, Barcelona - Spain

^[14] Yale Sch Med, Dept Psychiat, New Haven, CT - USA

^[15] Mondriaan Mental Hlth Care, Heerlen Maastricht - Netherlands

^[16] Univ Oviedo, Mental Hlth Serv Principado Asturias SESPA, Inst Invest Sanitaria Principado Asturias ISPA, Fac Med & Hlth Sci Psychiat, INEUROPA, CIBERSAM, Oviedo - Spain

^[17] Univ Castilla La Mancha, Inst Technol, Neurobiol Res Grp, Cuenca - Spain

^[18] Hosp Virgen Luz, Dept Psychiat, Cuenca - Spain

^[19] Univ Castilla La Mancha, Hlth & Social Res Ctr, Cuenca - Spain

^[20] Univ Valencia, Sch Med, Hosp Clin Univ Valencia, Dept Psychiat, INCLIVA, CIBERSAM, Valencia - Spain

^[21] Complejo Hosp Univ Santiago de Compostela, Inst Invest Sanitaria IDIS, Dept Psychiat, Santiago De Compostela - Spain

^[22] Galician Hlth Serv SERGAS, Inst Invest Sanitaria Santiago de Compostela IDIS, Grp Med Xen, Fdn Publ Galega Med Xen, Santiago De Compostela - Spain

^[23] Univ Santiago de Compostela, Ctr Res Mol Med & Chron Dis CIMUS, Ctr Invest Red Enfermedades Raras CIBERER, Santiago De Compostela - Spain

^[24] Univ Santiago de Compostela, Ctr Res Mol Med & Chron Dis CIMUS, Ctr Nacl Genotipado CEGEN PRB3, Santiago De Compostela - Spain

^[25] Ankara Univ, Sch Med, Dept Psychiat, Ankara - Turkey

^[26] Istanbul Univ, Dept Psychiat, Fac Med, Istanbul - Turkey

^[27] Dokuz Eylul Univ, Sch Med, Dept Psychiat, Izmir - Turkey

^[28] Dokuz Eylul Univ, Hlth Sci Inst, Dept Neurosci, Izmir - Turkey

^[29] Adnan Menderes Univ, Sch Med, Dept Psychiat, Aydin - Turkey

^[30] Ankara Univ, Sch Med, Dept Physiol, Ankara - Turkey

^[31] Ankara Univ, Brain Res Ctr, Ankara - Turkey

^[32] Middle East Tech Univ, Dept Psychol, Ankara - Turkey

^[33] Turkish Federat Schizophrenia Assoc, Ankara - Turkey

^[34] Ankara City Hosp, Psychiat Clin, Ankara - Turkey

^[35] Univ Belgrade, Fac Med, Belgrade - Serbia

^[36] Inst Mental Hlth, Belgrade - Serbia

^[37] Clin Psychiat, Belgrade - Serbia

^[38] Special Hosp Psychiat Disorders Kovin, Kovin - Serbia

^[39] Univ Sao Paulo, Ribeirao Preto Med Sch, Sao Paulo - Brazil

^[40] Kings Coll London, Inst Psychiat, Dept Hlth Serv & Populat Res, London - England

^[41] Univ Cambridge, Dept Psychiat, Cambridge - England

^[42] UCL, Div Psychiat, Psylife Grp, London - England

^[43] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost, Palermo - Italy

^[44] Univ Verona, Sect Psychiat, Dept Neurosci Biomed & Movement, Verona - Italy

^[45] CHU Clermont Ferrand, Clermont Ferrand - France

^[46] Univ Sao Paulo, Dept Prevent Med, Fac Med, Sao Paulo - Brazil

^[47] Kings Coll London, ESRC Ctr Soc & Mental Hlth, London - England

^[48] Univ Bologna, Dept Biomed & NeuroMotor Sci, Bologna - Italy

^[49] Rivierduinen Inst Mental Hlth Care, Leiden - Netherlands

^[50] INSERM, U955, Creteil - France

^[51] Univ Bologna, Dept Med & Surg Sci, Psychiat Unit, Alma Mater Studiorum, Bologna - Italy

^[52] Etab Publ Sante Maison Blanche, Paris - France

^[53] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol, London - England

^[54] Vrije Univ Amsterdam, Amsterdam Publ Mental Hlth Res Inst, Fac Behav & Movement Sci, Dept Clin Psychol, Amsterdam - Netherlands

^[55] Univ Basel, Med Fak, Basel - Switzerland

^[56] Univ Fed Sao Paulo UNIFESP, LiNC Lab Interdisciplinar Neurociencias Clin, Depto Psiquiatria, Escola Paulista Med, Sao Paulo - Brazil

^[57] Univ Autonoma Barcelona, Dept Psicol Clin & Salut, Barcelona - Spain

^[58] Fundacio Sanitaria Sant Pere Claver, Spanish Mental Hlth Res Network CIBERSAM, Barcelona - Spain

^[59] Orygen, Parkville, Vic - Australia

^[60] Univ Melbourne, Ctr Youth Mental Hlth, Parkville, Vic - Australia

^[61] Univ Melbourne, Melbourne Neuropsychiat Ctr, Dept Psychiat, Carlton, Vic - Australia

^[62] Melbourne Hlth, Carlton, Vic - Australia

^[63] Univ Paris, INSERM, GHU Paris, C JAAD, Inst Psychiat, CNRS 3557, U1266, Paris - France

^[64] Univ Cologne, Fac Med, Dept Psychiat & Psychotherapy, Cologne - Germany

^[65] Univ Cologne, Univ Hosp, Cologne - Germany

^[66] Med Univ Vienna, Dept Psychiat & Psychotherapy, Vienna - Austria

^[67] Univ Utrecht, Univ Med Ctr Utrecht, Dept Psychiat, Brain Ctr Rudolf Magnus, Utrecht - Netherlands

^[68] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen - Netherlands

^[69] Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Psychiat, Rob Giel Res Ctr, Groningen - Netherlands

^[70] Univ Groningen, Dept Clin & Dev Neuropsychol, Groningen - Netherlands

^[71] Antes Ctr Mental Hlth Care, Rotterdam - Netherlands

^[72] Erasmus MC, Dept Psychiat, Rotterdam - Netherlands

^[73] Erasmus MC, Dept Neurosci, Rotterdam - Netherlands

^[74] Univ Utrecht, Univ Med Ctr Utrecht, Dept Translat Neurosci, UMC Utrecht Brain Ctr, Utrecht - Netherlands

^[75] GGNet Mental Hlth, Outpatient Opin Clin 2, Apeldoorn - Netherlands

^[76] Altrecht Mental Hlth Care, Altrecht Sci, Utrecht - Netherlands

^[77] GGzE Inst Mental Hlth Care, Eindhoven - Netherlands

^[78] Educ & Clin Ctr MIRECC, James J Peters Dept Vet Affairs, VISN 2 Mental Illness Res, Med Ctr, New York, NY - USA

^[79] Katholieke Univ Leuven, Dept Neurosci, Psychiat Res Grp, Ctr Clin Psychiat, Leuven - Belgium

• Tipo de documento: Artigo Científico
• Fonte: MOLECULAR PSYCHIATRY; v. 26, n. 8, p. 4529-4543, AUG 2021.
• Citações Web of Science: 3

Resumo

Important questions remain about the profile of cognitive impairment in psychotic disorders across adulthood and illness stages. The age-associated profile of familial impairments also remains unclear, as well as the effect of factors, such as symptoms, functioning, and medication. Using cross-sectional data from the EU-GEI and GROUP studies, comprising 8455 participants aged 18 to 65, we examined cognitive functioning across adulthood in patients with psychotic disorders (n = 2883), and their unaffected siblings (n = 2271), compared to controls (n = 3301). An abbreviated WAIS-III measured verbal knowledge, working memory, visuospatial processing, processing speed, and IQ. Patients showed medium to large deficits across all functions (ES range = -0.45 to -0.73, p < 0.001), while siblings showed small deficits on IQ, verbal knowledge, and working memory (ES = -0.14 to -0.33, p < 0.001). Magnitude of impairment was not associated with participant age, such that the size of impairment in older and younger patients did not significantly differ. However, first-episode patients performed worse than prodromal patients (ES range = -0.88 to -0.60, p < 0.001). Adjusting for cannabis use, symptom severity, and global functioning attenuated impairments in siblings, while deficits in patients remained statistically significant, albeit reduced by half (ES range = -0.13 to -0.38, p < 0.01). Antipsychotic medication also accounted for around half of the impairment in patients (ES range = -0.21 to -0.43, p < 0.01). Deficits in verbal knowledge, and working memory may specifically index familial, i.e., shared genetic and/or shared environmental, liability for psychotic disorders. Nevertheless, potentially modifiable illness-related factors account for a significant portion of the cognitive impairment in psychotic disorders. (AU)

• Processo FAPESP: 12/05178-0 - Esquizofrenia e outros transtornos psicóticos: determinantes sociais e biológicos
• Beneficiário: Paulo Rossi Menezes
• Modalidade de apoio: Auxílio à Pesquisa - Temático